Proliferation dependence of topoisomerase II-mediated drug action

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II

1984 • 1,477 citations

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

1984 • 896 citations

Fractionation of DNA from mammalian cells by alkaline elution

1976 • 838 citations

Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.

1984 • 559 citations

Cleavage of DNA by mammalian DNA topoisomerase II.

1983 • 539 citations

A homogeneous type II DNA topoisomerase from HeLa cell nuclei.

1981 • 361 citations

Qualitative and quantitative aspects of intercalator-induced DNA strand breaks

1979 • 244 citations

Protein-associated DNA breaks in cells treated with adriamycin or ellipticine

1978 • 234 citations

DNA damage as a basis for 4'-demethylepipodophyllotoxin-9-(4,6-O-ethylidene-beta-D-glucopyranoside) (etoposide) cytotoxicity.

1983 • 223 citations

DNA Topoisomerases-Enzymes that Catalyse the Breaking and Rejoining of DNA

1983 • 216 citations

Phosphorylation of DNA topoisomerase II by casein kinase II: modulation of eukaryotic topoisomerase II activity in vitro.

1985 • 214 citations

DNA topoisomerases from rat liver: physiological variations

1983 • 206 citations

Effect of VP-16-213 on the intracellular degradation of DNA in HeLa cells

1976 • 197 citations

Comparison of cytotoxicity and DNA breakage activity of congeners of podophyllotoxin including VP16-213 and VM26: a quantitative structure-activity relationship

1984 • 188 citations

Effects of podophyllotoxin and VP-16-213 on microtubule assembly in vitro and nucleoside transport in HeLa cells

1976 • 187 citations

Rapid incorporation of label from ribonucleoside disphosphates into DNA by a cell-free high molecular weight fraction from animal cell nuclei

1983 • 165 citations

DNA double-strand breaks in mammalian cells after exposure to intercalating agents

1981 • 160 citations

Decatenation of kinetoplast DNA by topoisomerases.

1980 • 159 citations

Adenovirus DNA replication in vitro: synthesis of full-length DNA with purified proteins.

1983 • 148 citations

The replication of kinetoplast DNA networks in Crithidia fasciculata

1978 • 148 citations

Inhibition of epipodophyllotoxin cytotoxicity by interference with topoisomerase-mediated DNA cleavage

1985 • 104 citations

DNA topoisomerase activities in concanavalin A‐stimulated lymphocytes

1984 • 102 citations

Identification of the breakage-reunion subunit of T4 DNA topoisomerase.

1984 • 88 citations

Virus- and cell-encoded tyrosine protein kinases inactivate DNA topoisomerases in vitro

1984 • 78 citations

DNA topoisomerase I and II activities during cell proliferation and the cell cycle in cultured mouse embryo fibroblast (C3H 10T1/2) cells

1985 • 71 citations

Epidermal growth factor-induced topoisomerase(s)

1983 • 64 citations

Isolation and Characterization of Kinetoplast DNA Networks and Minicircles from Crithidia fasciculata*

1974 • 64 citations

Inhibition of etoposide-induced DNA damage and cytotoxicity in L1210 cells by dehydrogenase inhibitors and other agents.

1984 • 51 citations

Evidence for participation of a multiprotein complex in yeast DNA replication in vitro.

1984 • 50 citations