The Role of mRNA Stability in the Control of Globin Gene Expression

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

AU-rich elements: characterization and importance in mRNA degradation

1995 • 1,936 citations

Conserved Structures and Diversity of Functions of RNA-Binding Proteins

1994 • 1,873 citations

S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control

1996 • 1,604 citations

Regulating the fate of mRNA: The control of cellular iron metabolism

1993 • 1,233 citations

Messenger RNA degradation in eukaryotes

1993 • 858 citations

FMR1 Protein: Conserved RNP Family Domains and Selective RNA Binding

1993 • 721 citations

A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.

1993 • 660 citations

INTERRELATIONSHIPS OF THE PATHWAYS OF mRNA DECAY AND TRANSLATION IN EUKARYOTIC CELLS

1996 • 653 citations

Degradation of mRNA in eukaryotes

1995 • 648 citations

The "beta-like-globin" gene domain in human erythroid cells.

1985 • 634 citations

The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein

1993 • 632 citations

The transcriptional control of hematopoiesis [see comments]

1996 • 608 citations

Identification of the Iron-Responsive Element for the Translational Regulation of Human Ferritin mRNA

1987 • 547 citations

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

1991 • 546 citations

Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript.

1994 • 511 citations

The nucleotide sequence of the human β-globin gene

1980 • 502 citations

Ribosome pausing and stacking during translation of a eukaryotic mRNA.

1988 • 468 citations

Premature translational termination triggers mRNA decapping

1994 • 399 citations

A developmentally stable chromatin structure in the human beta-globin gene cluster.

1986 • 391 citations

Sequence-specific RNA binding by the HIV-1 Rev protein

1989 • 384 citations

A major positive regulatory region located far upstream of the human alpha-globin gene locus.

1990 • 337 citations

Haemoglobin Constant Spring—A Chain Termination Mutant ?

1971 • 305 citations

Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3′ UTR and does not involve poly(A) tail shortening.

1994 • 290 citations

Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein.

1992 • 281 citations

REGULATED mRNA STABILITY

1990 • 279 citations

Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3′ untranslated region.

1994 • 267 citations

Identification of two KH domain proteins in the alpha-globin mRNP stability complex.

1995 • 244 citations

Nuclear scaffold attachment sites in the human globin gene complexes.

1988 • 225 citations

The Mechanisms of mRNA Degradation in Eukaryotes

1999 • 204 citations

A regulated RNA binding protein also possesses aconitase activity.

1991 • 204 citations

Detection and Characterization of a 3′ Untranslated Region Ribonucleoprotein Complex Associated with Human α-Globin mRNA Stability

1995 • 194 citations

Human fetal to adult hemoglobin switching: changes in chromatin structure of the beta-globin gene locus.

1983 • 190 citations

Secondary Structure is the Major Determinant for Interaction of HIV rev Protein with RNA

1990 • 188 citations

Determinants that contribute to cytoplasmic stability of human c-fos and beta-globin mRNAs are located at several sites in each mRNA.

1988 • 178 citations

Characterization of the Major Regulatory Element Upstream of the Human a-Globin Gene Cluster

1991 • 175 citations

Erythroid Cell-Specific mRNA Stability Elements in the α2-Globin 39 Nontranslated Region

1995 • 167 citations

Biosynthesis and stability of globin mRNA in cultured erythroleukemic friend cells

1976 • 163 citations

Expression of EVI1 in myelodysplastic syndromes and other hematologic malignancies without 3q26 translocations

1994 • 153 citations

Synthesis and degradation of type I procollagen mRNAs in cultured human skin fibroblasts and the effect of cortisol.

1985 • 148 citations

Complete nucleotide sequence of the human δ-globin gene

1980 • 146 citations

Erythroid cell-specific determinants of alpha-globin mRNA stability.

1994 • 145 citations

The iron-responsive element binding protein: a method for the affinity purification of a regulatory RNA-binding protein.

1989 • 144 citations

Differentiation of the mRNA transcripts originating from the alpha 1- and alpha 2-globin loci in normals and alpha-thalassemics.

1981 • 141 citations

HÆMOGLOBIN-H DISEASE DUE TO A UNIQUE HÆMOGLOBIN VARIANT WITH AN ELONGATED α-CHAIN

1971 • 141 citations

Regulation of messenger RNA stability in mouse erythroleukemia cells

1985 • 138 citations

Cloning and complete nucleotide sequence of human 5'-alpha-globin gene.

1980 • 136 citations

Repeating structure of cytoplasmic poly(A)-ribonucleoprotein.

