Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Endothelium‐derived relaxing and contracting factors

1989 • 2,017 citations

Neuronal NADPH diaphorase is a nitric oxide synthase.

1991 • 1,917 citations

Endothelium‐derived nitric oxide: actions and properties

1989 • 686 citations

Endothelium-derived relaxing factor

1988 • 686 citations

Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.

1991 • 599 citations

N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.

1991 • 572 citations

Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages

1989 • 571 citations

Purification of a Ca²⁺/calmodulin‐dependent nitric oxide synthase from porcine cerebellum

1990 • 433 citations

Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.

1991 • 386 citations

The Isolation and Characterization of Dihydropteridine Reductase from Sheep Liver

1972 • 256 citations

Inhibition of Dihydrofolic Reductase by Aminopterin and Amethopterin.

1958 • 217 citations

Studies on the Structure of the Primary Oxidation Product Formed from Tetrahydropteridines during Phenylalanine Hydroxylation

1964 • 214 citations

The role of ascorbate in the prolyl hydroxylase reaction

1978 • 211 citations

Kinetic characteristics of nitric oxide synthase from rat brain

1990 • 210 citations

FAD and GSH participate in macrophage synthesis of nitric oxide

1990 • 182 citations

Metabolism of the Phenylalanine Hydroxylation Cofactor

1967 • 179 citations

Further Studies on Dihydrofolic Reductase

1963 • 138 citations

Prolyl 4-hydroxylase activity in relation to the oxidation state of enzyme-bound iron

1982 • 107 citations

The auto‐oxidation of tetrahydrobiopterin

1988 • 90 citations

Characterization of the dihydropterin reductase activity of pig liver methylenetetrahydrofolate reductase.

1980 • 73 citations

Stoichiometric reduction of phenylalanine hydroxylase by its cofactor: a requirement for enzymatic activity

1984 • 67 citations

Peroxidase catalysed aerobic degradation of 5,6,7,8‐tetrahydrobiopterin at physiological pH

1983 • 53 citations

Isolation and characterization of tetrahydropterin oxidation products generated in the tyrosine 3-monooxygenase (tyrosine hydroxylase) reaction

1987 • 50 citations

Mechanism of Oxidation of Tetrahydropterins

1972 • 43 citations

[1] Phenylalanine 4-monooxygenase from rat liver

1987 • 42 citations

Regulation of the activity of hepatic phenylalanine hydroxylase

1986 • 27 citations

A New Enzyme, NADPH-Dihydropteridine Reductase in Bovine Liver

1977 • 22 citations

Stabilizing factor(s) of nitric oxide (NO) synthetase

1990 • 10 citations