Genetic alterations associated with metastatic dissemination and chemoresistance in neuroblastoma

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Association of Multiple Copies of the N-mycOncogene with Rapid Progression of Neuroblastomas

1985 • 1,989 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

1983 • 1,407 citations

Apoptosis in cancer therapy: Crossing the threshold

1994 • 1,351 citations

Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.

1990 • 1,147 citations

Molecular regulation of apoptosis: Genetic controls on cell death

1993 • 923 citations

Apoptosis induced by anticancer drugs

1992 • 861 citations

Association between High Levels of Expression of the TRK Gene and Favorable Outcome in Human Neuroblastoma

1993 • 698 citations

Evolution of tumours and the impact of molecular oncology

1985 • 666 citations

The Sequential Analysis of Cancer Development

1980 • 613 citations

Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion.

1992 • 587 citations

P-Glycoprotein Expression as a Predictor of the Outcome of Therapy for Neuroblastoma

1991 • 447 citations

Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors.

1995 • 421 citations

Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.

1993 • 334 citations

Advances in neuroblastoma research

1980 • 325 citations

N-myc amplification causes down-modulation of MHC class I antigen expression in neuroblastoma

1986 • 297 citations

Expression of CD44R1 adhesion molecule in colon carcinomas and metastases

1993 • 284 citations

Critical factors in the biology of human cancer metastasis.

1995 • 266 citations

High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification.

1991 • 229 citations

Evidence for nm23 RNA overexpression, DNA amplification and mutation in aggressive childhood neuroblastomas.

1993 • 203 citations

Absence of p53 gene mutations in primary neuroblastomas.

1993 • 195 citations

Programmed cell death (apoptosis) and response to anti-cancer drugs

1994 • 185 citations

Neuroblastoma consensus deletion maps to 1p36.1–2

1989 • 172 citations

Expression of CD44 is repressed in neuroblastoma cells.

1991 • 165 citations

There may be two tumor suppressor genes on chromosome arm Ip closely associated with biologically distinct subtypes of neuroblastoma

1994 • 165 citations

Neuroblastoma: Effect of genetic factors on prognosis and treatment

1992 • 152 citations

The N-Myc oncoprotein is associated in vivo with the phosphoprotein Max(p20/22) in human neuroblastoma cells.

1991 • 148 citations

Regulation of Bcl-2 oncoprotein levels with differentiation of human neuroblastoma cells.

1993 • 144 citations

Mutations of the p53 gene are involved in Ewing's sarcomas but not in neuroblastomas.

1993 • 138 citations

Expression of the multidrug resistance, MDR1, gene in neuroblastomas.

1990 • 132 citations

Augmented MYCN expression advances the malignant phenotype of human neuroblastoma cells: evidence for induction of autocrine growth factor activity.

1990 • 131 citations

Expression of p53 in human neuroblastoma- and neuroepithelioma-derived cell lines.

1992 • 117 citations

Correlation of MDR1 Gene Expression With Chemotherapy in Neuroblastoma

1989 • 112 citations

Intrinsic or acquired drug resistance and metastasis: Are they linked phenotypes?

1994 • 108 citations

Combined analysis of DNA ploidy index and N-myc genomic content in neuroblastoma.

1991 • 103 citations

Mutation of the p53 gene in neuroblastoma and its relationship with N-myc amplification.

1993 • 90 citations

CD44H expression by human neuroblastoma cells: relation to MYCN amplification and lineage differentiation.

1994 • 76 citations

Very-high-dose cisplatin and etoposide in children with untreated advanced neuroblastoma.

1988 • 67 citations

Coactivation of the MDR1 and MYCN genes in human neuroblastoma cells during the metastatic process in the nude mouse.

1994 • 62 citations

N-myc disrupts protein kinase C-mediated signal transduction in neuroblastoma.

1991 • 56 citations

N-myc genomic content and DNA ploidy in stage IVS neuroblastoma.

1991 • 52 citations

Increased N-myc expression following progressive growth of human neuroblastoma.

1986 • 45 citations

P-glycoprotein associated expression of c-fos and c-jun products in human lung carcinomas.

1993 • 23 citations

Tumor cell progression and differentiation in metastasis.

1991 • 23 citations

Trk mRNA and low affinity nerve growth factor receptor mRNA expression and triploid DNA content in favorable neuroblastoma tumors.

1994 • 23 citations

Stability of phenotypic and genotypic traits during the establishment of a human neuroblastoma cell line, IGR‐N‐835

1989 • 21 citations

Oncogene and MDR1 gene expression in rat rhabdomyosarcoma sublines of different metastatic potential.

1991 • 18 citations

Human Neuroblastoma: Recent Advances in Clinical and Genetic Analysis

1993 • 12 citations

Expression of N-myc, c-myc, and MDR-1 proteins in newly established neuroblastoma cell lines: a study by immunofluorescence staining and flow cytometry.

1992 • 8 citations

Deleted Work

1955 • 0 citations