Effects of the 5-HT3 antagonist ondansetron on benzodiazepine-induced operant behavioural dependence in rats

Self Administration of and Behavioral Dependence on Drugs

1969 • 489 citations

The psychopharmacology of 5-HT3 receptors

1990 • 246 citations

Homeostatic theory of drug tolerance: A general model of physiological adaptation.

1991 • 214 citations

Nucleus accumbens as a substrate for the aversive stimulus effects of opiate withdrawal

1989 • 145 citations

Animal models of drug withdrawal symptoms

1990 • 139 citations

Is the motivational effect of opiate withdrawal reflected by common somatic indices of precipitated withdrawal? A place conditioning study in the rat

1987 • 108 citations

Ondansetron inhibits a behavioural consequence of withdrawing from drugs of abuse

1990 • 108 citations

Parallel processing strategies in the application of microcomputers to the behavioral laboratory

1985 • 107 citations

Dependence on tetrahydrocannabinol in rhesus monkeys.

1986 • 106 citations

Sites of action of ondansetron to inhibit withdrawal from drugs of abuse

1990 • 96 citations

Clonidine antagonizes naloxone-induced suppression of conditioned behavior and body weight loss in morphine-dependent rats

1978 • 74 citations

Cocaine withdrawal produces behavioral disruptions in rats

1987 • 67 citations

Operant behavior in the morphine-dependent rhesus monkey.

1973 • 63 citations

The effects of ondansetron (GR38032F) in rats and mice treated subchronically with diazepam

1989 • 59 citations

Tolerance and dependence after continuous morphine infusion from osmotic pumps measured by operant responding in rats

1990 • 54 citations

Psychoactive drugs: Tolerance and sensitization

1990 • 53 citations

Effects of the 5-HT3 antagonist GR38032F (ondansetron) on benzodiazepine withdrawal in rats

1990 • 51 citations

Effects of 5-HT3 receptor antagonists on behavioural measures of naloxone-precipitated opioid withdrawal

1991 • 50 citations

Preclinical anxiolytic versus antipsychotic profiles of the 5‐HT₃ antagonists ondansetron, zacopride, 3α‐tropanyl‐1H‐indole‐3‐carboxylic acid ester, and 1αH, 3α, 5αH‐tropan‐3‐yl‐3,5‐dichlorobenzoate

1991 • 44 citations

A microcomputer system for the control of behavioral experiments

1981 • 41 citations

Nicotine dependence in rats

1989 • 37 citations

Behavioral dependence produced by continuous phencyclidine infusion in rhesus monkeys.

1984 • 36 citations

Evaluation of the dependence potential of the selective 5-H1A agonist ipsapirone in rats and of its effects on benzodiazepine withdrawal

1991 • 30 citations

Phencyclidine dependence: the relationship of dose and serum concentrations to operant behavioral effects.

1991 • 30 citations

Evidence that the increased anxiety detected in the elevated plus-maze during chlordiazepoxide withdrawal is not due to enhanced noradrenergic activity

1989 • 23 citations

Effects of food FR and food deprivation on disruptions in food-maintained performance of monkeys during phencyclidine withdrawal

1991 • 22 citations

Behavioral stimulation induced by ethanol withdrawal

1974 • 21 citations

The 5-HT3 receptor antagonists ICS 205-930 and GR38032F, putative anxiolytic drugs, differ from diazepam in their pharmacological profile

1989 • 20 citations

Behavioral effects of benzodiazepine antagonists in chlordiazepoxide tolerant and non-tolerant rats

1989 • 17 citations

Disruption of schedule-controlled behavior by Ro 15-1788 one day after acute treatment with benzodiazepines

1986 • 16 citations

Effects of the 5HT1A agonist anxiolytic gepirone on benzodiazepine withdrawal signs in rats1

1991 • 14 citations

Effects of the 5-HT3 antagonist ICS 205-930 on benzodiazepine withdrawal signs in rats1

1992 • 14 citations

Effects of cocaine administration and withdrawal on the performance of pigeons under a fixed-consecutive-number schedule with and without an external discriminative stimulus

1990 • 9 citations

Increased sensitivity to benzodiazepine antagonists in rats following chronic treatment with a low dose of diazepam

1990 • 9 citations

Evaluation of Anxiolytic Action of Ondansetron in Rats during Withdrawal from Chronic Chlordiazepoxide

1992 • 7 citations