THE ROLE OF THE MUCOSAL IMMUNE SYSTEM IN INFLAMMATORY BOWEL DISEASE

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.

1994 • 2,251 citations

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

1980 • 2,099 citations

Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils.

1989 • 1,993 citations

Integrins and other cell adhesion molecules

1990 • 1,990 citations

Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family

1991 • 1,864 citations

Biology of interleukin 1

1988 • 1,547 citations

Selectins: Interpreters of Cell-Specific Carbohydrate Information During Inflammation

1992 • 1,255 citations

Structure and Functional Expression of a Human Interleukin-8 Receptor

1991 • 1,088 citations

Treatment of Crohn's Disease with 6-Mercaptopurine

1980 • 1,055 citations

Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor.

1988 • 1,039 citations

Immunoglobulin A (IgA): Molecular and Cellular Interactions Involved in IgA Biosynthesis and Immune Response

1987 • 956 citations

Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation

1979 • 928 citations

Cloning of Complementary DNA Encoding a Functional Human Interleukin-8 Receptor

1991 • 878 citations

N-formylmethionyl peptides as chemoattractants for leucocytes.

1975 • 871 citations

The physiological action of β‐iminazolylethylamine

1910 • 867 citations

Interleukin-1 receptor antagonist reduces mortality from endotoxin shock

1990 • 865 citations

Enhand secretion of tumour necrosis factor-alpha, IL-6, and IL-1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease

1993 • 848 citations

The common mucosal immune system and current strategies for induction of immune responses in external secretions

1987 • 810 citations

6-Mercaptopurine in the Management of Inflammatory Bowel Disease: Short- and Long-Term Toxicity

1989 • 757 citations

Enhanced Synthesis of Leukotriene B4 by Colonic Mucosa in Inflammatory Bowel Disease

1984 • 749 citations

Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines.

1992 • 737 citations

Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives

1986 • 731 citations

Complement (C5-a)-induced granulocyte aggregation in vitro. A possible mechanism of complement-mediated leukostasis and leukopenia.

1977 • 696 citations

Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung.

1990 • 678 citations

Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis.

1992 • 667 citations

The biologically active leukotrienes. Biosynthesis, metabolism, receptors, functions, and pharmacology.

1984 • 664 citations

Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid.

1979 • 652 citations

Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes: partial characterization and separation from interleukin 1 (IL 1).

1987 • 613 citations

The presence of histamine in tissue mast cells

1953 • 611 citations

Chemotactic response to human C3a and C5a anaphylatoxins. I. Evaluation of C3a and C5a leukotaxis in vitro and under stimulated in vivo conditions.

1978 • 567 citations

Mechanisms of Lysosomal Enzyme Release from Human Leukocytes II. EFFECTS OF cAMP AND cGMP, AUTONOMIC AGONISTS, AND AGENTS WHICH AFFECT MICROTUBULE FUNCTION

1974 • 567 citations

Immunobiology and immunopathology of human gut mucosa: Humoral immunity and intraepithelial lymphocytes

1989 • 552 citations

Prostaglandins modulate macrophage Ia expression

1982 • 545 citations

A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease

1990 • 528 citations

Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli.

1984 • 520 citations

Methotrexate Induces Clinical and Histologic Remission in Patients with Refractory Inflammatory Bowel Disease

1989 • 515 citations

Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene.

1987 • 509 citations

Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine

1990 • 489 citations

Role of prostaglandins in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine.

1978 • 454 citations

Neutrophil-mediated mucosal injury

1988 • 445 citations

Characterization of two high affinity human interleukin-8 receptors.

1992 • 435 citations

STUDIES ON HUMAN ANTIBODIES

1968 • 435 citations

The pharmacological basis of therapeutics

1977 • 434 citations

Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease

1989 • 433 citations

Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis of Crohn's disease.

1989 • 430 citations

AUTOANTIBODIES IN HUMAN ULCERATIVE COLITIS

1959 • 422 citations

CARCINOID SYNDROME

1961 • 405 citations

Role of interleukin 1 in inflammatory bowel disease--enhanced production during active disease.

1990 • 402 citations

Chemotaxis and inflammation

1974 • 397 citations

Chemotactic Response to Human C3a and C5a Anaphylatoxins

1978 • 393 citations

Activation of human neutrophils with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycerol-3-phosphorylcholine (platelet activating factor).

1981 • 390 citations

A Placebo-Controlled, Double-Blind, Randomized Trial of Cyclosporine Therapy in Active Chronic Crohn's Disease

1989 • 380 citations

Role of Prostaglandins in Ulcerative Colitis

1978 • 376 citations

Recombinant human MCP-1/JE induces chemotaxis, calcium flux, and the respiratory burst in human monocytes

1991 • 369 citations

[Tumor necrosis factor].

1990 • 340 citations

Azathioprine in Ulcerative Colitis: Final Report on Controlled Therapeutic Trial

1974 • 338 citations

Fundamental immunology

1984 • 334 citations

Interleukin 1 (IL-1) gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbit immune complex colitis.

1990 • 333 citations

Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification

1992 • 323 citations

Preliminary report: cyclosporin in treatment of severe active ulcerative colitis

1990 • 321 citations

Dexamethasone inhibition of interleukin 1 beta production by human monocytes. Posttranscriptional mechanisms.