1980 • 134 citations

Half-lives of beta and gamma globin messenger RNAs and of protein synthetic capacity in cultured human reticulocytes

1985 • 108 citations

Stability of globin mRNA in terminally differentiating murine erythroleukemia cells

1981 • 108 citations

Haemoglobin Icaria, a new chain-termination mutant which causes α thalassaemia

1974 • 104 citations

HÆMOGLOBIN TAK: A VARIANT WITH ADDITIONAL RESIDUES AT THE END OF THE β-CHAINS

1971 • 103 citations

Messenger RNA turnover in cell-free extracts

1990 • 101 citations

Peptide Chain Synthesis of Human Hemoglobins A and A2

1966 • 96 citations

The interaction of α thalassaemia with heterozygous β thalassaemia

1982 • 96 citations

Dissecting RNA-protein interactions: RNA-RNA recognition by Rop

1995 • 92 citations

Hemoglobin messenger ribonucleic acid. Synthesis of 9 S and ribosomal ribonucleic acid during erythroid cell development

1969 • 89 citations

Genetic interactions in thalassemia intermedia: Analysis of β‐Mutations, α‐Genotype, γ‐Promoters, and β‐LCR hypersensitive sites 2 and 4 in Italian patients

1995 • 87 citations

Hemoglobin Koya Dora: high frequency of a chain termination mutant.

1975 • 87 citations

Nuclease activity associated with mammalian mRNA in its native state: possible basis for selectivity in mRNA decay.

1990 • 81 citations

A change in the stability of globin mRNA during the induction of murine erythroleukemia cells

1978 • 79 citations

Haemoglobin Constant Spring has an unstable α chain messenger RNA

1982 • 79 citations

Human beta and delta globin messenger RNAs turn over at different rates

1983 • 72 citations

Hemoglobin Cranston, an unstable variant having an elongated beta chain due to nonhomologous crossover between two normal beta chain genes.

1975 • 71 citations

The stability of human beta-globin mRNA is dependent on structural determinants positioned within its 3' untranslated region

1996 • 68 citations

Analysis of the human alpha-globin gene cluster in transgenic mice.

1993 • 65 citations

Developmental Silencing of the Embryonic ζ-Globin Gene: Concerted Action of the Promoter and the 3′-Flanking Region Combined with Stage-Specific Silencing by the Transcribed Segment

1996 • 63 citations

Terminal differentiation of murine erythroleukemia cells: physical stabilization of end- stage cells

1982 • 55 citations

Negative Regulation of Globin Gene Expression during Megakaryocytic Differentiation of a Human Erythroleukemic Cell Line

1991 • 54 citations

45,X/46,XYq dic-Geschlechtschromosomenmosaik

1975 • 54 citations

REGULATION OF mRNA STABILITY IN DEVELOPMENT

1994 • 54 citations

Suppression of human alpha-globin gene expression mediated by the recombinant adeno-associated virus 2-based antisense vectors.

1994 • 53 citations

Chromatin Structure and Developmental Expression of the Human α-Globin Cluster

1986 • 50 citations

Analysis of a 70 kb segment of DNA containing the human ζ and α-globin genes linked to their regulatory element (HS-40) in transgenic mice

1994 • 45 citations

Configuration of β-globin messenger RNA in rabbit reticulocytes

1984 • 43 citations

Erythroleukemia cells: variants inducible for hemoglobin synthesis without commitment to terminal cell division.

1983 • 41 citations

Molecular Evolution Above the Species Level: Branching Pattern, Rates, and Mechanisms

1982 • 40 citations

Haemoglobin Constant Spring Synthesis in Red Cell Precursors

1974 • 38 citations

Theoretical analysis of a model for globin messenger RNA accumulation during erythropoiesis

1977 • 35 citations

The erythropoietic mouse spleen—A model system of development

1976 • 33 citations

Human alpha-globin genes demonstrate autonomous developmental regulation in transgenic mice.

1991 • 33 citations

Complementary change in cis determinants and trans factors in the evolution of an mRNP stability complex.

1996 • 32 citations

Hemoglobin Saverne: A New Variant with Elongated β Chains: Structural and Functional Properties

1988 • 27 citations

Developmental regulation of the human zeta globin gene in transgenic mice

1990 • 25 citations

The Development of Haemoglobin A₂ in Normal Negro Infants and in Sickle Cell Disease

1978 • 23 citations

Effect of the 3′-untranslated region on the expression levels and rnRNA stability of α1(I) collagen gene

1995 • 22 citations

Analysis of the human zeta-globin gene promoter in transgenic mice

1993 • 22 citations

Messenger RNA stabilization in chicken lens development: A reexamination

1991 • 19 citations

Analysis of the human zeta-globin gene promoter in transgenic mice

1993 • 17 citations

Half-life and rate of synthesis of globin messenger ribonucleic acid. Determination of half-life of messenger ribonucleic acid and its relative synthetic rate in erythroid cells

1974 • 16 citations

The Initiation of Globin Synthesis in Differentiating Rabbit‐Bone‐Marrow Erythroid Cells

1976 • 16 citations

New tech in biotech

1989 • 8 citations

Thalassemia intermedia: compound heterozygous β∘/β+-thalassemia and co-inherited heterozygous α+-thalassemia

1993 • 7 citations

Decay of globin mRNA during megakaryocytic differentiation of erythroleukemic cell line is accomplished through shortening of the poly(A) tail and degradation from the 3′ end of the transcript

1995 • 5 citations