A role for neuropeptides in the control of cell proliferation

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene

1984 • 3,150 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

1983 • 1,657 citations

The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1

1985 • 1,590 citations

Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor

1983 • 1,550 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Induction of c-fos gene and protein by growth factors precedes activation of c-myc

1984 • 1,463 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer

1985 • 1,360 citations

Current Topics in Membranes and Transport

1970 • 1,240 citations

Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein

1984 • 949 citations

Isolation and structure of bombesin and alytesin, two analogous active peptides from the skin of the european amphibiansBombina andAlytes

1971 • 917 citations

Growth factors: Mechanism of action and relation to oncogenes

1984 • 885 citations

Characterization of a gastrin releasing peptide from porcine non-antral gastric tissue

1979 • 871 citations

Stimulation of connective tissue cell growth by substance P and substance K

1985 • 681 citations

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

1984 • 656 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

High Levels of Intracellular Bombesin Characterize Human Small-Cell Lung Carcinoma

1981 • 492 citations

Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells.

1983 • 470 citations

Specific stimulation of human T lymphocytes by substance P.

1983 • 461 citations

A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells

1985 • 456 citations

Substance P Activation of Rheumatoid Synoviocytes: Neural Pathway in Pathogenesis of Arthritis

1987 • 450 citations

A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in the guinea pig

1983 • 443 citations

Bombesin-like immunoreactivity in the lung

1978 • 439 citations

Bombesin suppresses feeding in rats

1979 • 394 citations

beta-Endorphin enhances lymphocyte proliferative responses.

1982 • 393 citations

Fate of immunoprecipitable protein kinase C in GH3 cells treated with phorbol 12-myristate 13-acetate.

1985 • 387 citations

Phorbol esters, phospholipase C, and growth factors rapidly stimulate the phosphorylation of a Mr 80,000 protein in intact quiescent 3T3 cells.

1983 • 377 citations

Neuromedin B: A novel bombesin-like peptide identified in porcine spinal cord

1983 • 372 citations

Limb Development and Regeneration

1987 • 357 citations

Bombesin and the C-terminal tetradecapeptide of gastrin-releasing peptide are growth factors for normal human bronchial epithelial cells

1984 • 354 citations

Molecular mechanisms of transmembrane signalling

1985 • 352 citations

Growth factor-stimulated protein phosphorylation in 3T3-L1 cells. Evidence for protein kinase C-dependent and -independent pathways.

1985 • 351 citations

Phorbol esters and vasopressin stimulate DNA synthesis by a common mechanism

1980 • 334 citations

Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms

1986 • 325 citations

Protein kinase C-stimulated phosphorylation in vitro of a Mr 80,000 protein phosphorylated in response to phorbol esters and growth factors in intact fibroblasts. Distinction from protein kinase C and prominence in brain.

1986 • 277 citations

Selective stimulation of small cell lung cancer clonal growth by bombesin and gastrin-releasing peptide

1987 • 269 citations

Interaction of vasoactive intestinal peptide with mouse lymphocytes: specific binding and the modulation of mitogen responses.

1984 • 266 citations

Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 cells: role of Ca2+-sensitive phospholipid-dependent protein kinase.

1984 • 266 citations

Substance P: binding properties and studies on cellular responses in guinea pig macrophages.

1986 • 262 citations

Neuropeptides and their receptors: a psychosomatic network

1985 • 259 citations

Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654.

1985 • 244 citations

Cloning and characterization of cDNAs encoding human gastrin-releasing peptide.

1984 • 239 citations

New Aspects of the Trophic Action Of Gastrointestinal Hormones

1977 • 227 citations

Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. I. Activation of protein kinase C and inhibition of epidermal growth factor binding.

1986 • 225 citations

Neuromedin C: A bombesin-like peptide identified in porcine spinal cord

1984 • 223 citations

Gastrin releasing peptide is a selective mitogen for small cell lung carcinoma in vitro.

1985 • 216 citations

Vasopressin stimulation of mouse 3T3 cell growth.

1979 • 210 citations

Stimulation of DNA synthesis by tumour promoter and pure mitogenic factors

1978 • 207 citations

High-affinity receptors for peptides of the bombesin family in Swiss 3T3 cells.

1985 • 202 citations

Reduction of epidermal growth factor receptor affinity by heterologous ligands: Evidence for a mechanism involving the breakdown of phosphoinositides and the activation of protein kinase C

1984 • 197 citations

Bombesin-like peptides in mammals.

1979 • 188 citations

BOMBESIN,SOMATOSTATIN AND NEUROTENSIN-LIKE IMMUNOREACTIVITY IN BRONCHIAL CARCINOMA

1981 • 186 citations

Bombesin, bombesin analogs, and related peptides: effects on thermoregulation

1978 • 186 citations

Effects of bombesin and insulin on inositol (1,4,5) trisphosphate and inositol (1,3,4) trisphosphate formation in Swiss 3T3 cells

1986 • 185 citations

Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs.

