Mechanical deformation of vessel wall and shear stress determine the basal release of endothelium-derived relaxing factor in the intact rabbit coronary vascular bed.

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

1988 • 1,417 citations

Flow-induced release of endothelium-derived relaxing factor

1986 • 1,379 citations

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.

1990 • 1,209 citations

Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis.

1991 • 1,010 citations

Crucial role of endothelium in the vasodilator response to increased flow in vivo.

1986 • 991 citations

Control of coronary vascular tone by nitric oxide.

1990 • 713 citations

Large coronary arteries in humans are responsive to changing blood flow: An endothelium-dependent mechanism that fails in patients with atherosclerosis

1990 • 302 citations

Endothelin-1 and Endothelin-3 Release EDRF from Isolated Perfused Arterial Vessels of the Rat and Rabbit

1989 • 302 citations

Nitric oxide synthesized from L‐arginine regulates vascular tone in the coronary circulation of the rabbit

1989 • 279 citations

Flow stimulates endothelial cells to release a nitrovasodilator that is potentiated by reduced thiol

1990 • 260 citations

Reactive dilation of large coronary arteries in conscious dogs.

1984 • 206 citations

Nitric oxide release from the isolated guinea pig heart

1988 • 153 citations

EDRF increases cyclic GMP in platelets during passage through the coronary vascular bed.

1989 • 98 citations

Endothelium-Dependent Flow-Induced Dilation of Canine Femoral and Saphenous Arteries

1986 • 90 citations

Effects of endothelin on coronary flow, mechanical performance, oxygen uptake, and formation of purines and on outflow of prostacyclin in the isolated rabbit heart.

1990 • 76 citations

Rhythmic smooth muscle activity in hamster aortas is mediated by continuous release of NO from the endothelium

1991 • 63 citations

[29] Guanylate cyclase in human platelets

1974 • 48 citations

Functional state of the endothelium determines the response to endothelin in the coronary circulation

1990 • 30 citations

[34] Purification of heme-containing soluble guanylyl cyclase

1991 • 23 citations

Release of endothelial mediators and sympathetic transmitters at different coronary flow rates in rabbit hearts.

1991 • 17 citations

Dilatation of conduit coronary artery induced by high blood flow.

1983 • 15 citations

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