1988 • 317 citations

CONTROLLED TRIAL OF AZATHIOPRINE IN CROHN'S DISEASE

1971 • 316 citations

Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor.

1988 • 300 citations

A Neutrophil Chemotactic Factor from Human C′5

1969 • 297 citations

Mechanisms regulating IgA class-specific immunoglobulin production in murine gut-associated lymphoid tissues. I. T cells derived from Peyer's patches that switch sIgM B Cells to sIgA B cells in vitro

1983 • 287 citations

Intestinal lymphocyte subpopulations in inflammatory bowel disease: an analysis by immunohistological and cell isolation techniques.

1984 • 273 citations

Absorption of 151chromium-labeled ethylenediaminetetraacetate in inflammatory bowel disease

1983 • 272 citations

The Isolation and Partial Characterization of Neutrophil Chemotactic Factors from Escherichia Coli

1975 • 268 citations

Effects of topical 5-aminosalicylic acid and prednisolone on prostaglandin E2 and leukotriene B4 levels determined by equilibrium in vivo dialysis of rectum in relapsing ulcerative colitis

1986 • 266 citations

Motility and Adhesiveness in Human Neutrophils

1979 • 264 citations

Glucocorticoids downregulate gene expression of GM-CSF, NAP-1/IL-8, and IL-6, but not of M-CSF in human fibroblasts

1992 • 263 citations

Marked synergism between tumor necrosis factor-alpha and interferon-gamma in regulation of keratinocyte-derived adhesion molecules and chemotactic factors.

1990 • 261 citations

Pathobiology of the intravenous infusion of acetyl glyceryl ether phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF), in the rabbit.

1980 • 259 citations

Subclass restriction of murine antibodies. II. The IgG plaque-forming cell response to thymus-independent type 1 and type 2 antigens in normal mice and mice expressing an X-linked immunodeficiency.

1980 • 258 citations

Enhanced production of neutrophil-activating peptide-1/interleukin-8 in rheumatoid arthritis.

1991 • 256 citations

Vasoactive properties of acetyl glyceryl ether phosphorylcholine and analogues.

1982 • 250 citations

Increased expression of the interleukin-8 gene by alveolar macrophages in idiopathic pulmonary fibrosis. A potential mechanism for the recruitment and activation of neutrophils in lung fibrosis.

1991 • 249 citations

Neutrophil-endothelial cell interactions. Modulation of neutrophil adhesiveness induced by complement fragments C5a and C5a des arg and formyl-methionyl-leucyl-phenylalanine in vitro.

1984 • 248 citations

Controlled trial of azathioprine in chronic ulcerative colitis.

1982 • 238 citations

IN VITRO STUDIES OF ULCERATIVE COLITIS

1963 • 237 citations

Clinical Evidence Supporting the Radical Scavenger Mechanism of 5-Aminosalicylic Acid

1990 • 230 citations

Sulfasalazine inhibits the synthesis of chemotactic lipids by neutrophils.

1982 • 227 citations

Deficiency of the tryptase-positive, chymase-negative mast cell type in gastrointestinal mucosa of patients with defective T lymphocyte function.

1987 • 223 citations

Enhanced thromboxane A2 and prostacyclin production by cultured rectal mucosa in ulcerative colitis and its inhibition by steroids and sulfasalazine

1981 • 218 citations

Interleukin 8 (monocyte-derived neutrophil chemotactic factor) dynamically regulates its own receptor expression on human neutrophils.

1990 • 213 citations

Biosynthesis and biological activity of leukotriene B5

1984 • 209 citations

Increased activation of isolated intestinal lamina propria mononuclear cells in inflammatory bowel disease

1991 • 207 citations

Enhanced synthesis of neutrophil-activating peptide-I/interleukin-8 in active ulcerative colitis

1992 • 206 citations

A controlled trial of azathioprine in Crohn's disease

1975 • 205 citations

Role of platelet-activating factor in ulcerative colitis

1988 • 198 citations

Expression of leukocyte adhesion molecules by mucosal mononuclear phagocytes in inflammatory bowel disease

1991 • 197 citations

Immunohistochemical Characterization of Local Immunoglobulin Formation in Ulcerative Colitis

1974 • 196 citations

A mouse T cell product that preferentially enhances IgA production. I. Biologic characterization.

1987 • 196 citations

Characteristics of human basophil sulfidopeptide leukotriene release: releasability defined as the ability of the basophil to respond to dimeric cross-links.

1986 • 195 citations

Activation of peripheral blood and intestinal lamina propria lymphocytes in Crohn's disease. In vivo state of activation and in vitro response to stimulation as defined by the expression of early activation antigens.

1987 • 182 citations

Functional characterization of human T lymphocyte subsets distinguished by monoclonal anti-leu-8.

1985 • 180 citations

Immunoglobulin G (IgG) subclasses and human disease

1984 • 178 citations

Acetyl glyceryl ether phosphorylcholine stimulates leukotriene B4 synthesis in human polymorphonuclear leukocytes.

1982 • 177 citations

Metabolic, membrane, and functional responses of human polymorphonuclear leukocytes to platelet-activating factor

1982 • 177 citations

Inhibition of polymorphonuclear leukocyte adherence by prostacyclin.

