Analysis of the human alpha-globin gene cluster in transgenic mice.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

Identification of two distinct regulatory regions adjacent to the human β-interferon gene

1983 • 1,076 citations

The chromosomal arrangement of human α-like globin genes: Sequence homology and α-globin gene deletions

1980 • 531 citations

A review of the molecular genetics of the human alpha-globin gene cluster

1989 • 443 citations

Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids

1987 • 440 citations

A dominant control region from the human β-globin locus conferring integration site-independent gene expression

1989 • 346 citations

Recombination at the human α-globin gene cluster: Sequence features and topological constraints

1987 • 345 citations

A major positive regulatory region located far upstream of the human alpha-globin gene locus.

1990 • 337 citations

Detailed analysis of the site 3 region of the human beta-globin dominant control region.

1990 • 320 citations

A truncated human chromosome 16 associated with α thalassaemia is stabilized by addition of telomeric repeat (TTAGGG)n

1990 • 288 citations

An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes.

1989 • 280 citations

β-Globin gene inactivation by DNA translocation in γβ-thalassaemi

1983 • 266 citations

Rapid reprogramming of globin gene expression in transient heterokaryons

1986 • 246 citations

Gamma delta beta-thalassemia due to a de novo mutation deleting the 5' beta-globin gene activation-region hypersensitive sites.

1989 • 240 citations

The 5′HS2 of the globin locus control region enhances transcription through the interaction of a multimeric complex binding at two functionally distinct NF-E2 binding sites.

1991 • 231 citations

Molecular analysis of the human beta-globin locus activation region.

1989 • 218 citations

Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice.

1992 • 218 citations

DNasel hypersensitive sites 1, 2 and 3 of the human β-globin dominant control region direct position-independent expression

1990 • 186 citations

Characterization of the Major Regulatory Element Upstream of the Human a-Globin Gene Cluster

1991 • 175 citations

A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin

1992 • 147 citations

Alpha-thalassemia caused by a large (62 kb) deletion upstream of the human alpha globin gene cluster

1990 • 112 citations

In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction.

1992 • 95 citations

δβ Thalassemia and Hereditary Persistence of Fetal Hemoglobin

1991 • 74 citations

Analysis of the human alpha globin upstream regulatory element (HS-40) in transgenic mice.

1992 • 73 citations

Inactivation of human alpha-globin gene expression by a de novo deletion located upstream of the alpha-globin gene cluster.

1990 • 61 citations

A single beta-globin locus control region element (5' hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice.

1992 • 57 citations

In situ hybridization reveals co-expression of embryonic and adult α globin genes in the earliest murine erythrocyte progenitors

1992 • 53 citations

DNA Sequences Regulating Human Globin Gene Transcription in Nondeletional Hereditary Persistence of Fetal Hemoglobin

1989 • 48 citations

Alpha-thalassemia resulting from deletion of regulatory sequences far upstream of the alpha-globin structural genes

1991 • 41 citations

The developmental regulation of the human ζ-globin gene in transgenic mice employing β-galactosidase as a reporter gene

1992 • 33 citations

Human alpha-globin genes demonstrate autonomous developmental regulation in transgenic mice.

1991 • 33 citations

Role of upstream DNase I hypersensitive sites in the regulation of human alpha globin gene expression

1993 • 31 citations

In Vivo Footprinting of the Human α-Globin Locus Upstream Regulatory Element by Guanine and Adenine Ligation-Mediated Polymerase Chain Reaction

1992 • 26 citations

Developmental regulation of the human zeta globin gene in transgenic mice

1990 • 25 citations

Regulation of human embryonic globin genes zeta 2 and epsilon in stably transformed mouse erythroleukemia cells

1992 • 16 citations

Human α-Globin Genes Demonstrate Autonomous Developmental Regulation in Transgenic Mice

1991 • 14 citations