Apoptosis of hemopoietic cells by the human granulocyte-macrophage colony-stimulating factor mutant E21R.

Proposals for the Classification of the Acute Leukaemias F<scp>rench</scp>‐A<scp>merican</scp>‐B<scp>ritish</scp> (FAB) C<scp>o‐operative</scp> G<scp>roup</scp>

1976 • 5,620 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

The Hemopoietic Colony-stimulating Factors

1995 • 565 citations

Functional Isolation and Characterization of Human Hematopoietic Stem Cells

1995 • 414 citations

Ex vivo expansion and maturation of peripheral blood CD34+ cells into the myeloid lineage

1992 • 365 citations

Expression cloning of a receptor for murine granulocyte colony-stimulating factor

1990 • 362 citations

Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.

1995 • 321 citations

Interaction of the erythropoietin and stem-cell-factor receptors

1995 • 309 citations

Constitutive expression of the granulocyte-macrophage colony-stimulating factor gene in acute myeloblastic leukemia.

1987 • 239 citations

Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.

1995 • 174 citations

Rescue from programmed cell death in leukemic and normal myeloid cells

1991 • 165 citations

Human hematopoietic precursors in long-term culture: single CD34+ cells that lack detectable T cell, B cell, and myeloid cell antigens produce multiple colony-forming cells when cultured with marrow stromal cells.

1990 • 149 citations

GM-CSF, IL-3 and IL-5: cross-competition on human haemopoietic cells

1992 • 142 citations

Characterization of the cell surface receptor for human granulocyte/macrophage colony-stimulating factor.

1986 • 141 citations

Recombinant human interleukin-3 and granulocyte-macrophage colony- stimulating factor show common biological effects and binding characteristics on human monocytes

1989 • 133 citations

Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF.

1994 • 118 citations

Residue 21 of human granulocyte-macrophage colony-stimulating factor is critical for biological activity and for high but not low affinity binding.

1992 • 112 citations

Specific human granulocyte-macrophage colony-stimulating factor antagonists.

1994 • 105 citations

Reconstituted human granulocyte-macrophage colony-stimulating factor receptor transduces growth-promoting signals in mouse NIH 3T3 cells: comparison with signalling in BA/F3 pro-B cells.

1993 • 86 citations

Neutrophils activated by granulocyte-macrophage colony-stimulating factor express receptors for interleukin-3 which mediate class II expression

1995 • 83 citations

Interferon alpha induces rapid tyrosine phosphorylation of the alpha subunit of its receptor.

1992 • 78 citations

Flow cytometric characterization of acute myeloid leukemia: IV. Comparison to the differentiation pathway of normal hematopoietic progenitor cells.

1992 • 75 citations

Identification of residues in the first and fourth helices of human granulocyte-macrophage colony-stimulating factor involved in biologic activity and in binding to the alpha- and beta-chains of its receptor

1994 • 65 citations

Histidine-367 of the human common beta chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor.

1994 • 56 citations

Cytokine expression in adherent layers from patients with myelodysplastic syndrome and acute myelogenous leukemia

1995 • 51 citations

Heterogenous mechanisms of autocrine growth of AML blasts

1989 • 41 citations

Identification of conserved amino acids in the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit critical for function. Evidence for formation of a heterodimeric receptor complex prior to ligand binding.

1994 • 39 citations

Reconstituted Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor Transduces Growth-Promoting Signals in Mouse NIH 3T3 Cells: Comparison with Signalling in BA/F3 Pro-B Cells

1993 • 16 citations

Differential Binding of IL-3 and GM-CSF to Human Monocytes

1992 • 16 citations

Cell-to-cell interaction of cytokine-dependent myeloblastic line constitutively expressing membrane-bound stem cell factor abrogates cytokine dependency partially through granulocyte-macrophage colony- stimulating factor production

1995 • 5 citations