1986 • 184 citations

Human lung small-cell carcinoma contains bombesin.

1982 • 184 citations

NEUROPEPTIDES: MULTIPLE MOLECULAR FORMS, METABOLIC PATHWAYS, AND RECEPTORS

1986 • 177 citations

The effects of bombesin on polyphosphoinositide and calcium metabolism in Swiss 3T3 cells.

1987 • 175 citations

Stereospecific receptors for substance P on cultured human IM-9 lymphoblasts.

1984 • 173 citations

A synthetic peptide that is a bombesin receptor antagonist

1984 • 171 citations

Pertussis Toxin-Sensitive Pathway in the Stimulation of c- myc Expression and DNA Synthesis by Bombesin

1986 • 171 citations

Serum, platelet-derived growth factor, vasopressin and phorbol esters increase intracellular pH in Swiss 3T3 cells

1983 • 170 citations

Binding of phorbol esters to high‐affinity sites on murine fibroblastic cells elicits a mitogenic response

1982 • 167 citations

Vasoactive intestinal peptide and neuropeptide modulation of the immune response

1985 • 165 citations

Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. II. Changes in Na+ and Ca2+ fluxes, Na+/K+ pump activity, and intracellular pH.

1986 • 164 citations

Brain regulation of gastric secretion: influence of neuropeptides.

1980 • 160 citations

Mitogenic Growth Factors and Nerve Dependence of Limb Regeneration

1984 • 154 citations

Production and molecular size heterogeneity of immunoreactive gastrin-releasing peptide in fetal and adult lungs and primary lung tumors.

1983 • 151 citations

Phosphorylation of an acidic mol. wt. 80 000 cellular protein in a cell-free system and intact Swiss 3T3 cells: a specific marker of protein kinase C activity.

1986 • 147 citations

Bombesin-like peptides in rat brain: Quantitation and biochemical characterization

1979 • 145 citations

Modification of lymphocyte traffic by vasoactive neurotransmitter substances.

1984 • 135 citations

Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin-related peptide, gastrin-releasing peptide.

1986 • 132 citations

Role of gastrin and gastrin receptors on the growth of a transplantable mouse colon carcinoma (MC-26) in BALB/c mice.

1986 • 131 citations

Vasopressin inhibition of epidermal growth factor binding to cultured mouse cells.

1981 • 130 citations

Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: Evidence for a role of protein kinase C

1987 • 127 citations

Ca2+-mobilizing actions of platelet-derived growth factor differ from those of bombesin and vasopressin in Swiss 3T3 mouse cells.

1987 • 126 citations

Quantitation of protein kinase C by immunoblot—expression in different cell lines and response to phorbol esters

1987 • 114 citations

Identification of a receptor for peptides of the bombesin family in Swiss 3T3 cells by affinity cross-linking.

1987 • 114 citations

Stimulation of DNA Synthesis in Quiescent Cultured Cells: Exogenous Agents, Internal Signals, and Early Events

1980 • 113 citations

Serum, like phorbol esters, rapidly activates protein kinase C in intact quiescent fibroblasts.

1985 • 110 citations

Secretin/vasoactive intestinal peptide-stimulated secretion of bombesin/gastrin releasing peptide from human small cell carcinoma of the lung

1987 • 109 citations

Receptor-mediated mitogenic effects of substance P on cultured smooth muscle cells

1985 • 105 citations

Growth of Pancreas and Gastrointestinal Mucosa in Antrectomized and Gastrin-Treated Rats*

1979 • 103 citations

Bombesin production by human small cell carcinoma of the lung

1982 • 100 citations

Protein kinase C activation enhances cAMP accumulation in Swiss 3T3 cells: inhibition by pertussis toxin.

1987 • 100 citations

Inhibition of epidermal growth factor binding to mouse cultured cells by fibroblast-derived growth factor. Evidence for an indirect mechanism.

1982 • 90 citations

Similarities between fibroblast-derived growth factor and platelet-derived growth factor

1981 • 90 citations

Stimulating effect of bombesin on the growth of gastrointestinal tract and pancreas in suckling rats

1986 • 89 citations

NEURONAL PEPTIDES IN THE INTESTINE

1982 • 87 citations

Stimulation of DNA synthesis by transient exposure of cell cultures to TPA or polypeptide mitogens: Induction of competence or incomplete removal?

1981 • 86 citations

Bombesin and Vasoactive Intestinal Polypeptide in the Developing Lung: Marked Changes in Acute Respiratory Distress Syndrome*

1983 • 84 citations

Vasopressin modulates liver regeneration in the Brattleboro rat

1983 • 84 citations

Chronic administration of bombesin stimulates antral gastrin cell proliferation in the rat

1983 • 82 citations

Effects of gastrin on tumor growth and cyclic nucleotide metabolism in xenotransplantable human gastric and colonic carcinomas in nude mice.

