Enhanced Synthesis of Leukotriene B4 by Colonic Mucosa in Inflammatory Bowel Disease

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

1980 • 2,099 citations

Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets

1974 • 1,410 citations

Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.

1981 • 1,030 citations

Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation

1979 • 928 citations

Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid.

1979 • 652 citations

Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases

1976 • 638 citations

Role of prostaglandins in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine.

1978 • 454 citations

Role of Prostaglandins in Ulcerative Colitis

1978 • 376 citations

Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis.

1980 • 350 citations

Metabolism of arachidonic acid in ionophore-stimulated neutrophils. Esterification of a hydroxylated metabolite into phospholipids.

1979 • 297 citations

Sulfasalazine inhibits the synthesis of chemotactic lipids by neutrophils.

1982 • 227 citations

LEUKOTRIENE B4, AN INFLAMMATORY MEDIATOR IN GOUT

1982 • 193 citations

Acetyl glyceryl ether phosphorylcholine stimulates leukotriene B4 synthesis in human polymorphonuclear leukocytes.

1982 • 177 citations

Rectal mucosal prostaglandin E2 release and its relation to disease activity, electrical potential difference, and treatment in ulcerative colitis.

1980 • 137 citations

Effect of various lipoxygenase metabolites of arachidonic acid on degranulation of polymorphonuclear leukocytes.

1981 • 129 citations

Arachidonate metabolism via lipoxygenase and 12L-hydroperoxy-5,8,10,14-icosatetraenoic acid peroxidase sensitive to anti-inflammatory drugs.

1980 • 118 citations

Prostanoid synthesis by cultured intestinal epithelial and mononuclear cells in inflammatory bowel disease.

1983 • 118 citations

METABOLITES OF ARACHIDONIC ACID FORMED BY HUMAN GASTROINTESTINAL TISSUES AND THEIR ACTIONS ON THE MUSCLE LAYERS

1981 • 112 citations

Stimulation of Colonic Secretion by Lipoxygenase Metabolites of Arachidonic Acid

1982 • 110 citations

Studies of prostaglandins and sulphasalazine in ulcerative colitis

1981 • 105 citations

Covert suppressor T cells in Crohn's disease

1981 • 92 citations

Studies on the mechanism of formation of the 5S,12S-dihydroxy-6,8,10,14(E,Z,E,Z)-icosatetraenoic acid in leukocytes

1982 • 84 citations

Assay of prostaglandin-like substances in faeces and their measurement in ulcerative colitis

1976 • 82 citations

Pharmacological effects of non-steroidal antiinflammatory agents on prostaglandin and leukotriene synthesis in mouse peritoneal macrophages

1983 • 57 citations

[50] Preparation of 15-l-hydroperoxy-5,8,11,13-eicosatetraenoic acid (15-HPETE)

1982 • 42 citations

Differential effects of anti-inflammatory drugs on lipoxygenase and cyclo-oxygenase activities of neutrophils from a reverse passive Arthus reaction

1983 • 40 citations

Arachidonic acid metabolism and colonic secretion

1983 • 7 citations

Chemotactic factors in the stool of patients with ulcerative colitis

1980 • 4 citations