Cyclic nucleotide dependent phosphorylation of neuronal nitric oxide synthase inhibits catalytic activity

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Glutamate, nitric oxide and cell-cell signalling in the nervous system

1991 • 2,406 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

NITRIC OXIDE: A Physiologic Messenger Molecule

1994 • 2,299 citations

Gases as biological messengers: nitric oxide and carbon monoxide in the brain

1994 • 1,052 citations

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1993 • 1,024 citations

Endothelium‐derived nitric oxide: actions and properties

1989 • 686 citations

Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate

1989 • 681 citations

Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.

1992 • 621 citations

Nitric oxide synthase is a cytochrome P-450 type hemoprotein

1992 • 617 citations

Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages

1989 • 571 citations

Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity.

1993 • 543 citations

Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse

1991 • 509 citations

Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein.

1991 • 458 citations

Brain nitric oxide synthase is a biopterin‐ and flavin‐containing multi‐functional oxido‐reductase

1991 • 422 citations

Nitric oxide: biosynthesis and biological significance

1989 • 421 citations

Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide.

1992 • 368 citations

Phosphorylation and subcellular translocation of endothelial nitric oxide synthase.

1993 • 329 citations

Vulnerability of cultured cortical neurons to damage by excitotoxins: differential susceptibility of neurons containing NADPH-diaphorase

1988 • 309 citations

Neurons Containing NADPH-Diaphorase Are Selectively Resistant to Quinolinate Toxicity

1986 • 292 citations

Endothelial nitric oxide synthase. N-terminal myristoylation determines subcellular localization.

1993 • 275 citations

Phosphorylation by calcium calmodulin-dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase

1991 • 275 citations

Multiple catalytic functions of brain nitric oxide synthase. Biochemical characterization, cofactor-requirement, and the role of N omega-hydroxy-L-arginine as an intermediate

1993 • 260 citations

Identification, purification, and functional reconstitution of the cyclic GMP-dependent channel from rod photoreceptors.

1987 • 239 citations

The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia

1992 • 237 citations

Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase.

1990 • 232 citations

Dual ion-channel regulation by cyclic GMP and cyclic GMP-dependent protein kinase

1990 • 210 citations

Subcellular Localization and Characterization of Neuronal Nitric Oxide Synthase

1994 • 148 citations

Blockade of nitric oxide formation by mitigates ischemic brain edema and subsequent cerebral infarction in rats

1992 • 142 citations

Neuroprotective effects of NG-nitro-L-arginine in focal stroke in the 7-day old rat

1992 • 133 citations

Effect of nitric oxide synthase inhibition on cerebral blood flow and injury volume during focal ischemia in cats.

1993 • 127 citations

Phosphorylation of nitric oxide synthase by protein kinase A

1991 • 114 citations

Purification and characterization of two forms of cyclic GMP-dependent protein kinase from bovine aorta.

1988 • 86 citations

Characterization of particulate cyclic nucleotide phosphodiesterases from bovine brain: purification of a distinct cGMP-stimulated isoenzyme

1990 • 46 citations

Purification and partial characterization of membrane-associated type II (cGMP-activatable) cyclic nucleotide phosphodiesterase from rabbit brain

1988 • 45 citations