1984 • 81 citations

Receptor for bombesin with associated tyrosine kinase activity.

1986 • 77 citations

Bombesin induction of c‐fos and c‐myc proto‐oncogenes in Swiss 3T3 cells: Significance for the mitogenic response

1987 • 77 citations

Bombesin-like peptides in small cell lung cancer: Biochemical characterization and secretion from a cell line

1983 • 76 citations

Effect of somatostatin on the proliferation of mouse spleen lymphocytes in, vitro

1985 • 76 citations

Growth responses of rat stomach cancer cells to gastro‐entero‐pancreatic hormones

1982 • 73 citations

Capsaicin: hot new pharmacological tool

1983 • 70 citations

Vasopressin rapidly stimulates NA entry and NA‐K pump activity in quiescent cultures of mouse 3T3 cells

1980 • 69 citations

Modulation of the epidermal growth factor receptor by mitogenic ligands: effects of bombesin and role of protein kinase C.

1985 • 69 citations

Identification of gastrin releasing peptide-related substances in guinea pig and rat brain

1983 • 64 citations

Histochemistry and function of bombesin-like peptides.

1986 • 64 citations

Bombesin stimulates insulin secretion by a pancreatic islet cell line.

1984 • 60 citations

Effect of bombesin and caerulein on early stages of carcinogenesis induced by azaserine in the rat pancreas.

1987 • 59 citations

Vasopressin and brain development: Studies using the Brattleboro rat

1985 • 58 citations

Effect of gastrin on gastric mucosal cell proliferation in man.

1976 • 57 citations

Vasopressin induces selective desensitization of its mitogenic response in Swiss 3T3 cells.

1983 • 56 citations

Growth factors: Neuropeptides as mitogens

1985 • 53 citations

Growth factors, cell proliferation and cancer: an overview.

1983 • 52 citations

Enhancement of [³H-Methyl]Thymidine Incorporation and Replication of Rat Chondrocytes Grown in Tissue Culture by Plasma, Tissue Extracts and Vasopressin¹

1977 • 50 citations

Internalization and degradation of peptides of the bombesin family in Swiss 3T3 cells occurs without ligand-induced receptor down-regulation.

1987 • 50 citations

Bombesin stimulation of c-fos and c-myc gene expression in cultures of Swiss 3T3 cells

1986 • 48 citations

Neuromedin B-32 and B-30: Two “big” neuromedin B identified in porcine brain and spinal cord

1985 • 46 citations

Gastrin-releasing peptide-related peptides in a human malignant lung carcinoid tumor.

1983 • 45 citations

ROLE OF VASOPRESSIN IN THE MITOTIC RESPONSE OF RAT BONE MARROW CELLS TO HAEMORRHAGE

1977 • 45 citations

Depletion of neuropeptides during wound healing in rat skin

1986 • 44 citations

A substance P antagonist also inhibits specific binding and mitogenic effects of vasopressin and bombesin-related peptides in Swiss 3T3 cells

1986 • 43 citations

Molecular aspects of growth factor action: Receptors and intracellular signals

1983 • 41 citations

Phorbol esters and diacylglycerol inhibit vasopressin-induced increases in cytoplasmic-free Ca2+ and 45Ca2+ efflux in Swiss 3T3 cells

1986 • 39 citations

Vasopressin rapidly stimulates protein kinase C in quiescent Swiss 3T3 cells

1986 • 39 citations

Characterisation of bombesin-like immunoreactivity in human fetal lung

1983 • 35 citations

Bombesin in human and guinea pig alveolar macrophages.

1986 • 34 citations

Chapter 5 Early Stimulation of Na+-H+Antiport, Na+-K+Pump Activity, and Ca2+Fluxes in Fibroblast Mitogenesis

1986 • 34 citations

Protein Phosphorylation in a Tetradecanoyl Phorbol Acetate-Nonproliferative Variant of 3T3 Cells

1985 • 31 citations

Cyclic AMP: a growth-promoting signal for mouse 3T3 cells.

1981 • 31 citations

Chemical messengers: a view from the gut.

1979 • 30 citations

Vasopressin rapidly stimulates Ca2+ efflux from intracellular pool in quiescent Swiss 3T3 cells

1984 • 30 citations

Highly purified fibroblast-derived growth factor, an SV40-transformed fibroblast-secreted mitogen, is closely related to platelet-derived growth factor.

1985 • 30 citations

Neuroimmunomodulation

1988 • 28 citations

Protein phosphorylation in a tetradecanoyl phorbol acetate-nonproliferative variant of 3T3 cells.

1985 • 19 citations

Neurotrophic effects of beta endorphin C-terminal tetrapeptide (MPF)

1986 • 16 citations