The insulin-like growth factors (IGFs) and IGF binding proteins in postnatal development of murine mammary glands.

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

1993 • 2,880 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

Fibroblast growth factors.

2001 • 1,946 citations

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

1990 • 1,650 citations

Insulin-like Growth Factor (IGF)-binding Protein-3 Induces Apoptosis and Mediates the Effects of Transforming Growth Factor-β1 on Programmed Cell Death through a p53- and IGF-independent Mechanism

1997 • 725 citations

Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality.

1994 • 593 citations

Regulation of embryonic growth and lysosomal targeting by the imprintedIgf2/Mpr gene

1994 • 471 citations

The IGF-I receptor in cell growth, transformation and apoptosis

1997 • 446 citations

The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase.

1994 • 441 citations

Tissue Distribution of Insulin-Like Growth Factor I and II Messenger Ribonucleic Acid in the Adult Rat*

1987 • 418 citations

Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression [published erratum appears in J Cell Biol 1996 Feb;132(4):following 752]

1994 • 405 citations

Analysis of Insulin-Like Growth Factor I Gene Expression in Malignancy: Evidence for a Paracrine Role in Human Breast Cancer

1989 • 403 citations

Role of insulin-like growth factor binding proteins in controlling IGF actions

1998 • 401 citations

Growth-Promoting Interaction of IGF-II with the Insulin Receptor during Mouse Embryonic Development

1997 • 391 citations

Mammary gland development and tumorigenesis in estrogen receptor knockout mice.

1997 • 354 citations

Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice.

1989 • 334 citations

Differential responsiveness of human breast cancer cell lines MCF-7 and T47D to growth factors and 17 beta-estradiol.

1988 • 330 citations

Signaling through the stromal epidermal growth factor receptor is necessary for mammary ductal development

1999 • 260 citations

The Type V Transforming Growth Factor β Receptor Is the Putative Insulin-like Growth Factor-binding Protein 3 Receptor

1997 • 259 citations

Insulin-like growth factor binding protein 3 mediates retinoic acid- and transforming growth factor beta2-induced growth inhibition in human breast cancer cells.

1996 • 257 citations

Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis

1996 • 256 citations

Transforming Growth Factor- β-induced Cell Growth Inhibition in Human Breast Cancer Cells Is Mediated through Insulin-like Growth Factor-binding Protein-3 Action

1995 • 241 citations

Insulin-like growth factor II stimulates cell proliferation through the insulin receptor

1997 • 234 citations

Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor.

1989 • 233 citations

A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation.

1995 • 216 citations

Elucidation of a role for stromal steroid hormone receptors in mammary gland growth and development using tissue recombinants.

1997 • 216 citations

Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model.

1996 • 208 citations

Growth factor messenger RNA expression by human breast fibroblasts from benign and malignant lesions.

1991 • 204 citations

Cloning and in vivo expression of bovine growth hormone receptor mRNA

1990 • 195 citations

Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)

1995 • 190 citations

Insulin-like Growth Factors Regulate Neuronal Differentiation and Survival

1997 • 189 citations

IGF-I: an essential factor in terminal end bud formation and ductal morphogenesis.

2000 • 171 citations

Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression.

1996 • 164 citations

Estradiol enhances the stimulatory effect of insulin-like growth factor-I (IGF-I) on mammary development and growth hormone-induced IGF-I messenger ribonucleic acid.

1995 • 152 citations

Control of milk secretion and apoptosis during mammary involution.

1999 • 148 citations

Mammary gland growth and development from the postnatal period to postmenopause: ovarian steroid receptor ontogeny and regulation in the mouse.

1998 • 144 citations

Rescue of the T-associated maternal effect in mice carrying null mutations in Igf-2 and Igf2r, two reciprocally imprinted genes

1993 • 144 citations

Mammary gland development in prolactin receptor knockout mice.

