Effect of sulphasalazine and its metabolites on the generation of reactive oxygen species.

AN EXPERIMENT TO DETERMINE THE ACTIVE THERAPEUTIC MOIETY OF SULPHASALAZINE

1977 • 815 citations

Ischemic injury in the cat small intestine: Role of superoxide radicals

1982 • 771 citations

H2O2 Release from Human Granulocytes during Phagocytosis

1977 • 586 citations

Phagocytic activation of a luminol-dependent chemiluminescence in rabbit alveolar and peritoneal macrophages

1976 • 572 citations

Role of prostaglandins in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine.

1978 • 454 citations

The Biology and Pathology of Oxygen Radicals

1978 • 437 citations

Role of Prostaglandins in Ulcerative Colitis

1978 • 376 citations

Therapeutic Efficacy of Sulfasalazine and Its Metabolites in Patients with Ulcerative Colitis and Crohn's Disease

1980 • 318 citations

Distribution Studies of Salicylazosulfapyridine and its Metabolites

1973 • 253 citations

Elaboration of toxic oxygen by-products by neutrophils in a model of immune complex disease.

1976 • 249 citations

Sulfasalazine inhibits the synthesis of chemotactic lipids by neutrophils.

1982 • 227 citations

Auto-oxidative damage in Behçet's disease--endothelial cell damage following the elevated oxygen radicals generated by stimulated neutrophils.

1982 • 197 citations

Effects of indomethacin, 5,8,11,14-eicosatetraynoic acid, and p-bromophenacyl bromide on lysosomal enzyme release and superoxide anion generation by human polymorphonuclear leukocytes

1980 • 153 citations

Colonic Azodisalicylate Metabolism Determined by In Vivo Dialysis in Healthy Volunteers and Patients With Ulcerative Colitis

1984 • 140 citations

Prostaglandin synthesis inhibitors in ulcerative colitis: Flurbiprofen compared with conventional treatment

1981 • 127 citations

Ethylene formation by polymorphonuclear leukocytes. Role of myeloperoxidase.

1978 • 121 citations

Inhibition of superoxide anion production in macrophages by anti-inflammatory drugs

1976 • 111 citations

PROSTAGLANDINS, ULCERATIVE COLITIS, AND SULPHASALAZINE

1975 • 101 citations

Sulfasalazine

1975 • 96 citations

The Effect of Sulfasalazine and Its Active Components on Human Polymorphonuclear Leukocyte Function in Relation to Ulcerative Colitis

1979 • 86 citations

Effects of sulphasalazine and disodium azodisalicylate on colonic PGE2 concentrations determined by equilibrium in vivo dialysis of faeces in patients with ulcerative colitis and healthy controls.

1984 • 85 citations

Dissociation of the inhibitory effect of dapsone on the generation of oxygen intermediates—in comparision with that of colchicine and various scavengers

1984 • 80 citations

Determination of prostaglandin synthetase activity in rectal biopsy material and its significance in colonic disease.

1978 • 75 citations

EFFECTS OF SULPHASALAZINE AND ITS METABOLITES ON PROSTAGLANDIN SYNTHESIS, INACTIVATION AND ACTIONS ON SMOOTH MUSCLE

1980 • 75 citations

Neutrophil-Generated Active Oxygens in Linear IgA Bullous Dermatosis

1985 • 73 citations

Prostaglandin synthetase activity in acute ulcerative colitis: effects of treatment with sulphasalazine, codeine phosphate and prednisolone.

1979 • 71 citations

Hydroxyl-free radicals and anti-inflammatory drugs: biological inactivation studies and reaction rate constants

1983 • 53 citations

EFFECT OF CYTOCHALASIN B ON RESPONSE OF HUMAN POLYMORPHONUCLEAR LEUKOCYTES TO ZYMOSAN

1973 • 48 citations

Effects of psoriatic sera on the generation of oxygen intermediates by normal polymorphonuclear leucocytes

1983 • 36 citations

Auto-oxidative damage in cement dermatitis

1985 • 32 citations

Effects of thalidomide on the generation of oxygen intermediates by zymosan-stimulated normal polymorphonuclear leukocytes

1982 • 26 citations

Increased hydroxyl radical generation by normal polymorphonuclear leukocytes incubated in sera from patients with leukocytoclastic vasculitis

1982 • 26 citations

Arachidonic acid-induced chemiluminescence of human polymorphonuclear leukocytes

1982 • 23 citations

Selective actions of aspirin- and sulphasalazine-like drugs against prostaglandin synthesis and breakdown

1982 • 15 citations

Erythema multiforme: a possible pathogenetic role of increased reactive oxygen species.

1986 • 9 citations

Salazosulfapyridine and non-steroidal antiinflammatory drugs do not inhibit soybean lipoxygenase

1985 • 9 citations

Deleted Work

1955 • 0 citations