1980 • 177 citations

Familial empiric risk estimates of inflammatory bowel disease in Ashkenazi Jews

1989 • 174 citations

Association of the Human Lymphocyte-DR2 Antigen with Japanese Ulcerative Colitis

1982 • 170 citations

Chemokines and serpentines: the molecular biology of chemokine receptors

1993 • 167 citations

Comparative mapping of the local distribution of immunoglobulin-containing cells in ulcerative colitis and Crohn's disease of the colon.

1975 • 167 citations

Alterations of the Immune System in Ulcerative Colitis and Crohn's Disease

1988 • 160 citations

Alterations of IgM, IgG, and IgA Synthesis and Secretion by Peripheral Blood and Intestinal Mononuclear Cells from Patients with Ulcerative Colitis and Crohn's Disease

1981 • 157 citations

The molecular species distribution of platelet-activating factor synthesized by rabbit and human neutrophils.

1984 • 155 citations

Mucosal subclass distribution of immunoglobulin G-producing cells is different in ulcerative colitis and Crohn's disease of the colon

1987 • 155 citations

Interleukin-6 and its receptor are expressed in human intestinal epithelial cells

1989 • 150 citations

Triggered human mucosal T cells release tumour necrosis factor-alpha and interferon-gamma which kill human colonic epithelial cells

1991 • 149 citations

IMMUNOLOGICAL STUDIES IN ULCERATIVE COLITIS

1968 • 148 citations

Human IgG subclasses in health and disease (A review)Part I

1980 • 146 citations

Secretion by human fibroblasts of monocyte chemoattractant protein-1, the product of gene JE.

1990 • 145 citations

Scintigraphic assessment of bowel involvement and disease activity in Crohn's disease using technetium 99m-hexamethyl propylene amine oxine as leukocyte label

1988 • 143 citations

Epithelial Deposition of Immunoglobulin G1 and Activated Complement (C3b and Terminal Complement Complex) in Ulcerative Colitis

1990 • 143 citations

Spontaneous secretion of IgG subclasses by intestinal mononuclear cells: differences between ulcerative colitis, Crohn's disease, and controls.

1986 • 143 citations

Enhanced Local Production of Complement Components in the Small Intestines of Patients with Crohn's Disease

1990 • 142 citations

The Effects of the Immunologic Release of Histamine upon Human Lung Cyclic Nucleotide Levels and Prostaglandin Generation

1978 • 141 citations

Geographic origins of Jewish patients with inflammatory bowel disease

1989 • 141 citations

Importance of the amino terminus of the interleukin-8 receptor in ligand interactions.

1993 • 141 citations

Identification of high affinity receptors for human monocyte chemoattractant protein-1 on human monocytes.

1990 • 140 citations

Chemotaxis and Inflammation

1983 • 140 citations

Vascular actions of synthetic PAF-acether (a synthetic platelet-activating factor) in the rat: Evidence for a platelet independent mechanism

1982 • 138 citations

IN VITRO STUDIES OF ULCERATIVE COLITIS

1963 • 138 citations

Rectal mucosal prostaglandin E2 release and its relation to disease activity, electrical potential difference, and treatment in ulcerative colitis.

1980 • 137 citations

Phenotypic analysis of lamina propria lymphocytes. Predominance of helper-inducer and cytolytic T-cell phenotypes and deficiency of suppressor-inducer phenotypes in Crohn's disease and control patients.

1986 • 135 citations

Effect of sulphasalazine and its metabolites on the generation of reactive oxygen species.

1987 • 135 citations

Mechanisms regulating IgA class-specific immunoglobulin production in murine gut-associated lymphoid tissues. II. Terminal differentiation of postswitch sIgA-bearing Peyer's patch B cells.

1983 • 133 citations

Saturation kinetics applied to in vitro effects of low prostaglandin E2 and F2α concentrations on ion transport across human jejunal mucosa

1980 • 133 citations

Characterization of a receptor for human monocyte-derived neutrophil chemotactic factor/interleukin-8.

1990 • 131 citations

Suppression of immune complex vasculitis in rats by prostaglandin.

1979 • 129 citations

THE DEPRESSION OF PHAGOCYTOSIS BY EXOGENOUS CYCLIC NUCLEOTIDES, PROSTAGLANDINS, AND THEOPHYLLINE

1973 • 129 citations

Interleukin 1 in Crohn's disease.

1987 • 127 citations

Prostaglandin synthesis inhibitors in ulcerative colitis: Flurbiprofen compared with conventional treatment

1981 • 127 citations

Lymphoepithelial interactions in the mucosal immune system.

1988 • 125 citations

Respiratory burst activity of intestinal macrophages in normal and inflammatory bowel disease.

1989 • 125 citations

Production of Peptides Inducing Chemotaxis and Lysosomal Enzyme Release in Human Neutrophils by Intestinal Bacteria in Vitro and in Vivo

1988 • 124 citations

Morphologic basis of increased vascular permeability induced by acetyl glyceryl ether phosphorylcholine.

1984 • 123 citations

Late asthmatic responses: Inquiry into mechanisms and significance

1985 • 122 citations

Mast cells and immunoglobulin E in inflammatory bowel disease.

