The molecular mechanisms of cardiovascular and renal regulation by endothelin peptides.

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

1988 • 1,417 citations

Receptor-effector coupling by G proteins

1990 • 1,117 citations

Peptide growth factors are multifunctional

1988 • 835 citations

Roles of G protein subunits in transmembrane signalling

1988 • 794 citations

Endothelin stimulates c‐fos and c‐myc expression and proliferation of vascular smooth muscle cells

1988 • 737 citations

A family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 636 citations

Post-Translational Proteolysis in Polypeptide Hormone Biosynthesis

1982 • 590 citations

Endothelin stimulates phospholipase C, Na+/H+ exchange, c-fos expression, and mitogenesis in rat mesangial cells.

1989 • 561 citations

Protein kinase C in the regulation of smooth muscle contraction

1987 • 543 citations

Hemodynamic shear stress stimulates endothelin production by cultured endothelial cells

1989 • 496 citations

A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts

1989 • 485 citations

Integrated cardiac, renal, and endocrine actions of endothelin.

1989 • 481 citations

Endothelin in brain: receptors, mitogenesis, and biosynthesis in glial cells.

1990 • 480 citations

Endothelins, peptides with potent vasoactive properties, are produced by human macrophages.

1990 • 462 citations

Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries. A new mechanism of vasospasm?

1990 • 446 citations

The Human Preproendothelin-1 Gene

1989 • 441 citations

Transforming growth factor-β stimulates the expression of endothelin mRNA by vascular endothelial cells

1989 • 420 citations

Inositol trisphosphate-induced calcium release and contraction in vascular smooth muscle.

1985 • 417 citations

Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways.

1989 • 413 citations

Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium‐derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin

1988 • 400 citations

Cellular signaling by peptides of the endothelin gene family

1990 • 391 citations

Role of endothelin in cyclosporine-induced glomerular dysfunction

1990 • 368 citations

Endothelin, a novel endothelium-derived peptide

1989 • 365 citations

Sarafotoxin, a Novel Vasoconstrictor Peptide: Phosphoinositide Hydrolysis in Rat Heart and Brain

1988 • 362 citations

Peptide growth factors and inflammation, tissue repair, and cancer.

1986 • 360 citations

Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor.

1991 • 360 citations

Regulation of Smooth Muscle Contractile Elements by Second Messengers

1989 • 357 citations

Endothelin: visualization of mRNAs by in situ hybridization provides evidence for local action.

1989 • 354 citations

Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle.

1989 • 353 citations

Glomerular actions of endothelin in vivo.

1989 • 351 citations

Endothelin 1, an endothelium-derived peptide, is expressed in neurons of the human spinal cord and dorsal root ganglia.

1989 • 349 citations

Positive inotropic action of novel vasoconstrictor peptide endothelin on guinea pig atria

1988 • 347 citations

Abundance of endothelin-3 in rat intestine, pituitary gland and brain

1989 • 346 citations

Endothelin action on vascular smooth muscle involves inositol trisphosphate and calcium mobilization

1989 • 346 citations

Women with Preeclampsia have Higher Plasma Endothelin Levels than Women with Normal Pregnancies

1990 • 344 citations

Immunoreactive endothelin in human plasma: Marked elevations in patients in cardiogenic shock

1989 • 330 citations

Growth factor activity of endothelin on vascular smooth muscle

1990 • 325 citations

Molecular mechanism of action of the vasoconstrictor peptide endothelin

1988 • 317 citations

Endothelin: A Novel Peptide in the Posterior Pituitary System

1990 • 313 citations

Inflammation and Repair

1990 • 310 citations

Endothelin, a novel vasoconstrictor peptide, as potent brochoconstrictor

1988 • 304 citations

Interaction between endothelin-1 and endothelium-derived relaxing factor in human arteries and veins.

1990 • 297 citations

Increased endothelin in experimental heart failure.