1997 • 142 citations

The Insulin-Like Growth Factor-I Receptor Signaling Pathways Are Important for Tumorigenesis and Inhibition of Apoptosis

1997 • 137 citations

INFLUENCE OF HORMONES ON LOBULO-ALVEOLAR DIFFERENTIATION OF MOUSE MAMMARY GLANDS IN VITRO

1966 • 123 citations

Overexpression of a Kinase-deficient Transforming Growth Factor-β Type II Receptor in Mouse Mammary Stroma Results in Increased Epithelial Branching

1999 • 122 citations

Evidence That the Mammary Fat Pad Mediates the Action of Growth Hormone in Mammary Gland Development

1998 • 119 citations

Targeted Expression of a Dominant Negative Epidermal Growth Factor Receptor in the Mammary Gland of Transgenic Mice Inhibits Pubertal Mammary Duct Development

1997 • 119 citations

Intact and amino-terminally shortened forms of insulin-like growth factor I induce mammary gland differentiation and development.

1992 • 114 citations

Regulation of mammary morphogenesis: Evidence for extracellular matrix-mediated inhibition of ductal budding by transforming growth factor-β1

1992 • 114 citations

Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice.

1998 • 113 citations

Interactions of High Affinity Insulin-like Growth Factor-binding Proteins with the Type V Transforming Growth Factor-β Receptor in Mink Lung Epithelial Cells

1999 • 107 citations

Early mammary development: growth hormone and IGF-1.

1997 • 104 citations

[37] Techniques for studying development of normal mammary epithelial cells in organ culture

1975 • 101 citations

Role of IGF-I in normal mammary development

1998 • 93 citations

Use of PRKO mice to study the role of progesterone in mammary gland development.

1997 • 92 citations

The Insulin-Like Growth Factors (IGF) and IGF Type I Receptor during Postnatal Growth of the Murine Mammary Gland: Sites of Messenger Ribonucleic Acid Expression and Potential Functions**This work was supported, in part, by NIH Grant DK-48103 (to T.L.W.)

1999 • 86 citations

Role of insulin-like growth factor binding proteins in the control of IGF actions

1995 • 83 citations

IGF and insulin action in the mammary gland: lessons from transgenic and knockout models.

2000 • 77 citations

Antiproliferative actions of insulin-like growth factor binding protein (IGFBP)-3 in human breast cancer cells

1995 • 77 citations

Fibroblast growth factor receptor signalling has a role in lobuloalveolar development of the mammary gland

1997 • 75 citations

Insulin-like growth factor binding proteins: IGF-dependent and -independent effects in the mammary gland.

2000 • 73 citations

IGF-II mRNA and protein are expressed in the stroma of invasive breast cancers: Anin situ hybridization and immunohistochemistry study

1996 • 62 citations

The IGF system during fetal-placental development of the mouse

1998 • 61 citations

Somatomedin-C Substitutes for Insulin for the Growth of Mammary Epithelial Cells from Normal Virgin Mice in Serum-Free Collagen Gel Cell Culture*

1986 • 60 citations

Lobuloalveolar Differentiation in Mouse Mammary Tissues in vitro

1964 • 57 citations

Maintenance of normal rat mammary epithelial cells by insulin and insulin-like growth factor 1

1988 • 56 citations

Introduction: mammary gland involution and apoptosis of mammary epithelial cells.

1999 • 53 citations

Expression of Ovine Insulin-Like Growth Factor-1 (IGF-1) Stimulates Alveolar Bud Development in Mammary Glands of Transgenic Mice

1998 • 51 citations

Programmed cell death in the terminal endbud.

1999 • 38 citations

Strain Differences in Response of the Mouse Mammary Gland to Hormones <italic>In Vitro</italic><xref ref-type="fn" rid="FN2">2</xref>

1970 • 35 citations

Simultaneous occurrence of pregnancylike lobuloalveolar morphogenesis and casein-gene expression in a culture of the whole mammary gland

1981 • 15 citations

Role of Post Translational Modifications in Modifying the Biologic Activity of Insulin Like Growth Factor Binding Proteins

1994 • 14 citations

Expression and Regulation of Insulin-like Growth Factors and Their Binding Proteins in the Normal Breast

1999 • 8 citations