1975 • 121 citations

Endotoxaemia in active Crohn's disease. Treatment with whole gut irrigation and 5-aminosalicylic acid.

1986 • 119 citations

Prostanoid synthesis by cultured intestinal epithelial and mononuclear cells in inflammatory bowel disease.

1983 • 118 citations

Human intestinal mononuclear cells. I. Investigation of antibody-dependent, lectin-induced, and spontaneous cell-mediated cytotoxic capabilities.

1980 • 118 citations

Significance of immunoglobulin G subclasses

1984 • 118 citations

Histamine release from gut mast cells from patients with inflammatory bowel diseases.

1990 • 118 citations

Enhancement of human intestinal mast cell mediator release in active ulcerative colitis

1990 • 117 citations

Granulocyte aggregometry: a sensitive technique for the detection of C5a and complement activation

1980 • 117 citations

Phenotypic analysis of lamina propria lymphocytes

1986 • 117 citations

Human recombinant macrophage inflammatory protein-1 alpha and -beta and monocyte chemotactic and activating factor utilize common and unique receptors on human monocytes.

1993 • 116 citations

Monocyte aggregation and superoxide anion release in response to formyl-methionyl-leucyl-phenylalanine (FMLP) and platelet-activating factor (PAF).

1982 • 115 citations

Effect of anti-inflammatory drugs and agents that elevate intracellular cyclic AMP on the release of toxic oxygen metabolites by phagocytes: Studies in a model of tissue-bound IgG

1978 • 114 citations

Identification of RANTES receptors on human monocytic cells: competition for binding and desensitization by homologous chemotactic cytokines.

1993 • 110 citations

Agents That Increase Cyclic AMP Inhibit Accumulation of cGMP and Depress Human Monocyte Locomotion

1978 • 109 citations

Molecular species of platelet-activating factor generated by human neutrophils challenged with ionophore A23187.

1985 • 109 citations

Patients with active Crohn's disease have elevated serum antibodies to antigens of seven enteric bacterial pathogens.

1984 • 109 citations

Remission of Crohn's Disease After Human Immunodeficiency Virus Infection

1988 • 107 citations

Immunoglobulin containing cells in inflammatory bowel disease of the colon: a morphometric and immunohistochemical study.

1980 • 107 citations

New horizons in platelet activating factor research

1987 • 106 citations

Studies of prostaglandins and sulphasalazine in ulcerative colitis

1981 • 105 citations

Characteristics of isolated intestinal mucosal lymphoid cells in inflammatory bowel disease

1979 • 104 citations

A monoclonal antibody directed against the HLA-Bw6 epitope.

1982 • 104 citations

Interleukin-8 and neutrophil markers in colonic mucosa from patients with ulcerative colitis.

1992 • 103 citations

Complement-induced histamine release from human basophils. II. Mechanism of the histamine release reaction.

1976 • 101 citations

In Vitro Studies of Inflammatory Bowel Disease

1976 • 100 citations

B Cell Growth and Differentiation Factors and Mechanism of B Cell Activation

1984 • 99 citations

Modulation of neutrophil oxidative responses to soluble stimuli by platelet-activating factor

1986 • 99 citations

Mediators of Anaphylaxis and Inflammation

1982 • 99 citations

Inhibition of Antibody Secretion by 5-Aminosalicylic Acid

1989 • 98 citations

T-cell activation in Crohn's disease. Increased levels of soluble interleukin-2 receptor in serum and in supernatants of stimulated peripheral blood mononuclear cells.

1990 • 98 citations

Suppression of acute and chronic inflammation in adrenalectomized rats by pharmacologic amounts of prostaglandins

1973 • 96 citations

Lymphocytotoxic Antibody in Inflammatory Bowel Disease

1975 • 95 citations

Patients with active Crohn's disease have elevated serum antibodies to antigens of seven enteric bacterial pathogens

1984 • 95 citations

Studies of human C5a as a mediator of inflammation in normal human skin.

1985 • 95 citations

Covert suppressor T cells in Crohn's disease

1981 • 92 citations

Cutaneous responses to human C 3 anaphylatoxin in man.

1972 • 92 citations

Altered patterns of secretion of monomeric IgA and IgA subclass 1 by intestinal mononuclear cells in inflammatory bowel disease

1986 • 92 citations

Inhibition of leucocyte motility by drugs used in ulcerative colitis.

1981 • 91 citations

Effect of Prostaglandin E2 on Adjuvant Arthritis

1969 • 91 citations

High Prevalence of Antibodies to Intestinal Epithelial Antigens in Patients with Inflammatory Bowel Disease and Their Relatives

1989 • 90 citations

Increased respiratory burst of leukocytes in inflammatory bowel diseases--the analysis of free radical generation by using chemiluminescence probe.

1987 • 89 citations

Characterization of cutaneous vascular permeability induced by platelet-activating factor in guinea pigs and rats and its inhibition by a platelet-activating factor receptor antagonist.

1985 • 89 citations

Bacteriological and endotoxin studies in cases of ulcerative colitis submitted to surgery.

1980 • 88 citations

T lymphocyte subsets in inflammatory bowel disease: peripheral blood.