1990 • 288 citations

Cardiovascular, renal, and endocrine responses to intravenous endothelin in conscious dogs

1988 • 279 citations

Stimulation of endothelin mRNA and secretion in rat vascular smooth muscle cells: a novel autocrine function.

1990 • 271 citations

Endotoxin stimulates endothelin-release in vivo and in vitro as determined by radioimmunoassay

1989 • 265 citations

A Novel Peptide, Vasoactive Intestinal Contractor, of a New (Endothelin) Peptide Family

1989 • 260 citations

Interleukin 1 increases the production of endothelin-1 by cultured endothelial cells

1990 • 259 citations

Presence of immunoreactive endothelin in human plasma

1989 • 258 citations

The hydrolysis of endothelins by neutral endopeptidase 24.11 (enkephalinase).

1990 • 247 citations

Increased plasma level of endothelin-1 and coronary spasm induction in patients with vasospastic angina pectoris.

1991 • 243 citations

Excitation-contraction coupling and the ultrastructure of smooth muscle.

1985 • 242 citations

Endothelin stimulates phospholipase C in cultured vascular smooth muscle cells

1988 • 241 citations

Endothelin is a positive inotropic agent in human and rat heart in, vitro

1989 • 235 citations

Endothelin: a potent renal and systemic vasoconstrictor peptide

1989 • 232 citations

Expression of the potent vasoconstrictor endothelin in the human central nervous system.

1990 • 228 citations

Elevated Plasma Endothelin-1 Concentrations Are Associated with the Severity of Illness in Patients with Sepsis

1991 • 227 citations

cDNA cloning, sequence analysis and tissue distribution of rat preproendothelin-1 mRNA

1991 • 226 citations

Effect of endothelin-1 in man.

1990 • 225 citations

A role for neuropeptides in the control of cell proliferation

1987 • 225 citations

Structure-activity relationships of endothelin: Importance of the C-terminal moiety

1988 • 220 citations

ENDOTHELIN: AN IMPORTANT FACTOR IN ACUTE RENAL FAILURE?

1988 • 214 citations

Rapid release of endothelin and ATP from isolated aortic endothelial cells exposed to increased flow

1990 • 211 citations

Inducibleendothelin mRNA expression and peptide secretion in cultured human vascular smooth muscle cells

1990 • 210 citations

Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptide

1988 • 203 citations

Enhanced secretion of endothelin‐1 by elevated glucose levels from cultured bovine aortic endothelial cells

1990 • 196 citations

The biosynthesis of endothelin-1 by human polymorphonuclear leukocytes

1991 • 194 citations

Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide-binding regulatory protein in vascular smooth muscle cells.

1990 • 187 citations

Thrombin enhances the release of endothelin from cultured porcine aortic endothelial cells

1989 • 185 citations

Structural Organization and Chromosomal Assignment of the Gene Encoding Endothelin

1989 • 178 citations

Endothelin mediates the renal vasoconstriction induced by cyclosporine in the rat.

1990 • 176 citations

Pathophysiological role of endothelin in acute renal failure

1990 • 173 citations

Endothelin Stimulation of Cytosolic Calcium and Gonadotropin Secretion in Anterior Pituitary Cells

1990 • 172 citations

cDNA cloning and chromosomal assignment of the gene encoding endothelin 3

1989 • 167 citations

Stimulation of Phosphatidylinositol Hydrolysis, Diacylglycerol Release, and Gene Expression in Response to Endothelin, a Potent New Agonist for Fibroblasts and Smooth Muscle Cells

1989 • 166 citations

Endothelin enhances the contractile responsiveness of adult rat ventricular myocytes to calcium by a pertussis toxin-sensitive pathway.

1990 • 165 citations

Phosphoramidon blocks the pressor activity of porcine big endothelin-1-(1-39) in vivo and conversion of big endothelin-1-(1-39) to endothelin-1-(1-21) in vitro.

1991 • 165 citations

Production of endothelin in human cancer cell lines.

