Human alpha-globin genes demonstrate autonomous developmental regulation in transgenic mice.

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs.

1985 • 1,052 citations

Hemoglobin: Molecular, Genetic and Clinical Aspects.

1986 • 1,005 citations

The Molecular Basis of Blood Diseases.

1987 • 648 citations

The "beta-like-globin" gene domain in human erythroid cells.

1985 • 634 citations

A review of the molecular genetics of the human alpha-globin gene cluster

1989 • 443 citations

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice

1990 • 364 citations

A dominant control region from the human β-globin locus conferring integration site-independent gene expression

1989 • 346 citations

The molecular basis of blood diseases

1988 • 341 citations

The evolution and sequence comparison of two recently diverged mouse chromosomal β-globin genes

1979 • 337 citations

A major positive regulatory region located far upstream of the human alpha-globin gene locus.

1990 • 337 citations

Developmental regulation of β-globin gene switching

1988 • 328 citations

The β-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner

1989 • 302 citations

Human gamma- to beta-globin gene switching in transgenic mice.

1990 • 291 citations

Localization of the human α-globin structural gene to chromosome 16 in somatic cell hybrids by molecular hybridization assay

1977 • 282 citations

A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.

1989 • 269 citations

Gamma delta beta-thalassemia due to a de novo mutation deleting the 5' beta-globin gene activation-region hypersensitive sites.

1989 • 240 citations

Haemoglobin switching in human embryos: asynchrony of ζ → α and ε → γ-globin switches in primitive and definitive erythropoietic lineage

1985 • 218 citations

Homology and concerted evolution at the α1 and α2 loci of human α-globin

1981 • 207 citations

An embryonic pattern of expression of a human fetal globin gene in transgenic mice

1986 • 204 citations

Two 3' sequences direct adult erythroid-specific expression of human beta-globin genes in transgenic mice.

1987 • 202 citations

Chromosomal localization of human β globin gene on human chromosome 11 in somatic cell hybrids

1978 • 189 citations

Precise localization of human beta-globin gene complex on chromosome 11.

1979 • 175 citations

Autonomous Developmental Control of Human Embryonic Globin Gene Switching in Transgenic Mice

1990 • 151 citations

Human alpha-globin gene expression. The dominant role of the alpha 2-locus in mRNA and protein synthesis.

1986 • 142 citations

Versatile cosmid vectors for the isolation, expression, and rescue of gene sequences: studies with the human alpha-globin gene cluster.

1983 • 137 citations

Human Sickle Hemoglobin in Transgenic Mice

1990 • 131 citations

Synthesis of Functional Human Hemoglobin in Transgenic Mice

1989 • 125 citations

The human beta-globin locus activation region alters the developmental fate of a human fetal globin gene in transgenic mice.

1989 • 112 citations

A transgenic mouse model of sickle cell disorder

1990 • 105 citations

High-level erythroid expression of human alpha-globin genes in transgenic mice.

1989 • 96 citations

High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human hemoglobin in murine erythrocytes.

1989 • 83 citations

Hemoglobin a Synthesis in the Developing Fetus

1973 • 77 citations

Theta, zeta, and epsilon globin messenger RNAs are expressed in adults

1989 • 58 citations

Globin gene expression in erythroid human fetal liver cells.

1989 • 57 citations

The G gamma:A gamma composition of fetal hemoglobin in fetuses and newborns

1979 • 45 citations

Characterization, Expression, and Evolution of the Mouse Embryonic ζ-Globin Gene

1985 • 43 citations

Human embryonic zeta-globin chains in fetal and newborn blood

1989 • 39 citations

High resolution gene mapping of the human alpha globin locus.

1987 • 39 citations

Human embryonic zeta-globin chains in fetal and newborn blood

1989 • 33 citations

DNase I super-hypersensitive sites direct high level erythroid expression of human alpha-, beta- and beta s- globin genes in transgenic mice.

1989 • 32 citations

Hemoglobin I Mutation Encoded at Both α-Globin Loci on the Same Chromosome: Concerted Evolution in the Human Genome

1984 • 32 citations

The G gamma:A gamma composition of fetal hemoglobin in fetuses and newborns

1979 • 31 citations

Developmental regulation of the human zeta globin gene in transgenic mice

1990 • 25 citations

Beta-globin enhancers target expression of a heterologous gene to erythroid tissues of transgenic mice.

1989 • 24 citations

Developmental regulation of globin gene expression

1992 • 23 citations

Polymorphism and Gene Conversion in Mouse α-Globin Haplotypes

1987 • 22 citations

Ratios of α-to β-globin mRNA and regulation of globin synthesis in reticulocytes

1977 • 22 citations

The Value of the Refraction Goniometer in Chemical Work 1

1886 • 12 citations

The Gγ: Aγ composition of fetal hemoglobin in fetuses and newborns

1979 • 11 citations

A transgenic mouse model of sickle cell disorder

1990 • 6 citations

Theta, zeta, and epsilon globin messenger RNAs are expressed in adults

1989 • 5 citations