1983 • 88 citations

Human intestinal mononuclear cells

1980 • 88 citations

Immunological studies in ulcerative colitis. 3. Incidence of antibodies to colon-antigen in ulcerative colitis and other gastro-intestinal diseases.

1966 • 87 citations

Human intestinal mucosal mononuclear cells exhibit lymphokine-activated killer cell activity

1985 • 85 citations

Advances in Mucosal Immunology

1990 • 84 citations

Disorders of B cells and helper T cells in the pathogenesis of the immunoglobulin deficiency of patients with ataxia telangiectasia.

1983 • 83 citations

Inhibition of In Vitro Cytotoxicity of Lymphocytes From Patients with Ulcerative Colitis and Granulomatous Colitis for Allogeneic Colonic Epithelial Cells Using Horse Anti-Human Thymus Serum

1968 • 83 citations

Sulfasalazine inhibition of binding of N-Formyl-Methionyl-Leucyl-Phenylalanine (FMLP) to its receptor on human neutrophils

1984 • 83 citations

Platelet-activating factor (PAF-acether) induced leukotriene C4 formation and luminol dependent chemiluminescence by human eosinophils

1986 • 82 citations

Recent Advances in Crohn’s Disease

1981 • 82 citations

HLA antigens in inflammatory bowel disease

1982 • 82 citations

Phase II trial of copper zinc superoxide dismutase (CuZnSOD) in treatment of Crohn's disease

1989 • 82 citations

Assay of prostaglandin-like substances in faeces and their measurement in ulcerative colitis

1976 • 82 citations

Colonic and small intestinal response to intravenous prostaglandin F2 alpha and E2 in man.

1975 • 81 citations

Peripheral Blood T and B Cells in Chronic Inflammatory Bowel Disease

1974 • 81 citations

Increased neutrophil receptors for and response to the proinflammatory bacterial peptide formyl-methionyl-leucyl-phenylalanine in Crohn's disease

1989 • 81 citations

Inflammatory bowel disease

1989 • 78 citations

Plasma interleukin-2 and a soluble/shed interleukin-2 receptor in serum of patients with Crohn's disease. Effect of cyclosporin.

1990 • 78 citations

Acetyl glyceryl ether phosphorylcholine (platelet‐activating factor) mediates heightened metabolic activity in macrophages

1983 • 76 citations

Sensitization to epithelial antigens in chronic mucosal inflammatory disease. Characterization of human intestinal mucosa-derived mononuclear cells reactive with purified epithelial cell-associated components in vitro.

1985 • 76 citations

Platelet Activating Factor (PAF) induces the oxidative burst in macrophages

1983 • 75 citations

Immunoregulatory Function of Lamina Propria T Cells in Crohn's Disease

1985 • 74 citations

Epidemiology of Crohn's disease in the Jewish population of central Israel, 1970-1980.

1989 • 74 citations

Correlation of histopathologic evidence of disease activity with the presence of immunoglobulin-containing cells in the colons of patients with inflammatory bowel disease

1984 • 74 citations

Suppression of Immunoglobulin Synthesis by Lymphocyte Subpopulations in Patients With Crohn's Disease

1984 • 72 citations

T-cell activation in Crohn's disease

1990 • 71 citations

Interferon ? production by human intestinal mucosal mononuclear cells

1988 • 71 citations

Plasma and tissue interleukin-2 receptor levels in inflammatory bowel disease

1990 • 70 citations

Interleukin 2 receptor expression by macrophages in inflammatory bowel disease.

1988 • 70 citations

Complement-Induced Histamine Release from Human Basophils

1976 • 70 citations

Persistent complement activation in submucosal blood vessels of active inflammatory bowel disease: Immunohistochemical evidence

1989 • 70 citations

RECTAL BLEEDING AND INDOMETHACIN SUPPOSITORIES

1975 • 70 citations

Soluble interleukin-2 receptor in Crohn's disease: relation of serum concentrations to disease activity.

1990 • 69 citations

Anti-inflammatory effects of prostaglandin E1: in vivo modulation of the formyl peptide chemotactic receptor on the rat neutrophil.

1983 • 68 citations

Potentiation of complement (C5a)-induced granulocyte aggregation by cytochalasin B.

1978 • 68 citations

Immune status in Crohn's disease. V. Decreased in vitro natural killer cell activity in peripheral blood.

1980 • 68 citations

Evidence for production of 1-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine concomitantly with platelet-activating factor

1985 • 67 citations

Alkyl-ether phosphoglycerides influence calcium fluxes into human endothelial cells.

1985 • 67 citations

Immune status in Crohn's disease : 3. Peripheral blood B lymphocytes, enumerated by means of F(ab)2-antibody fragments, Null and T lymphocytes

1979 • 66 citations

Scientific basis for the clinical use of superoxide dismutase

1986 • 66 citations

Processing of Bacillus subtilis peptidoglycan by a mouse macrophage cell line

1984 • 66 citations

Similar disturbances in B cell activity and regulatory T cell function in Henoch-Schönlein purpura and systemic lupus erythematosus.

1982 • 64 citations

Assessment of inflammatory bowel disease activity by technetium 99m phagocyte scanning

1988 • 63 citations

HLA-DR antigens on colonic epithelial cells in inflammatory bowel disease: I. Relation to the state of activation of lamina propria lymphocytes and to the epithelial expression of other surface markers.

