Human Interleukin-3 (IL-3) Induces Disulfide-Linked IL-3 Receptor α- and β-Chain Heterodimerization, Which Is Required for Receptor Activation but Not High-Affinity Binding

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

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Structural design and molecular evolution of a cytokine receptor superfamily.

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The Human Hematopoietic Colony-Stimulating Factors

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Dimerization of cell surface receptors in signal transduction

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Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells

1989 • 1,097 citations

IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase

1993 • 730 citations

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

1990 • 650 citations

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

1995 • 641 citations

LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor

1993 • 632 citations

Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for the human IL-3 and GM-CSF receptors

1991 • 617 citations

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.

1993 • 516 citations

JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region.

1994 • 506 citations

Platelet plasma membrane glycoproteins. Evidence for the presence of nonequivalent disulfide bonds using nonreduced-reduced two-dimensional gel electrophoresis.

1977 • 451 citations

Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling.

1993 • 383 citations

Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation.

1992 • 365 citations

Interleukin-3 signals through multiple isoforms of Stat5.

1995 • 327 citations

Subunit promiscuity among hemopoietic growth factor receptors

1991 • 273 citations

High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130.

1994 • 242 citations

Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.

1995 • 220 citations

Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130.

1993 • 206 citations

Stimulation of proliferation, differentiation, and function of human cells by primate interleukin 3.

1987 • 206 citations

Activation and inhibition of erythropoietin receptor function: role of receptor dimerization.

1994 • 201 citations

Orientation of cell-surface antigens in the lipid bilayer of lymphocyte plasma membrane

1977 • 175 citations

Human recombinant granulocyte-macrophage colony-stimulating factor and interleukin 3 cause basophil histamine release.

1988 • 158 citations

Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem cell factor.

1992 • 151 citations

GM-CSF, IL-3 and IL-5: cross-competition on human haemopoietic cells

1992 • 142 citations

A Critical Cytoplasmic Domain of the Interleukin-5 (IL-5) Receptor α Chain and Its Function in IL-5-Mediated Growth Signal Transduction

1994 • 139 citations

Recombinant human interleukin-3 and granulocyte-macrophage colony- stimulating factor show common biological effects and binding characteristics on human monocytes

1989 • 133 citations

Common subunits of cytokine receptors and the functional redundancy of cytokines

1992 • 131 citations

Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines

1992 • 128 citations

Human Interleukin‐3 inhibits the binding of granulocyte‐macrophage colony‐stimulating factor and interleukin‐5 to basophils and strongly enhances their functional activity

1990 • 121 citations

Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF.

1994 • 118 citations

Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist

1996 • 109 citations

[22] Iodine monochloride (ICI) iodination techniques

1983 • 95 citations

A Model for the Interaction of the GM-CSF, IL-3 and IL-5 Receptors with their Ligands

1993 • 92 citations

Reconstituted human granulocyte-macrophage colony-stimulating factor receptor transduces growth-promoting signals in mouse NIH 3T3 cells: comparison with signalling in BA/F3 pro-B cells.

1993 • 86 citations

Activating point mutations in the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors suggest the involvement of beta subunit dimerization and cell type-specific molecules in signalling.

1995 • 84 citations

Neutrophils activated by granulocyte-macrophage colony-stimulating factor express receptors for interleukin-3 which mediate class II expression

1995 • 83 citations

Functional reconstitution of the human interleukin-3 receptor

1992 • 83 citations

Multimeric cytokine receptors: common versus specific functions

1994 • 82 citations

Two contiguous residues in human interleukin-3, Asp21 and Glu22, selectively interact with the alpha- and beta-chains of its receptor and participate in function.

1994 • 81 citations

The receptor for interleukin 3 is selectively induced in human endothelial cells by tumor necrosis factor alpha and potentiates interleukin 8 secretion and neutrophil transmigration.

1993 • 77 citations

Human granulocyte-macrophage colony-stimulating factor receptor signal transduction requires the proximal cytoplasmic domains of the alpha and beta subunits

1993 • 67 citations

A mutation of the common receptor subunit for interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor, and IL-5 that leads to ligand independence and tumorigenicity

1994 • 60 citations

Histidine-367 of the human common beta chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor.

1994 • 56 citations

Dimer- and Oligomerization of the Erythropoietin Receptor by Disulfide Bond Formation and Significance of the Region Near the WSXWS Motif in Intracellular Transport

1993 • 51 citations

A critical role for the cytoplasmic domain of the granulocyte-macrophage colony-stimulating factor alpha receptor in mediating cell growth.

1993 • 46 citations

A low affinity chimeric human alpha/beta-granulocyte-macrophage colony-stimulating factor receptor induces ligand-dependent proliferation in a murine cell line.

1994 • 46 citations

Interferon-gamma upregulates interleukin-3 (IL-3) receptor expression in human endothelial cells and synergizes with IL-3 in stimulating major histocompatibility complex class II expression and cytokine production

1995 • 42 citations

High-Affinity Chimeric Human Granulocyte-Macrophage Colony-Stimulating Factor-Receptor Carrying the Cytoplasmic Domain of the β Subunit But Not the α Subunit Transduces Growth-Promoting Signals in Ba/F3 Cells

1995 • 39 citations

Adhesion to thrombospondin by human embryonic fibroblasts is mediated by multiple receptors and includes a role for glycoprotein 88 (CD36)

1992 • 35 citations

Evidence for the ligand‐induced conversion from a dimer to a tetramer of the granulocyte colony‐stimulating factor receptor

1994 • 30 citations

Human IL-3 receptor signaling: rapid induction of phosphatidylcholine hydrolysis is independent of protein kinase C but dependent on tyrosine phosphorylation in transfected NIH 3T3 cells.

1995 • 20 citations