1990 • 165 citations

Activation of phospholipase A2 by endothelin in cultured vascular smooth muscle cells

1989 • 164 citations

Endothelin-1 mRNA is widely expressed in porcine and human tissues.

1990 • 164 citations

Endothelin, a potent peptide agonist in the liver.

1990 • 161 citations

Endothelin-1 stimulates contraction of rat glomerular mesangial cells and potentiates beta-adrenergic-mediated cyclic adenosine monophosphate accumulation.

1990 • 161 citations

Endothelin binding to cultured calf adrenal zona glomerulosa cells and stimulation of aldosterone secretion.

1989 • 160 citations

Hypertension Associated with Endothelin-Secreting Malignant Hemangioendothelioma

1991 • 158 citations

Phosphoramidon, a metalloproteinase inhibitor, suppresses the hypertensive effect of big endothelin-1

1990 • 158 citations

Increased renal endothelin production in rats with reduced renal mass

1991 • 154 citations

Endothelin action: Inhibition by a protein kinase C inhibitor and involvement of phosphoinositols

1989 • 154 citations

Similarities in mode and sites of action of sarafotoxins and endothelins

1989 • 152 citations

Endothelin stimulates phosphatidylinositol hydrolysis and DNA synthesis in brain capillary endothelial cells

1990 • 149 citations

The Fate of Radioiodinated Endothelin-1 and Endothelin-3 in the Rat

1989 • 149 citations

Atrial natriuretic peptide, nitroglycerine, and nitroprusside reduce basal and stimulated endothelin production from cultured endothelial cells

1990 • 148 citations

Inhibition of biological actions of big endothelin-1 by phosphoramidon

1990 • 146 citations

Endothelin in Human Brain and Pituitary Gland: Presence of Immunoreactive Endothelin, Endothelin Messenger Ribonucleic Acid, and Endothelin Receptors

1991 • 143 citations

Endothelin and Ca++ agonist bay K 8644: Different vasoconstrictive properties

1988 • 136 citations

Endothelin is a potent long-lasting vasoconstrictor in men

1989 • 134 citations

Endothelin: A New Cardiovascular Regulatory Peptide

1990 • 133 citations

Conversion of big endothelin-1 by membrane-bound matalloendopeptidase in cultured bovine endothelial cells

1990 • 132 citations

Constitutive expression of endothelin gene in cultured human mesangial cells and its modulation by transforming growth factor-beta, thrombin, and a thromboxane A2 analogue.

1991 • 124 citations

Cytokine-induced release of endothelin-1 from porcine renal epithelial cell line

1990 • 122 citations

Endothelin in the gastrointestinal tract

1990 • 121 citations

cDNA cloning and chromosomal assignment of the endothelin 2 gene: Vasoactive intestinal contractor peptide is rat endothelin 2

1991 • 120 citations

Endothelins are more sensitive than sarafotoxins to neutral endopeptidase: possible physiological significance.

1990 • 118 citations

Endothelin-1 induces vasoconstriction through two functionally distinct pathways in porcine coronary artery: Contribution of phosphoinositide turnover

1989 • 116 citations

Reduction of local cerebral blood flow to pathological levels by endothelin-1 applied to the middle cerebral artery in the rat

1990 • 115 citations

Endothelin augments unitary calcium channel currents on the smooth muscle cell membrane of guinea‐pig portal vein.

1990 • 113 citations

Inhibition of adrenergic neuroeffector transmission by endothelin in the guinea‐pig femoral artery

1988 • 112 citations

Conversion of big endothelin‐1 to endothelin‐1 by two types of metalloproteinases derived from porcine aortic endothelial cells

1990 • 112 citations

Astrocytes Are Target Cells for Endothelins and Sarafotoxin

1990 • 111 citations

Endothelin action in rat liver. Receptors, free Ca2+ oscillations, and activation of glycogenolysis.