1987 • 63 citations

Neutrophil degranulation: Evidence pertaining to its mediation by the combined effects of leukotriene B₄, platelet‐activating factor, and 5‐HETE

1985 • 62 citations

Rectal mucosal plasma cells in inflammatory bowel disease.

1983 • 61 citations

Chemotactic peptides modulate adherence of human polymorphonuclear leukocytes to monolayers of cultured endothelial cells.

1986 • 61 citations

Deposits of terminal complement complex (TCC) in muscularis mucosae and submucosal vessels in ulcerative colitis and Crohn's disease of the colon.

1989 • 61 citations

Inflammatory bowel diseases—Basic research and clinical implications

1989 • 60 citations

Lymphokine-activated and natural killer cell activity in human intestinal mucosa.

1985 • 60 citations

Abnormalities of neutrophil function do not cause the migration defect in Crohn's disease.

1981 • 60 citations

C3 metabolism in ulcerative colitis and Crohn's disease.

1977 • 60 citations

B Cell Subsets and Differential Responses to Mitogens

1982 • 60 citations

The Subpopulations of Circulating White Blood Cells in Inflammatory Bowel Disease

1976 • 59 citations

Long-Term Immunosuppressive Treatment in Crohn's Disease

1985 • 58 citations

CD4 positive Leu-8 negative helper-inducer T cells predominate in the human intestinal lamina propria.

1988 • 57 citations

Deficient cell-mediated cytotoxicity and hyporesponsiveness to interferon and mitogenic lectin activation by inflammatory bowel disease peripheral blood and intestinal mononuclear cells

1986 • 57 citations

Heterogeneity of B Cells: Direct Evidence of Selective Triggering of Distinct Subpopulations by Polyclonal Activators

1976 • 57 citations

Involvement of the Immune System in the Pathogenesis of Crohn's Disease

1985 • 56 citations

C3a-induced contraction of guinea pig lung parenchyma: Role of cyclooxygenase metabolites

1983 • 56 citations

J-chain expression is more prominent in immunoglobulin A2 than in immunoglobulin A1 colonic immunocytes and is decreased in both subclasses associated with inflammatory bowel disease

1988 • 55 citations

Anaphylatoxin-mediated contraction of guinea pig lung strips: a nonhistamine tissue response.

1981 • 55 citations

Effects of serum albumin, indomethacin and histamine H₁‐antagonists on Paf‐acether‐induced inflammatory responses in the skin of experimental animals and man

1985 • 54 citations

Fast atom bombardment-mass spectrometric identification of molecular species of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes

1985 • 54 citations

Development and application of a radioimmunoassay for interleukin-8: detection of interleukin-8 in synovial fluids from patients with inflammatory joint disease.

1992 • 54 citations

In vivo assessment of granulocyte migration to diseased bowel in Crohn's disease.

1985 • 53 citations

Suppression of human polymorphonuclear function after intravenous infusion of prostaglandin E1

1981 • 53 citations

Cyclosporin-associated nephropathy in patients with autoimmune diseases

1988 • 53 citations

Controlled trial of disodium cromoglycate in chronic persistent ulcerative colitis.

1978 • 53 citations

Normal human intestinal B lymphocytes. Increased activation compared with peripheral blood.

1989 • 51 citations

Enhancement of the chemotactic activity of human C5a des Arg by an anionic polypeptide ("cochemotaxin") in normal serum and plasma.

1981 • 50 citations

In vitro anticolon antibody production by mucosal or peripheral blood lymphocytes from patients with ulcerative colitis.

1990 • 50 citations

Mitogen-induced human IgG subclass expression.

1984 • 49 citations

Immunological Studies in Ulcerative Colitis

1977 • 48 citations

Human mucosal cytotoxic effector cells

1987 • 48 citations

The effect of leukotriene-B4 receptor antagonist, SC-41930, on acetic acid-induced colonic inflammation

1989 • 48 citations

A study of endotoxemia in ulcerative colitis and Crohn's disease. I. Clinical study.

1978 • 48 citations

HLA-A and -B antigens in inflammatory bowel disease.

1986 • 47 citations

Human Monocyte Chemoattractant Protein-1 (MCP-1)

1991 • 45 citations

T cell-B cell regulation in the intestinal lamina propria in Crohn's disease

1985 • 45 citations

Complement-mediated release of histamine from human basophils. II. Biochemical characterization of the reaction.

1976 • 45 citations

Chemical structure and biological activity relationship of bacterial cell walls and muramyl peptides.

1986 • 44 citations

Immune Status in Crohn's Disease

1978 • 44 citations

Immunosuppression in the treatment of inflammatory bowel disease. II. The effects of azathioprine on lymphoid cell populations in a double blind trial in ulcerative colitis.

1976 • 44 citations

Antiarthritic and Antiinflammatory Effects of Certain Prostaglandins

1972 • 42 citations

SYNTHESIS AND SECRETION OF IgA, IgM, AND IgG BY PERIPHERAL BLOOD MONONUCLEAR CELLS IN HUMAN DISEASE STATES, BY ISOLATED HUMAN INTESTINAL MONONUCLEAR CELLS, AND BY HUMAN BONE MARROW MONONUCLEAR CELLS FROM RIBS*

1983 • 42 citations

Human mucosal T-cell cytotoxicity

1988 • 41 citations

Inhibition of IgE-mediated mast cell degranulation by sulphasalazine

1985 • 40 citations

The Secretory Immune System

1981 • 40 citations

Complement alterations in inflammatory bowel disease

1979 • 40 citations

Comparative trial of sodium cromoglycate enemas with prednisolone enemas in the treatment of ulcerative colitis.

