Role of nuclear factor kappa B in neuropathological mechanisms

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

1995 • 2,386 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

Inhibition of NF-κB by Sodium Salicylate and Aspirin

1994 • 1,743 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

Inhibition of Nuclear Translocation of Transcription Factor NF-κB by a Synthetic Peptide Containing a Cell Membrane-permeable Motif and Nuclear Localization Sequence

1995 • 923 citations

Calcium: still center-stage in hypoxic-ischemic neuronal death

1995 • 921 citations

Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

1989 • 821 citations

Tumor necrosis factor-alpha expression in ischemic neurons.

1994 • 793 citations

Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation

1996 • 760 citations

Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyrosine-15

1995 • 658 citations

NF-κB is activated and promotes cell death in focal cerebral ischemia

1999 • 648 citations

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

1995 • 632 citations

Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease

1997 • 611 citations

Activation of NF-?B protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration

1997 • 572 citations

Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

1992 • 547 citations

P53, cell cycle control and apoptosis: Implications for cancer

1995 • 467 citations

The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity.

1992 • 446 citations

Constitutive NF-kB Activity in Neurons

1994 • 400 citations

Evidence for Involvement of NF-κB in the Transcriptional Control of COX-2 Gene Expression by IL-1β

1997 • 390 citations

TNF-α Pretreatment Induces Protective Effects against Focal Cerebral Ischemia in Mice

1997 • 346 citations

Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκB-dependent mechanism

1998 • 339 citations

NMDA receptor-dependent excitotoxicity: the role of intracellular Ca2+ release

1995 • 319 citations

Stimulation of ionotropic glutamate receptors activates transcription factor NF-kappa B in primary neurons.

1995 • 312 citations

Constitutive NF-kappa B activity in neurons.

1994 • 304 citations

Nuclear Factor-κB Plays an Essential Role in the Late Phase of Ischemic Preconditioning in Conscious Rabbits

1999 • 302 citations

Calcium: still center-stage in hypoxic-ischemic neuronal death

1995 • 280 citations

Inhibition of NF-κB potentiates amyloid β-mediated neuronal apoptosis

1999 • 280 citations

Mechanism of action of antiinflammatory drugs.

1998 • 266 citations

Aspirin Inhibits Nuclear Factor–κB Mobilization and Monocyte Adhesion in Stimulated Human Endothelial Cells

1995 • 260 citations

The Transcription Factor NF‐κB Mediates Increases in Calcium Currents and Decreases in NMDA‐ and AMPA/Kainate‐Induced Currents Induced by Tumor Necrosis Factor‐α in Hippocampal Neurons

1998 • 252 citations

c-Myc and apoptosis

1995 • 251 citations

Lack of the p50 subunit of nuclear factor-kappaB increases the vulnerability of hippocampal neurons to excitotoxic injury.

1999 • 241 citations

Interleukin-1 receptor antagonist decreases the number of necrotic neurons in rats with middle cerebral artery occlusion.

1995 • 238 citations

Nuclear factor kappaB nuclear translocation upregulates c-Myc and p53 expression during NMDA receptor-mediated apoptosis in rat striatum.

1999 • 234 citations

Global Ischemia Activates Nuclear Factor-κB in Forebrain Neurons of Rats

1997 • 219 citations

Nuclear Factor κB Nuclear Translocation Upregulates c-Myc and p53 Expression during NMDA Receptor-Mediated Apoptosis in Rat Striatum

1999 • 206 citations

Lack of the p50 Subunit of Nuclear Factor-κB Increases the Vulnerability of Hippocampal Neurons to Excitotoxic Injury

1999 • 202 citations

Transcription Factor Nuclear Factor-Kappa B is Activated in Neurons after Focal Cerebral Ischemia

2000 • 196 citations

Induction of neuroprotective κB-dependent transcription by secreted forms of the Alzheimer's β-amyloid precursor

1996 • 192 citations

Inhibition of Tumor Necrosis Factor and Amelioration of Brain Infarction in Mice

1997 • 190 citations

The NF-κB/Rel family of proteins mediates Aβ-induced neurotoxicity and glial activation

1998 • 187 citations

p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats.

1994 • 183 citations

Inhibition of nuclear factor kappa B (NF?B) activity induces nerve growth factor-resistant apoptosis in PC12 cells

1997 • 177 citations

Prolonged Activation of NF-κB Following Traumatic Brain Injury in Rats

1999 • 167 citations

Nuclear Factor-κB Contributes to Excitotoxin-Induced Apoptosis in Rat Striatum

1998 • 167 citations

Neuroprotective effects of TNF binding protein in focal cerebral ischemia

1997 • 153 citations

Alteration of Transcription Factor Binding Activities in the Ischemic Rat-Brain

1995 • 153 citations

Nuclear translocation of NF-κB in cholinergic neurons of patients with Alzheimerʼs disease

1997 • 151 citations

Seizure Activity Results in a Rapid Induction of Nuclear Factor‐κB in Adult but Not Juvenile Rat Limbic Structures

