The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

1991 • 3,422 citations

Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox

1991 • 2,062 citations

hnRNP PROTEINS AND THE BIOGENESIS OF mRNA

1993 • 1,486 citations

Instability of a 550-Base Pair DNA Segment and Abnormal Methylation in Fragile X Syndrome

1991 • 1,482 citations

Absence of expression of the FMR-1 gene in fragile X syndrome

1991 • 1,456 citations

Vectors for selective expression of cloned DNAs by T7 RNA polymerase

1987 • 1,449 citations

New metal chelate adsorbent selective for proteins and peptides containing neighbouring histidine residues

1987 • 1,107 citations

Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of Yeast

1986 • 946 citations

Mapping of DNA Instability at the Fragile X to a Trinucleotide Repeat Sequence P(CCG) n

1991 • 903 citations

The structure of an antigenic determinant in a protein

1984 • 841 citations

Fragile X Genotype Characterized by an Unstable Region of DNA

1991 • 794 citations

RNA-binding proteins as developmental regulators.

1989 • 679 citations

Direct Diagnosis by DNA Analysis of the Fragile X Syndrome of Mental Retardation

1991 • 637 citations

Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.

1992 • 619 citations

A point mutation in the FMR-1 gene associated with fragile X mental retardation

1993 • 619 citations

The pre-mRNA binding K protein contains a novel evolutionary conserved motif

1993 • 526 citations

A specific transcription factor that can bind either the 5S RNA gene or 5S RNA.

1980 • 511 citations

Triplet repeat mutations in human disease

1992 • 417 citations

Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins.

1988 • 399 citations

U3, U8 and U13 comprise a new class of mammalian snRNPs localized in the cell nucleolus.

1989 • 391 citations

Physical mapping across the fragile X: Hypermethylation and clinical expression of the fragile X syndrome

1991 • 357 citations

Classification and purification of proteins of heterogeneous nuclear ribonucleoprotein particles by RNA-binding specificities.

1988 • 327 citations

Fragile sites on human chromosomes

1985 • 316 citations

The elav Gene Product of Drosophila , Required in Neurons, Has Three RNP Consensus Motifs

1988 • 302 citations

Purification and partial characterization of a nucleolar scleroderma antigen (Mr = 34,000; pI, 8.5) rich in NG,NG-dimethylarginine.

1985 • 282 citations

Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein.

1992 • 281 citations

Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62

1992 • 271 citations

Fragile Sites on Human Chromosomes

1986 • 242 citations

Chelating peptide-immobilized metal ion affinity chromatography. A new concept in affinity chromatography for recombinant proteins.

1988 • 237 citations

Association of a 5S gene transcription factor with 5S RNA and altered levels of the factor during cell differentiation

1980 • 233 citations

Primary structure of human nuclear ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA, and pre-rRNA-binding proteins.

1987 • 229 citations

Fragile X syndrome without CCG amplification has an FMR1 deletion

1992 • 219 citations

Abnormal pattern detected in fragile-X patients by pulsed-field gel electrophoresis

1991 • 213 citations

Sequence analysis of cytoplasmic mRNA-binding proteins of Xenopus oocytes identifies a family of RNA-binding proteins.

1992 • 204 citations

Meiosis-specific RNA splicing in yeast

1991 • 191 citations

Isolation of the heterogeneous nuclear RNA-ribonucleoprotein complex (hnRNP): a unique supramolecular assembly.

1984 • 177 citations

Isolation of Sequences that Span the Fragile X and Identification of a Fragile X-Related CpG Island

1991 • 174 citations

A microdeletion of less than 250 kb, including the proximal part of the FMR-I gene and the fragile-X site, in a male with the clinical phenotype of fragile-X syndrome.

1992 • 173 citations

Mammalian heterogeneous nuclear ribonucleoprotein complex protein A1. Large-scale overproduction in Escherichia coli and cooperative binding to single-stranded nucleic acids.

1988 • 170 citations

cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera.

1991 • 167 citations

Nucleotide sequence of the pnp gene of Escherichia coli encoding polynucleotide phosphorylase. Homology of the primary structure of the protein with the RNA-binding domain of ribosomal protein S1.

1987 • 135 citations

MER1, a Yeast Gene Required for Chromosome Pairing and Genetic Recombination, Is Induced in Meiosis

1990 • 124 citations

Ribonucleoprotein particles in cellular processes.

1988 • 123 citations

Mammalian single-stranded DNA binding protein UP I is derived from the hnRNP core protein A1.

1986 • 107 citations

cDNA cloning of human hnRNP protein Al reveals the existence of multiple mRNA isoforms

1988 • 107 citations

Fragile X Syndrome: A Unique Mutation in Man

1986 • 106 citations

Interactions of the A1 heterogeneous nuclear ribonucleoprotein and its proteolytic derivative, UP1, with RNA and DNA: Evidence for multiple RNA binding domains and salt-dependent binding mode transitions

1991 • 78 citations

RNA-protein interactions

1991 • 71 citations

MER1, a yeast gene required for chromosome pairing and genetic recombination, is induced in meiosis.

1990 • 70 citations

Complete cDNA sequence of chicken vigilin, a novel protein with amplified and evolutionary conserved domains

1992 • 66 citations

Human hypoxanthine-guanine phosphoribosyltransferase.

1983 • 65 citations

Primary structure of protein S19 from the small ribosomal subunit of Escherichia coli

1978 • 57 citations

The nucleolar protein, B-36, contains a glycine and dimethylarginine-rich sequence conserved in several other nuclear RNA-binding proteins

1988 • 53 citations

Cloning of a full-length complementary DNA for an Artemia salina glycine-rich protein. Structural relationship with RNA binding proteins.

1987 • 53 citations

Fragile X syndrome: The molecular picture comes into focus

1992 • 37 citations

A yeast protein HX has homologies with the histone H2AF expressed in chicken embryo

1986 • 29 citations

Human hypoxanthine-guanine phosphoribosyltransferase. Detection of a mutant allele by restriction endonuclease analysis.

1983 • 24 citations

The primary structure of protein S3 from the small ribosomal subunit of Escherichia coli

1979 • 22 citations

Ribosomal protein gene cluster of Halobacterium halobium: nucleotide sequence of the genes coding for S3 and L29 equivalent ribosomal proteins

1989 • 20 citations

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