1991 • 110 citations

Direct visualization of effects of endothelin on the renal microvasculature

1990 • 110 citations

Renal microvascular effects of endothelin

1990 • 110 citations

Production of endothelin-1 by rat cultured mesangial cells

1990 • 108 citations

The activity of peptides of the endothelin family in various mammalian smooth muscle preparations

1989 • 108 citations

Localization of endothelin‐like immunoreactivity in airway epithelium of rats and mice

1990 • 104 citations

Potent contractile effect of endothelin in isolated guinea-pig airways

1989 • 104 citations

Regulated expression of endothelin 1 in glomerular capillary endothelial cells

1991 • 104 citations

The inotropic effect of endothelin‐1 on rat atria involves hydrolysis of phosphatidylinositol

1989 • 102 citations

Upregulation of renal endothelin receptors in rats with cyclosporine A-induced nephrotoxicity

1990 • 100 citations

The mucoid cap over superficial gastric damage in the rat

1990 • 96 citations

Immunocytochemical localization of endothelin in cultured bovine endothelial cells

1990 • 94 citations

Endothelin - a new family of endothelium-derived peptides with widespread biological properties

1989 • 93 citations

Influence of endothelin on human coronary arteries and localization of its binding sites

1989 • 93 citations

Processing of pro-hormone precursor proteins

1989 • 89 citations

Lethal ischemia due to intracoronary endothelin in pigs

1989 • 89 citations

Endothelin in Renal Failure

1990 • 88 citations

Potent cyclo-oxygenase-mediated bronchoconstrictor effects of endothelin in the guinea-pig in vivo

1988 • 88 citations

Endothelin stimulates atrial natriuretic peptide (ANP) release from rat atria

1988 • 87 citations

Endothelin mobilizes Ca2+ from a caffeine- and ryanodine-insensitive intracellular pool in rat atrial cells.

1990 • 87 citations

Phorbol ester dissociates endothelin-stimulated phosphoinositide hydrolysis and arachidonic acid release in vascular smooth muscle cells

1989 • 86 citations

Endothelin-induced CA-independent contraction of the porcine coronary artery

1989 • 86 citations

Endothelins activate Na+/H+ exchange in brain capillary endothelial cells via a high affinity endothelin-3 receptor that is not coupled to phospholipase C.

1991 • 86 citations

Direct effects of endothelin in the rat kidney

1990 • 85 citations

Cellular mechanisms of endothelin in rabbit aorta.

1989 • 85 citations

Endothelin: A potent vasoconstrictor associated with coronary vasospasm

1989 • 83 citations

Pharmacological modulation of the bronchopulmonary action of the vasoactive peptide, endothelin, administered by aerosol in the guinea-pig

1989 • 83 citations

Characterization of Contractile Responses to Endothelin in Human Cerebral Arteries: Implications for Cerebral Vasospasm

1990 • 80 citations

Specific receptor for endothelin in cultured rat cardiocytes

1989 • 78 citations

Endothelin-3 inhibits prolactin and stimulates LH, FSH and TSH secretion from pituitary cell culture

1991 • 78 citations

Endothelin. Pathways of transmembrane signaling.

1990 • 78 citations

Phosphoramidon inhibits the intracellular conversion of big endothelin-1 to endothelin-1 in cultured endothelial cells

1991 • 78 citations

Activation of multiple signal transduction pathways by endothelin in cultured human vascular smooth muscle cells

1990 • 77 citations

Endothelin stimulates PDGF secretion in cultured human mesangial cells

1990 • 76 citations

Arginine vasopressin stimulates human mesangial cell production of endothelin.

1991 • 75 citations

Chronic hypertension produced by infusion of endothelin in rats.

1990 • 75 citations

Modulation of the [Ca2+] sensitivity of myosin phosphorylation in intact swine arterial smooth muscle.

1990 • 73 citations

Role of thromboxane A2/prostaglandin H2 receptor in the vasoconstrictor response of rat aorta to endothelin.

