Chromosomal destabilization during gene amplification.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

The Significance of Responses of the Genome to Challenge

1984 • 2,520 citations

Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4.

1988 • 1,334 citations

CHROMOSOME ORGANIZATION AND GENIC EXPRESSION

1951 • 1,174 citations

THE MOLECULAR STRUCTURE OF CENTROMERES AND TELOMERES

1984 • 693 citations

Sensitive, high-resolution chromatin and chromosome mapping in situ: Presence and orientation of two closely integrated copies of EBV in a lymphoma line

1988 • 550 citations

Recent progress in understanding mechanisms of mammalian DNA amplification

1989 • 469 citations

EUKARYOTIC CHROMOSOME REPLICATION

1975 • 455 citations

Three-dimensional architecture of a polytene nucleus

1983 • 453 citations

Transcriptional elements as components of eukaryotic origins of DNA replication

1988 • 341 citations

Deletion of the diploid dihydrofolate reductase locus from cultured mammalian cells

1983 • 293 citations

Gene amplification in cultured cells.

1988 • 289 citations

Human telomeres: fusion and interstitial sites

1989 • 248 citations

Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications.

1986 • 242 citations

Double minute chromosomes can be produced from precursors derived from a chromosomal deletion.

1988 • 236 citations

The importance of circular DNA in mammalian gene amplification.

1989 • 234 citations

Recombinant fragment assay for gene targetting based on the polymerase chain reaction

1988 • 192 citations

Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma.

1986 • 173 citations

Large inverted duplications are associated with gene amplification

1986 • 147 citations

Effect of chromosomal position on amplification of transfected genes in animal cells

1984 • 140 citations

Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line.

1981 • 139 citations

Characterization of an Episome Produced in Hamster Cells that Amplify a Transfected CAD Gene at High Frequency: Functional Evidence for a Mammalian Replication Origin

1987 • 137 citations

Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules.

1988 • 137 citations

Charomids: cosmid vectors for efficient cloning and mapping of large or small restriction fragments.

1986 • 126 citations

The multicopy appearance of a large inverted duplication and the sequence at the inversion joint suggest a new model for gene amplification.

1988 • 125 citations

Telomere replication, kinetochore organizers, and satellite DNA evolution.

1979 • 113 citations

A hotspot for novel amplification joints in a mosaic of Alu-like repeats and palindromic A + T-rich DNA.

1987 • 111 citations

Structure of an inverted duplication formed as a first step in a gene amplification event: implications for a model of gene amplification.

1987 • 104 citations

Isolation of the amplified dihydrofolate reductase domain from methotrexate-resistant Chinese hamster ovary cells.

1987 • 97 citations

Evolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences.

1983 • 96 citations

Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line.

1989 • 96 citations

Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization.

1982 • 91 citations

Structure of DNA formed in the first step of CAD gene amplification.

1986 • 78 citations

Left-handed Z-DNA in bands of acid-fixed polytene chromosomes.

1983 • 75 citations

Chromosomal assignments of the genes coding for human types II, III, and IV collagen: a dispersed gene family.

1985 • 72 citations

Gene amplification in methotrexate-resistant mouse cells

1981 • 66 citations

Circular DNA of 3T6R50 double minute chromosomes

1988 • 65 citations

Formation of an inverted duplication can be an initial step in gene amplification.

1988 • 65 citations

DNA amplification-deletion in a spontaneous mutation of the hamsteraprtlocus: structure and sequence of the novel joint

1986 • 58 citations

Telomere replication and fusion in eukaryotes

1979 • 57 citations

Evolution of karyotypic abnormalities and C-MYC oncogene amplification in human colonic carcinoma cell lines

1985 • 54 citations

In vitro translation of hypoxanthine/guanine phosphoribosyltransferase mRNA: characterization of a mouse neuroblastoma cell line that has elevated levels of hypoxanthine/guanine phosphoribosyltransferase protein.

1981 • 50 citations

Evolution and stability of chromosomal DNA coamplified with the CAD gene.

1989 • 46 citations

Isolation of a gene enhancer within an amplified inverted duplication after "expression selection".

1985 • 46 citations

Gene amplification in methotrexate-resistant mouse cells

1981 • 45 citations

Fluorescent methotrexate labeling and flow cytometric analysis of cells containing low levels of dihydrofolate reductase.

1986 • 30 citations

Model for the formation of double minutes from prematurely condensed chromosomes of replicating micronuclei in drug-treated Chinese hamster ovary cells undergoing DNA amplification.

1989 • 29 citations

Cloning and characterization of DNA sequences amplified in multidrug-resistant Djungarian hamster and mouse cells

1987 • 26 citations

Unstable and stable CAD gene amplification: importance of flanking sequences and nuclear environment in gene amplification.

1987 • 26 citations

Selection of cells with different chromosomal localizations of the amplified c-myc gene during in vivo and in vitro growth of the breast carcinoma cell line SW 613-S

1989 • 25 citations

Unstable expression and amplification of a transfected oncogene in confluent and subconfluent cells.

1985 • 20 citations

Amplified inverted duplications within and adjacent to heterologous selectable DNAS

1989 • 13 citations

Applications of Gene Transfer in the Analysis of Gene Amplification

1986 • 5 citations