1996 • 134 citations

Activation of nuclear factor-κB in the rat brain after transient focal ischemia

1999 • 126 citations

Potential involvement of the transcription factor NF-κB in neurological disorders

1993 • 123 citations

Global cerebral ischemia activates nuclear factor-κB prior to evidence of DNA fragmentation

1997 • 121 citations

p53: A Cell Cycle Regulator Activated by DNA Damage

1995 • 121 citations

p53 Expression in brain after middle cerebral artery occlusion in the rat

1992 • 120 citations

Sodium Salicylate and 17β‐Estradiol Attenuate Nuclear Transcription Factor NF‐κB Translocation in Cultured Rat Astroglial Cultures Following Exposure to Amyloid Aβ_1‐40 and Lipoplysaccharides

1999 • 114 citations

Drug-Induced Neuroprotection From Global Ischemia Is Associated With Prevention of Persistent but Not Transient Activation of Nuclear Factor-κB in Rats

1998 • 113 citations

Alteration of transcription factors NF-κB and STAT1 in Alzheimer's disease brains

1997 • 112 citations

S100β Induction of the Proinflammatory Cytokine Interleukin‐6 in Neurons

2000 • 111 citations

Neuroprotection by dehydroepiandrosteronesulfate

1998 • 109 citations

Mechanisms that Result in Damage During and Following Cerebral Ischemia

1997 • 105 citations

Involvement of interleukin-1 and lipocortin-1 in ischaemic brain damage.

1993 • 90 citations

Enhancement of immunoreactivity for NF-κB in human cerebral infarctions

1996 • 90 citations

Nuclear factor-κB activation during cerebral reperfusion: effect of attenuation with N-acetylcysteine treatment

1998 • 86 citations

Bcl-Xshort is elevated following severe global ischemia in rat brains

1997 • 83 citations

Tissue-selective inhibition of prostaglandin synthesis in rat by tepoxalin: Anti-inflammatory without gastropathy?

1993 • 74 citations

Induction of NF-kB-like transcription factors in brain areas susceptible to kainate toxicity

1996 • 74 citations

Involvement of glutamate receptors, lipases, and phospholipases in long‐term potentiation and neurodegeneration

1994 • 73 citations

Ascorbate Transport and Intracellular Concentration in Cerebral Astrocytes

1995 • 71 citations

4‐trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2‐hydroxy‐4‐trifluoromethylbenzoic acid, are potent inhibitors of nuclear factor κB activation

1999 • 69 citations

NF‐kB immunoreactivity is observed in association with βA4 diffuse plaques in patients with Alzheimer’s disease

1998 • 67 citations

STAT3 and NFκB Activation Precedes Glial Reactivity in the Excitotoxically Injured Young Cortex but not in the Corresponding Distal Thalamic Nuclei

2000 • 67 citations

Loss of NF-κB Activity during Cerebral Ischemia and TNF Cytotoxicity

1999 • 59 citations

Age-associated alterations in hippocampal and basal forebrain nuclear factor kappa B activity

1997 • 57 citations

Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid.

1999 • 50 citations

Neuroprotection achieved with a novel proteasome inhibitor which blocks NF-κB activation

2000 • 48 citations

Kainate receptors activate NF-κB via MAP kinase in striatal neurones

2000 • 47 citations

Kainic acid-induced activation of nuclear factor-κB in rat hippocampus

1999 • 47 citations

Induction of ischemic tolerance in rat cortical neurons by 3-nitropropionic acid: chemical preconditioning

1999 • 45 citations

Free radical scavenger OPC-14117 attenuates quinolinic acid-induced NF-κB activation and apoptosis in rat striatum

1999 • 43 citations

Co-stimulation of cyclic-AMP-linked metabotropic glutamate receptors in rat striatum attenuates excitotoxin-induced nuclear factor-κB activation and apoptosis

1999 • 35 citations

Mechanism of amyloid β protein induced neuronal cell death: current concepts and future perspectives

1997 • 33 citations

Nuclear factor kappa B-mediated kainate neurotoxicity in the rat and hamster hippocampus

1999 • 32 citations

Constitutive NF-κB activity is modulated via neuron-astroglia interaction

2000 • 31 citations

The non-steroidal anti-inflammatory drug tepoxalin inhibits interleukin-6 and alphal-anti-chymotrypsin synthesis in astrocytes by preventing degradation of IκB-alpha

1999 • 29 citations

Stat3 and NFκB glial expression after excitotoxic damage to the postnatal brain

1998 • 24 citations

Inhibition of the activity of a neuronal kappaB-binding factor by glutamate.

1999 • 22 citations

Inhibition of the Activity of a Neuronal κB‐Binding Factor by Glutamate

1999 • 19 citations

Participation of Gene Expression in the Protection against Amyloid β‐Peptide Toxicity by the β‐Amyloid Precursor Proteina

1996 • 19 citations