1990 • 73 citations

The structural characterization of beta-endorphin and related peptide hormones and neurotransmitters.

1986 • 72 citations

The Evolution of Peptide Hormones

1982 • 71 citations

Endothelin receptor-coupling mechanisms in vascular smooth muscle: a role for protein kinase C.

1990 • 69 citations

Stimulation of the hydrolysis of phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine by endothelin, a complete mitogen for Rat-1 fibroblasts

1990 • 68 citations

Characterization of endothelin 1 receptor and signal transduction mechanisms in rat medullary interstitial cells

1991 • 68 citations

Characterization of endothelin converting enzyme activities in soluble fraction of bovine cultured endothelial cells

1990 • 67 citations

Endothelin increases single‐channel calcium currents in coronary arterial smooth muscle cells

1989 • 67 citations

Detection of endothelin immunoreactivity and mRNA in pulmonary tumours

1990 • 66 citations

Endothelins: a family of regulatory peptides. State-of-the-art lecture.

1991 • 65 citations

High and low affinity binding sites for endothelin on cultured rat glomerular mesangial cells

1989 • 65 citations

Endothelin in human plasma and culture medium of aortic endothelial cells—Detection and characterization with radioimmunoassay using monoclonal antibody

1989 • 65 citations

Functional endothelin/sarafotoxin receptors in rat heart myocytes: Structure-activity relationships and receptor subtypes

1989 • 64 citations

Endothelin-1 gene expression and regulation of endothelin mRNA and protein biosynthesis in avascular human amnion. Potential source of amniotic fluid endothelin.

1991 • 64 citations

Endothelin Enhances Adrenocorticotropin-Stimulated Aldosterone Release from Cultured Bovine Adrenal Cells*

1990 • 63 citations

Endothelin: a potential modulator of cerebral vasospasm

1990 • 63 citations

Ca2+ signaling by distinct endothelin peptides in glomerular mesangial cells

1991 • 63 citations

Endothelin as an autocrine factor in the regulation of parathyroid cells.

1991 • 62 citations

Identification of endothelin receptors in various regions of rat brain

1990 • 60 citations

Endothelin-induced increases in vascular smooth muscle Ca2+ do not depend on dihydropyridine-sensitive Ca2+ channels.

1989 • 59 citations

Expression and regulation of endothelin precursor mRNA m avascular human amnion

1990 • 58 citations

Autocrine effect of endothelin on DNA synthesis in human vascular endothelial cells

1990 • 57 citations

Release of Substance P from Rat Hypothalamus and Pituitary by Endothelin

1990 • 57 citations

Immunoreactive endothelin concentrations in maternal and fetal blood

1990 • 57 citations

Endothelin and a Ca²⁺ ionophore raise cyclic GMP levels in a neuronal cell line via formation of nitric oxide

1990 • 55 citations

Renal vasoconstriction by the endothelial cell-derived peptide endothelin in spontaneously hypertensive rats.

1989 • 55 citations

Plasma concentrations of endothelin in patients with abnormal vascular reactivity

1990 • 55 citations

Detection of immunoreactive endothelin in plasma of hemodialysis patients

1989 • 53 citations

Comparative studies of phosphoinositide hydrolysis induced by endothelin-related peptides in cultured cerebellar astrocytes, C6-glioma and cerebellar granule cells

1990 • 52 citations

Plasma concentrations of endothelin in man: arterio‐venous differences and release during venous stasis

1990 • 52 citations

Specific expression of human endothelin‐2 (ET‐2) gene in a renal adenocarcinoma cell line

1990 • 51 citations

Endothelin stimulates degradation of phospholipids in isolated rat hearts

1991 • 51 citations

Calcium dependence of phenylephrine-, endothelin-, and potassium chloride-stimulated atrial natriuretic factor secretion from long term primary neonatal rat atrial cardiocytes.

