CD44 splice variants: metastases meet lymphocytes

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

CD44 is the principal cell surface receptor for hyaluronate

1990 • 2,433 citations

A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

1991 • 1,685 citations

LEUKOCYTE ADHESION DEFICIENCY: An Inherited Defect in the Mac-1, LFA-1, and p150,95 Glycoproteins

1987 • 1,147 citations

The Lymphocyte Function Associated LFA-1, CD2, and LFA-3 Molecules: Cell Adhesion Receptors of the Immune System

1987 • 1,104 citations

Lymphocyte interactions with endothelial cells

1992 • 689 citations

Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition.

1990 • 639 citations

Regulated expression and binding of three VLA (β1) integrin receptors on T cells

1990 • 634 citations

A Synthetic Peptide from Fibronectin Inhibits Experimental Metastasis of Murine Melanoma Cells

1986 • 634 citations

The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells.

1991 • 587 citations

Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85-95-kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, mucosal, or synovial endothelial cells.

1987 • 554 citations

A lymphoid cell surface glycoprotein involved in endothelial cell recognition and lymphocyte homing in man

1986 • 435 citations

Participation in Normal Immune Responses of a Metastasis-Inducing Splice Variant of CD44

1992 • 417 citations

The hyaluronate receptor is a member of the CD44 (H-CAM) family of cell surface glycoproteins [published erratum appears in J Cell Biol 1991 Feb;112(3):following 513]

1990 • 368 citations

A human homologue of the rat metastasis-associated variant of CD44 is expressed in colorectal carcinomas and adenomatous polyps.

1993 • 352 citations

Prevention of tumor metastasis formation by anti-variant CD44.

1993 • 339 citations

In Vitro and in Vivo Consequences of VLA-2 Expression on Rhabdomyosarcoma Cells

1991 • 323 citations

A Distinct Endothelial Cell Recognition System That Controls Lymphocyte Traffic into Inflamed Synovium

1986 • 317 citations

Distinct effects of two CD44 isoforms on tumor growth in vivo.

1991 • 315 citations

Inhibition of in vitro tumor cell invasion by Arg-Gly-Asp-containing synthetic peptides [published erratum appears in J Cell Biol 1989 Jun;108(6):following 2546]

1988 • 311 citations

Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44.

1993 • 309 citations

Splicing choice from ten variant exons establishes CD44 variability

1993 • 291 citations

Multiple variants of the human lymphocyte homing receptor CD44 generated by insertions at a single site in the extracellular domain.

1992 • 236 citations

The transmembrane hyaluronate receptor (CD44): multiple functions, multiple forms.

1991 • 224 citations

The two major CD44 proteins expressed on a metastatic rat tumor cell line are derived from different splice variants: each one individually suffices to confer metastatic behavior.

1993 • 223 citations

The Biology of hyaluronan

1989 • 222 citations

Alterations in integrin receptor expression on chemically transformed human cells: specific enhancement of laminin and collagen receptor complexes.

1990 • 213 citations

Triggering of the CD44 antigen on T lymphocytes promotes T cell adhesion through the LFA-1 pathway.

1990 • 185 citations

Monoclonal antibody to a human brain‐granulocyte‐T lymphocyte antigen probably homologous to the W 3/13 antigen of the rat

1980 • 184 citations

Molecular cloning of CD44R1 and CD44R2, two novel isoforms of the human CD44 lymphocyte "homing" receptor expressed by hemopoietic cells.

1991 • 182 citations

Monoclonal antibody and synthetic peptide inhibitors of human tumor cell migration.

1990 • 176 citations

A link between ras and metastatic behavior of tumor cells: ras induces CD44 promoter activity and leads to low-level expression of metastasis-specific variants of CD44 in CREF cells.

1993 • 148 citations

Spontaneous fusion in vivo between normal host and tumor cells: possible contribution to tumor progression and metastasis studied with a lectin-resistant mutant tumor.

1983 • 145 citations

Molecular isoforms of murine CD44 and evidence that the membrane proximal domain is not critical for hyaluronate recognition.

1992 • 129 citations

Inhibition of tumor growth in vivo with a soluble CD44-immunoglobulin fusion protein.

1992 • 126 citations

Cell adhesion receptor expression during melanoma progression and metastasis

1991 • 125 citations

Roll, roll, roll your leucocyte gently down the vein.

1992 • 117 citations

Involvement of LFA-1 in lymphoma invasion and metastasis demonstrated with LFA-1-deficient mutants.

1989 • 111 citations

Structural heterogeneity of human Pgp-1 and its relationship with p85

1988 • 97 citations

Mechanisms of Human Lymphocyte Migration and their Role in the Pathogenesis of Disease

1989 • 95 citations

Identification of a widely distributed 90-kDa glycoprotein that is homologous to the Hermes-1 human lymphocyte homing receptor.

1989 • 95 citations

Expression of a human homing receptor (CD44) in lymphoid malignancies and related stages of lymphoid development.

1990 • 85 citations

Invasiveness of T-cell hybridomas in vitro and their metastatic potential in vivo.

1985 • 62 citations

Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion

1993 • 39 citations

Production of Self-directed Antibody by Tumour Cells

1968 • 7 citations