S100β Induction of the Proinflammatory Cytokine Interleukin‐6 in Neurons

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

1989 • 1,752 citations

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.

1990 • 1,377 citations

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.

1993 • 955 citations

Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta.

1993 • 789 citations

Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients

1995 • 758 citations

Glial‐Neuronal Interactions in Alzheimer's Disease: The Potential Role of a ‘Cytokine Cycle’ in Disease Progression

1998 • 695 citations

On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases

1989 • 692 citations

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

1995 • 632 citations

Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease

1997 • 611 citations

Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E

1997 • 601 citations

In vivo transfection of cis element “decoy” against nuclear factor- κB binding site prevents myocardial infarction

1997 • 601 citations

Interleukin‐6 and α‐2‐macroglobulin indicate an acute‐phase state in Alzheimer's disease cortices

1991 • 484 citations

Glial cytokines in Alzheimer's disease: Review and pathogenic implications

1995 • 412 citations

Activation of Interleukin-6 Gene Expression through the NF-κB Transcription Factor

1990 • 379 citations

Purification and characterization of a neurite extension factor from bovine brain.

1985 • 378 citations

Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκB-dependent mechanism

1998 • 339 citations

S100β Induces Neuronal Cell Death Through Nitric Oxide Release from Astrocytes

1997 • 327 citations

Induction and regulation of interleukin-6 gene expression in rat astrocytes

1990 • 314 citations

Induction of interleukin-6 in axotomized sensory neurons

1995 • 273 citations

Neurite extension and neuronal survival activities of recombinant S100 beta proteins that differ in the content and position of cysteine residues.

1989 • 269 citations

Interleukin-6 Induction by Tumor Necrosis Factor and Interleukin-1 in Human Fibroblasts Involves Activation of a Nuclear Factor Binding to a κΒ-Like Sequence

1990 • 269 citations

Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated ‘acute phase response’ in the brain?

1991 • 267 citations

Increased S100β neurotrophic activity in Alzheimer's disease temporal lobe

1992 • 214 citations

Correlation of Astrocytic S100β Expression with Dystrophic Neurites in Amyloid Plaques of Alzheimerʼs Disease

1996 • 210 citations

Glial-Neuronal Interactions in Alzheimer Disease

1997 • 207 citations

Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients

1995 • 204 citations

S100 beta stimulates calcium fluxes in glial and neuronal cells.

1992 • 199 citations

Localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain

1992 • 195 citations

S100β protein expression in Alzheimer disease: Potential role in the pathogenesis of neuritic plaques

1994 • 179 citations

Interleukin-6 mRNA expression by cortical neurons in culture: Evidence for neuronal sources of interleukin-6 production in the brain

1995 • 160 citations

α1-Antichymotrypsin is associated solely with amyloid deposits containing the β-protein. Amyloid and cell localization of α1-antichymotrypsin

1990 • 153 citations

Cytokine regulation of interleukin-6 gene expression in astrocytes involves activation of an NF-κ B-like nuclear protein

1992 • 147 citations

Purification and NH2-terminal sequence of a plasmacytoma growth factor derived from the murine macrophage cell line P388D1.

1987 • 145 citations

Identification of interleukin-6 (IL-6)-expressing neurons in the cerebellum and hippocampus of normal adult rats

1994 • 128 citations

Disulfide-linked S100β dimers and signal transduction

1992 • 116 citations

Alteration of transcription factors NF-κB and STAT1 in Alzheimer's disease brains

1997 • 112 citations

Neuroprotection by dehydroepiandrosteronesulfate

1998 • 109 citations

S100β Increases Levels of β‐Amyloid Precursor Protein and Its Encoding mRNA in Rat Neuronal Cultures

1998 • 106 citations

Alpha 2‐macroglobulin synthesis in interleukin‐6‐stimulated human neuronal (SH‐SY5Y neuroblastoma) cells Potential significance for the processing of Alzheimer β‐amyloid precursor protein

1991 • 93 citations

The NF-kappaB transcription factor in oncogenesis.

1996 • 75 citations

Interleukin 6 is autoregulated by transcriptional mechanisms in cultures of rat osteoblastic cells.

1997 • 64 citations

Characterization of a neuronal κB-binding factor distinct from NF-κB

1999 • 47 citations

Mechanisms of Action of the S100 Family of Calcium Modulated Proteins

1988 • 32 citations

Sequence-specific interaction of α β-anomeric doublestranded DNA with the p50 subunit of NFxB: application to the decoy approach

1994 • 30 citations

Inhibition of the activity of a neuronal kappaB-binding factor by glutamate.

1999 • 22 citations

Inhibition of the Activity of a Neuronal κB‐Binding Factor by Glutamate

1999 • 19 citations