1990 • 51 citations

Endothelin-1 stimulates DNA synthesis and anchorage-independent growth of Rat-1 fibroblasts through a protein kinase C-dependent mechanism.

1990 • 50 citations

Endothelin-1 and platelet activating factor stimulate thromboxane A2 biosynthesis in rat vascular smooth muscle cells

1990 • 49 citations

Nickel inhibits endothelin-induced contractions of vascular smooth muscle

1990 • 48 citations

Endothelin-3 stimulates production of endothelium-derived nitric oxide via phosphoinositide breakdown

1991 • 47 citations

Effects of indomethacin on the regional haemodynamic responses to low doses of endothelins and sarafotoxin

1990 • 46 citations

Renal actions of endothelin: interaction with prostacyclin

1990 • 45 citations

Endothelin-1 contracts isolated vessels independently of dihydropyridine-sensitive Ca2+ channel activation

1989 • 43 citations

Evidence for receptor-mediated bivalent-cation entry in A10 vascular smooth-muscle cells

1990 • 42 citations

Phorbol ester promotes a sustained down-regulation of endothelin receptors and cellular responses to endothelin in human vascular smooth muscle cells

1990 • 41 citations

Endothelin induces thromboxane release and contraction of isolated guinea-pig airways

1990 • 40 citations

Endothelin-1 increases arterial sensitivity to 5-hydroxytryptamine

1990 • 40 citations

Endothelin induces an initial increase in cardiac output associated with selective vasodilation in rats

1989 • 39 citations

Abluminal effects of endothelin in cerebral microvasculature assessed by laser-Doppler flowmetry

1990 • 38 citations

Control of renal function during intrarenal infusion of endothelin

1990 • 38 citations

G-proteins are involved in contractile responses of isolated mesenteric resistance arteries to agonists

1990 • 36 citations

Thrombin stimulates the production of immunoreactive endothelin-1 in cultured human umbilical vein endothelial cells

1990 • 36 citations

Positive inotropic action, natriuresis and atrial natriuretic factor release induced by endothelin in the conscious rat

1990 • 35 citations

Endothelin- and oxytocin-induced calcium signaling in cultured human myometrial cells.

1991 • 34 citations

Endothelin activates the vascular renin-angiotensin system in rat mesenteric arteries.

1990 • 34 citations

Endothelin isopeptides evoke Ca2+ signaling and oscillations of cytosolic free [Ca2+] in human mesangial cells

1990 • 34 citations

Endothelin-like pulmonary vasoconstrictor peptide release by alpha-thrombin.

1989 • 34 citations

Hemodynamic and tubular effects of endothelin and thromboxane in the isolated perfused rat kidney

1989 • 33 citations

Effects of endothelin on renal regional blood flow in dogs

1989 • 33 citations

Cardiovascular and renal actions of endothelin: effects of calcium-channel blockers

1990 • 33 citations

Vasodilation induced by endothelin: role of EDRF and prostanoids in rat hindquarters

1990 • 32 citations

Hemodynamic effect of human and rat endothelin administration into conscious rats

1990 • 32 citations

Vasodilator Action of Endothelin-1 in the Perfused Rat Heart

1990 • 32 citations

Role of endothelium in the response to endothelin in hypertension.

1990 • 32 citations

Endothelins release tissue plasminogen activator and prostanoids

1990 • 31 citations

Evolution of the sarafotoxin/endothelin superfamily of proteins

1991 • 31 citations

Endothelial Cell-Derived Vasoconstrictors

1989 • 31 citations

Vasoactive intestinal contractor, a novel peptide, shares a common receptor with endothelin-1 and stimulates Ca2+ mobilization and DNA synthesis in Swiss 3T3 cells

1990 • 30 citations

Role of thromboxane receptor activation in the bronchospastic response to endothelin

1990 • 30 citations

Effects of endothelin on renal function in dogs and rats

1990 • 30 citations

Endothelial Control of Vascular Tone and Growth

1990 • 29 citations

Agonist-mediated changes in intracellular pH: role in vascular smooth muscle cell function.