1987 • 40 citations

Polyclonal nature of the intestinal mucosal lymphocyte populations in inflammatory bowel disease

1988 • 39 citations

Disparate regulation of interleukin 8 gene expression from blood monocytes, endothelial cells, and fibroblasts by interleukin 4

1990 • 39 citations

Molecular pathobiology of acetyl glyceryl ether phosphorylcholine: evidence for the structural and functional identity with platelet-activating factor.

1980 • 38 citations

Chemotactic peptide-induced acute colitis in rabbits

1990 • 38 citations

Relationship between Rectal Mucosal Prostaglandin Production and Water and Electrolyte Transport in Ulcerative Colitis

1984 • 38 citations

Defective generation of tetanus-specific antibody-producing B cells after in vivo immunization of Crohn's disease and ulcerative colitis patients

1985 • 38 citations

Mucosal T-Cell Function

1991 • 37 citations

Elevated numbers of peripheral T cells in inflammatory bowel diseases displaying T9 antigen and Fc alpha receptors.

1985 • 37 citations

Immunohistological studies of surface antigen on colonic lymphoid cells in normal and inflamed mucosa

1990 • 35 citations

Inhibition of platelet thromboxane synthetase by sulfasalazine

1983 • 35 citations

Chemotactic activity of C5ades Arg: Evidence of a requirement for an anionic peptide ‘helper factor’ and inhibition by a cationic protein in serum from patients with systemic lupus erythematosus

1980 • 35 citations

Circulating Lymphocyte Subpopulations in Crohn's Disease

1983 • 34 citations

Complement-Mediated Release of Histamine from Human Basophils

1976 • 34 citations

Identification of cell surface receptors for murine macrophage inflammatory protein-1 alpha.

1991 • 34 citations

Activation of neutrophil Chemotaxis by leukotriene B₄and 5-hydroxyeicosatetraenoic acid in chronic inflammatory bowel disease

1987 • 33 citations

Mediators release and function

1984 • 33 citations

Ability of human colonic epithelium to express the 4F2 antigen, the common acute lymphoblastic leukemia antigen, and the transferrin receptor

1989 • 33 citations

Serum inhibitors of leukocyte chemotaxis in Crohn's disease and ulcerative colitis

1982 • 33 citations

Species-specific variations in the molecular heterogeneity of the platelet-activating factor.

1987 • 32 citations

Corticosteroids decrease the expression of beta 2-microglobulin and histocompatibility antigens on human peripheral blood lymphocytes in vitro.

1981 • 32 citations

Neutrophils and mast cells. Comparison of neutrophil-derived histamine-releasing activity with other histamine-releasing factors.

1988 • 32 citations

Marked in vitro spontaneous secretion of IgA by human rib bone marrow mononuclear cells.

1982 • 32 citations

Granulocyte migration in ulcerative colitis

1985 • 32 citations

Local immunity in ulcerative colitis: evidence for defective secretory IgA production.

1988 • 31 citations

Increased in vitro release of soluble interleukin 2 receptor by colonic lamina propria mononuclear cells in inflammatory bowel disease.

1992 • 30 citations

A quantitative study of immunoglobulin containing cells in the differential diagnosis of acute colitis.

1985 • 30 citations

Induction of histamine release and desensitization in human leukocytes. Effect of anaphylatoxin.

1975 • 30 citations

Serum lymphocytotoxins in inflammatory bowel disease. Studies of frequency and specificity for lymphocyte subpopulations.

1975 • 29 citations

Inhibition of cytotoxicity by sulfasalazine. I. Sulfasalazine inhibits spontaneous cell-mediated cytotoxicity by peripheral blood and intestinal mononuclear cells from control and inflammatory bowel disease patients

1986 • 28 citations

Neutrophil degranulation responses to combinations of arachidonate metabolites and platelet-activating factor.

1984 • 28 citations

Hypogammaglobulinemia Due to Abnormal Suppressor T-Cell Activity in Crohn's Disease

1984 • 28 citations

Circulating lipid A antibodies despite absence of systemic endotoxemia in patients with Crohn's disease

1984 • 28 citations

Complement Activation Requirements for Histamine Release from Human Leukocytes: Influence of Purified C3a<sub>hu</sub> and C5a<sub>hu</sub> on Histamine Release

1981 • 28 citations

Cell-mediated immunity in gastrointestinal disease

1986 • 27 citations

Interleukin-1 in the pathogenesis of and protection from inflammatory bowel disease

1989 • 26 citations

Enhanced peripheral blood T-cell cytotoxicity in inflammatory bowel disease

1989 • 26 citations

Evidence that prednisolone is inhibitory to the cyclooxygenase activity of human rectal mucosa

1982 • 26 citations

Inhibition of cytotoxicity by sulfasalazine. II. Sulfasalazine and sulfapyridine inhibit different stages of the NK and NKCF lytic processes

1986 • 25 citations

LYMPHOCYTOTOXIC AND RNA ANTIBODIES IN INFLAMMATORY BOWEL DISEASE: A COMPARATIVE STUDY IN PATIENTS AND THEIR FAMILIES

1976 • 25 citations

Lymphocyte activation in vivo in the intestinal mucosa of patients with Crohn's disease.

