Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Glutamate, nitric oxide and cell-cell signalling in the nervous system

1991 • 2,406 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide

1990 • 1,284 citations

Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.

1991 • 982 citations

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

1991 • 812 citations

Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells

1990 • 700 citations

Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate

1989 • 681 citations

NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.

1990 • 657 citations

N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.

1991 • 572 citations

Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages

1989 • 571 citations

Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein.

1991 • 458 citations

Tissue injury caused by deposition of immune complexes is L-arginine dependent.

1991 • 436 citations

Purification of a Ca²⁺/calmodulin‐dependent nitric oxide synthase from porcine cerebellum

1990 • 433 citations

Brain nitric oxide synthase is a biopterin‐ and flavin‐containing multi‐functional oxido‐reductase

1991 • 422 citations

Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.

1991 • 386 citations

Nitric oxide synthase: Irreversible inhibition by L-N -Nitroarginine in brain and

1991 • 368 citations

Purification of nitric oxide synthase from rat macrophages

1991 • 244 citations

Imbalance of Endothelium-derived Relaxing and Contracting Factors: A New Concept in Hypertension?

1990 • 243 citations

Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine.

1991 • 164 citations

Purification and characterization of a human NO synthase

1991 • 115 citations

Inactivation of macrophage nitric oxide synthase activity by NG-Methyl-L-arginine

1991 • 111 citations

Simultaneous determination of neopterin and creatinine in serum with solid-phase extraction and on-line elution liquid chromatography.

1987 • 102 citations

Reductive activation of phenylalanine hydroxylase and its effect on the redox state of the non-heme iron

1984 • 95 citations

Mechanistic probes of N-hydroxylation of L-arginine by the inducible nitric oxide synthase from murine macrophages

1992 • 79 citations

Stoichiometric reduction of phenylalanine hydroxylase by its cofactor: a requirement for enzymatic activity

1984 • 67 citations

6,6-Dimethylpterins: stable quinoid dihydropterin substrate for dihydropteridine reductase and tetrahydropterin cofactor for phenylalanine hydroxylase

1983 • 55 citations

Studies on 6-methyl-5-deazatetrahydropterin and its 4a adducts

1979 • 43 citations

Enzymes Synthesizing Guanylate Cyclase-Activating Factors in Endothelial Cells, Neuroblastoma Cells, and Rat Brain

1991 • 13 citations

The mechanism of oxidation of 6-methyl-5-carba-5-deazatetrahydropterin. Evidence for the involvement cf a 4a-adduct in the oxidation of tetrahydropterins.

1978 • 9 citations