Lymphocyte Death, p53, and the Problem of the “Undead” Cell

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions*

1984 • 3,073 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

1990 • 1,228 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Apoptosis

1993 • 972 citations

Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.

1987 • 923 citations

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

1984 • 884 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

1993 • 799 citations

Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells

1992 • 784 citations

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit

1993 • 778 citations

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.

1993 • 770 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

1992 • 689 citations

High levels of p53 protein in UV-irradiated normal human skin.

1993 • 689 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

Fas transduces activation signals in normal human T lymphocytes.

1993 • 521 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice.

1993 • 471 citations

Germinal centres in T-cell-dependent antibody responses

1992 • 442 citations

Effect of bcl-2 on Fas antigen-mediated cell death.

1993 • 442 citations

Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

1993 • 440 citations

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.

1993 • 410 citations

Inhibition of DNA replication factor RPA by p53

1993 • 380 citations

Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen

1990 • 375 citations

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.

1990 • 353 citations

Enhanced proliferative potential in culture of cells from p53-deficient mice.

1993 • 341 citations

Sequential expression of protooncogenes during lectin-stimulated mitogenesis of normal human lymphocytes.

1986 • 335 citations

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

1993 • 329 citations

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

1992 • 328 citations

Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning

1993 • 322 citations

Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents

1993 • 305 citations

The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system.

1992 • 303 citations

Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene.

1994 • 295 citations

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

1994 • 276 citations

Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase.

1992 • 274 citations

The p53 protein is an unusually shaped tetramer that binds directly to DNA.

1993 • 252 citations

p53-catalyzed annealing of complementary single-stranded nucleic acids.

1993 • 225 citations

Cell cycle analysis of p53-induced cell death in murine erythroleukemia cells.

1993 • 196 citations

SV40-53K antigen: A possible role for 53K in normal cells

1981 • 187 citations

Antigen-induced apoptosis in developing t cells: a mechanism for negative selection of the t cell receptor repertoire*

1989 • 186 citations

Subcellular distribution of the p53 protein during the cell cycle of Balb/c 3T3 cells.

1990 • 170 citations

Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif.

1993 • 162 citations

Oligomerization of oncoprotein p53

1988 • 158 citations

p53 interacts with p34cdc2 in mammalian cells: implications for cell cycle control and oncogenesis.

1990 • 156 citations

A possible role for bcl-2 in regulating T-cell memory - a ‘balancing act’ between cell death and survival

1993 • 131 citations

T-cell development and transmembrane signaling: changing biological responses through an unchanging receptor

1991 • 113 citations

Stabilised p53 facilitates aneuploid clonal divergence in colorectal cancer.

1993 • 102 citations

Origin of CD4-CD8-B220+ T cells in MRL-lpr/lpr mice. Clues from a T cell receptor beta transgenic mouse.

1993 • 98 citations

Chromosomal destabilization during gene amplification.

1990 • 94 citations

Lymphocyte-triggered internal target disintegration

1991 • 75 citations

Wild type p53 functions as a control protein in the differentiation pathway of the B-cell lineage.

1993 • 75 citations

Immunohistochemical analysis of p53 expression in malignant lymphomas.

1992 • 68 citations

Wild-type p53 is required for apoptosis induced by growth factor deprivation in factor-dependent leukaemic cells

1994 • 62 citations

Interleukin 7-dependent B lymphocyte precursor cells are ultrasensitive to apoptosis.

1994 • 61 citations

Peripheral T lymphocyte depletion by apoptosis after CD4 ligationin vivo: selective loss of CD44− and ‘activating’ memory T cells

1994 • 58 citations

HOME: Highly optimized microscope environment

1992 • 52 citations

Isolation and characterization of DNA sequences that are specifically bound by wild-type p53 protein.

1993 • 37 citations

Expression, methylation and chromatin structure of the p53 gene in untransformed and human T-cell leukemia virus type I-transformed human T-lymphocytes.

1989 • 24 citations

Human CD4 Modulation in Vivo Induced by Antibody Treatment

1993 • 22 citations