1987 • 25 citations

Lymphokines and the Intestinal immune response. Role in Inflammatory Bowel Disease

1989 • 25 citations

Serum antibodies to Escherichia coli in subjects with ulcerative colitis.

1979 • 25 citations

Leucocyte function in ulcerative colitis. Quantitative leucocyte mobilisation to skin windows and in vitro function of blood leucocytes.

1982 • 24 citations

Diverging effects of chemotactic serum peptides and synthetic f-Met-Leu-Phe on neutrophil locomotion and adhesion.

1981 • 24 citations

Cyclosporin in inflammatory bowel disease

1991 • 24 citations

Generation of NAP-1 and related peptides in psoriasis and other inflammatory skin diseases.

1992 • 24 citations

Effect of a leukotriene B4 receptor antagonist on leukotriene B4-induced neutrophil chemotaxis in cavine dermis

1989 • 24 citations

Hypercatabolism of Complement in Crohn's Disease—Assessment of Circulating C3c

1983 • 23 citations

In vitro studies on cellular and humoral chemotaxis in Crohn's disease using the under agarose gel technique.

1981 • 22 citations

Human IgG subclasses in health and disease(A review) Part II

1980 • 22 citations

Defective release of C5a related chemo-attractant activity from complement in Crohn's disease.

1983 • 21 citations

Biopsy histamine in ulcerative colitis and Crohn's disease.

1987 • 21 citations

Lysis of colonic epithelial cells by allogeneic mononuclear and lymphokine activated killer cells derived from peripheral blood and intestinal mucosa: evidence against a pathogenic role in inflammatory bowel disease.

1988 • 20 citations

Activation of Classical Pathway Complement in Chronic Inflammation

1988 • 19 citations

The immunology of idiopathic inflammatory bowel disease.

1986 • 19 citations

Polyclonal nature of the intestinal mucosal lymphocyte populations in inflammatory bowel disease

1988 • 19 citations

Immunstatus bei M. Crohn

1980 • 19 citations

Decreased Expression of HLA‐DR Antigens on Peripheral Blood B Lymphocytes during Glucocorticoid Treatment

1981 • 18 citations

Induction of Histamine Release and Desensitization in Human Leukocytes

1975 • 18 citations

Kinetics of histamine released from rectal mucosa

1989 • 17 citations

Release of leukotriene B4 and 5-hydroxyeicosatetraenoic acid during phagocytosis of artificial immune complexes by peripheral neutrophils in chronic inflammatory bowel disease.

1986 • 16 citations

Use of alpha-tocopherylquinone in the treatment of ulcerative colitis.

1986 • 16 citations

Binding sites for peptidoglycan on mouse lymphocytes

1987 • 14 citations

Nonpathogenicity of antiintestinal antibody in the rabbit.

1976 • 14 citations

Neutrophils and mast cells: Characterization of cells responsive to neutrophil-derived histamine-releasing activity (HRA-N)

1989 • 14 citations

The CD8+ Leu-7+ subset of T cells in Crohn's disease: distinction between cytotoxic and covert suppressor functions

1990 • 12 citations

HLA-D Related Antigens in Inflammatory Bowel Disease

1981 • 11 citations

The Role of Ciclosporin Therapy in Crohn’s Disease

1991 • 11 citations

The Role of the Immune System in Inflammatory Bowel Disease

1988 • 11 citations

Tissue origin of peptide-responsive eicosanoid production in rabbit intestine

1989 • 9 citations

Serum interferon activity in inflammatory bowel disease

1988 • 9 citations

Aggregated bovine IgG inhibits mannose receptor expression of murine bone marrow-derived macrophages via activation.

1991 • 8 citations

Human Intestinal Mononuclear Cells [MNC] Isolated from Normal and Inflammatory Bowel Disease [IBD] Specimens are a Functionally Unique Lymphoid Population

1981 • 8 citations

Activated T cells and macrophages in the intestinal mucosa of children with inflammatory bowel disease

1990 • 8 citations

Studies of Family History in Inflammatory Bowel Disease

1981 • 7 citations

Activated Fc Alpha T Cells in Crohn’s Disease are Involved in Regulation of IgA

1988 • 7 citations

Defective Modulation of Complement in Crohn's Disease: C3b Opsonization of Zymosan by the Alternative Pathway

1985 • 5 citations

Developments in gastroenterology, vol. 1: Recent advances in Crohn's disease

1982 • 5 citations

Role of the CD45 (T-200) molecule in anti-CD3-triggered T cell-mediated cytotoxicity

1988 • 4 citations

[Serum levels of interleukin 6 in patients with inflammatory bowel disease].

1990 • 3 citations

Human rib bone marrow mononuclear cells spontaneously synthesize and secrete IgEin vitro

1991 • 3 citations

The Case of the Prostatic Cancer

1980 • 1 citations