1988 • 28 citations

Endothelin evoked Ca2+ transients and oscillations in A10 vascular smooth muscle cells

1989 • 28 citations

Endothelin and eicosanoid synthesis in cultured mesangial cells

1990 • 28 citations

Functional Role of Muscarinic Acetylcholine Receptor Subtype Diversity

1988 • 28 citations

Endothelin reduces microvascular blood flow by acting on and venules of the hamster cheek pouch

1990 • 28 citations

Effect of endothelins on cytosolic free calcium concentration in neuroblastoma NG108-15 and NCB-20 cells

1990 • 27 citations

Analysis of big endothelin-1 digestion by cathepsin D

1990 • 27 citations

Endothelin and Sarafotoxin Produce Dissimilar Effects on Renal Blood Flow, But Both Block the Antidiuretic Effects of Vasopressin

1989 • 26 citations

Endothelin-1 and -3 induce the release of tissue-type plasminogen activator and Von Willebrand factor from endothelial cells

1990 • 25 citations

Response of Isolated Intracerebral Arterioles to Endothelins

1990 • 25 citations

Endothelin-induced constriction of guinea pig airways: Role of platelet-activating factor

1990 • 24 citations

Mitogenic activity of endothelin-1 and -3 on vascular smooth muscle cells is inhibited by atrial natriuretic peptides.

1990 • 24 citations

Effect of endothelin-1, endothelin-3 and C-terminal hexapeptide, endothelin (16–21) on motor activity in rats

1990 • 24 citations

From Membrane to Nucleus: The Pathway of Signal Transduction in Yeast and Its Genetic Control

1988 • 23 citations

Cyclooxygenase products and atrial natriuretic peptide modulate renal response to endothelin.

1990 • 23 citations

Efficacy of nifedipine to prevent systemic and renal vasoconstrictor effects of endothelin

1990 • 19 citations

Proteolytic processing of porcine big endothelin-1 catalyzed by cathepsin D

1990 • 19 citations

Endothelial factors in the regulation of renin release

1990 • 19 citations

Role of endogenous endothelin on renal functions in rats

1991 • 17 citations

The effect of extracellular calcium on the contractile action of endothelin

1990 • 17 citations

Regional hemodynamic effects of endothelin-2 and sarafotoxin-S6b in conscious rats

1990 • 16 citations

A pertussis toxin-sensitive GTP-binding protein couples endothelin to phospholipase C in rat mesangial cells

1991 • 16 citations

SYSTEMIC AND REGIONAL EFFECTS OF ENDOTHELIN IN RABBITS: EFFECTS OF ENDOTHELIN ANTIBODY

1990 • 15 citations

Activities of endothelin‐1 in the vascular network of the rabbit ear: a microangiographic study

1990 • 12 citations

Glomerular endothelin receptors during initiation and maintenance of ischemic acute renal failure in rats

1991 • 12 citations

Iloprost antagonizes endothelin-induced vasoconstriction in macro- and microcirculation.

1990 • 11 citations

Comparison between the vasoactive actions of endothelin and arginine vasopressin in pithed rats after pretreatment with BAY K 8644, nifedipine or pertussis toxin.

1990 • 10 citations

Cardio-renal effects of endothelin-3 in the rat

1990 • 10 citations

Natiuretic and Diuretic Effects of Endothelin in Isolated Perfused Rat Kidney.

1989 • 8 citations

Calcium channel blockers reverse the sustained elevation of blood pressure induced by chronic infusion of endothelin in conscious rats.

1990 • 7 citations

Inhibition of endothelin‐mediated topoisomerase I activation by pertussis toxin

1990 • 5 citations

Stimulatory Action of Endothelin-1 on Membrane Na+ Transport in Vascular Smooth Muscle Cells in Culture

1990 • 4 citations