Endothelins: a family of regulatory peptides. State-of-the-art lecture.

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

1988 • 1,417 citations

Peptide growth factors are multifunctional

1988 • 835 citations

Endothelin stimulates c‐fos and c‐myc expression and proliferation of vascular smooth muscle cells

1988 • 737 citations

Endothelin stimulates phospholipase C, Na+/H+ exchange, c-fos expression, and mitogenesis in rat mesangial cells.

1989 • 561 citations

A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts

1989 • 485 citations

Integrated cardiac, renal, and endocrine actions of endothelin.

1989 • 481 citations

Endothelin in brain: receptors, mitogenesis, and biosynthesis in glial cells.

1990 • 480 citations

The Human Preproendothelin-1 Gene

1989 • 441 citations

Mesangial cell, glomerular and renal vascular responses to endothelin in the rat kidney. Elucidation of signal transduction pathways.

1989 • 413 citations

Cellular signaling by peptides of the endothelin gene family

1990 • 391 citations

Role of endothelin in cyclosporine-induced glomerular dysfunction

1990 • 368 citations

Endothelin, a novel endothelium-derived peptide

1989 • 365 citations

Glomerular actions of endothelin in vivo.

1989 • 351 citations

Endothelin 1, an endothelium-derived peptide, is expressed in neurons of the human spinal cord and dorsal root ganglia.

1989 • 349 citations

Positive inotropic action of novel vasoconstrictor peptide endothelin on guinea pig atria

1988 • 347 citations

Endothelin: A Novel Peptide in the Posterior Pituitary System

1990 • 313 citations

Endothelin, a peptide inhibitor of Na(+)-K(+)-ATPase in intact renaltubular epithelial cells

1989 • 285 citations

Cardiovascular, renal, and endocrine responses to intravenous endothelin in conscious dogs

1988 • 279 citations

2,5-Di-(tert-butyl)-1,4-benzohydroquinone rapidly elevates cytosolic Ca2+ concentration by mobilizing the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool

1989 • 261 citations

A Novel Peptide, Vasoactive Intestinal Contractor, of a New (Endothelin) Peptide Family

1989 • 260 citations

Endothelin is a positive inotropic agent in human and rat heart in, vitro

1989 • 235 citations

Endothelin: a potent renal and systemic vasoconstrictor peptide

1989 • 232 citations

Expression of the potent vasoconstrictor endothelin in the human central nervous system.

1990 • 228 citations

ENDOTHELIN: AN IMPORTANT FACTOR IN ACUTE RENAL FAILURE?

1988 • 214 citations

Rapid release of endothelin and ATP from isolated aortic endothelial cells exposed to increased flow

1990 • 211 citations

Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptide

1988 • 203 citations

Structural Organization and Chromosomal Assignment of the Gene Encoding Endothelin

1989 • 178 citations

Endothelin Stimulation of Cytosolic Calcium and Gonadotropin Secretion in Anterior Pituitary Cells

1990 • 172 citations

Functional analysis of the endothelin-1 gene promoter. Evidence for an endothelial cell-specific cis-acting sequence.

1990 • 170 citations

cDNA cloning and chromosomal assignment of the gene encoding endothelin 3

1989 • 167 citations

Stimulation of Phosphatidylinositol Hydrolysis, Diacylglycerol Release, and Gene Expression in Response to Endothelin, a Potent New Agonist for Fibroblasts and Smooth Muscle Cells

1989 • 166 citations

Heterogeneity of cell surface endothelin receptors.

1990 • 159 citations

Similarities in mode and sites of action of sarafotoxins and endothelins

1989 • 152 citations

Effects of endothelin on peptide-dependent cyclic adenosine monophosphate accumulation along the nephron segments of the rat.

1990 • 127 citations

The Discovery, the Present State, and the Future Prospects of Endothelin

1989 • 123 citations

Endothelin augments unitary calcium channel currents on the smooth muscle cell membrane of guinea‐pig portal vein.

1990 • 113 citations

Inhibition of adrenergic neuroeffector transmission by endothelin in the guinea‐pig femoral artery

1988 • 112 citations

Production of endothelin-1 by rat cultured mesangial cells

1990 • 108 citations

The inotropic effect of endothelin‐1 on rat atria involves hydrolysis of phosphatidylinositol

1989 • 102 citations

Endothelin stimulates DNA synthesis in Swiss 3T3 cells. Synergy with polypeptide growth factors

1989 • 98 citations

Influence of endothelin on human coronary arteries and localization of its binding sites

1989 • 93 citations

Lethal ischemia due to intracoronary endothelin in pigs

1989 • 89 citations

Endothelin. Pathways of transmembrane signaling.

1990 • 78 citations

The structural characterization of beta-endorphin and related peptide hormones and neurotransmitters.

1986 • 72 citations

Endothelin increases single‐channel calcium currents in coronary arterial smooth muscle cells

1989 • 67 citations

Endothelin Enhances Adrenocorticotropin-Stimulated Aldosterone Release from Cultured Bovine Adrenal Cells*

1990 • 63 citations

Ca2+ signaling by distinct endothelin peptides in glomerular mesangial cells

1991 • 63 citations

Endothelin-1 stimulates DNA synthesis and anchorage-independent growth of Rat-1 fibroblasts through a protein kinase C-dependent mechanism.

1990 • 50 citations

Endothelin isopeptides evoke Ca2+ signaling and oscillations of cytosolic free [Ca2+] in human mesangial cells

1990 • 34 citations

Cross-linking of endothelin 1 and endothelin 3 to rat brain membranes: identification of the putative receptor(s)

1990 • 23 citations

Deleted Work

1955 • 0 citations