Individual Cell Analysis of the Cytokine Repertoire in Human Immunodeficiency Virus-1–Infected Monocytes/Macrophages by a Combination of Immunocytochemistry and In Situ Hybridization

Cellular uptake of the tat protein from human immunodeficiency virus

1988 • 2,690 citations

The Role of Mononuclear Phagocytes in HTLV-III/LAV Infection

1986 • 1,828 citations

The Human Hematopoietic Colony-Stimulating Factors

1987 • 1,728 citations

CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

1990 • 1,304 citations

The Neutrophil-Activating Protein (NAP-1) Is Also Chemotactic for T Lymphocytes

1989 • 1,060 citations

Pathogenesis of human immunodeficiency virus infection

1993 • 835 citations

A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence.

1990 • 770 citations

Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome

1988 • 739 citations

The Th1–Th2 hypothesis of HIV infection: new insights

1994 • 708 citations

How Does HIV Cause AIDS?

1993 • 668 citations

A novel neutrophil-activating factor produced by human mononuclear phagocytes.

1988 • 655 citations

Infection with HIV is associated with elevated IL-6 levels and production.

1990 • 594 citations

Endocytosis and targeting of exogenous HIV-1 Tat protein.

1991 • 481 citations

Hematopoietic Growth Factors

1989 • 465 citations

Pathogenesis of human immunodeficiency virus infection.

1993 • 455 citations

In vitro infection of human monocytes with human T lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV).

1986 • 346 citations

Interleukin-1 and tumor necrosis factor alpha can be induced from mononuclear phagocytes by human immunodeficiency virus type 1 binding to the CD4 receptor

1989 • 331 citations

Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV.

1989 • 314 citations

Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokines

1992 • 289 citations

Role of Mononuclear Phagocytes in the Pathogenesis of Human Immunodeficiency Virus Infection

1990 • 277 citations

The neuropathogenesis of HIV-1 infection

1994 • 277 citations

Induction of interleukin-6 during human immunodeficiency virus infection

1990 • 191 citations

Spontaneous cytotoxicity and tumor necrosis factor production by peripheral blood monocytes from AIDS patients.

1988 • 187 citations

Cytokines in disease

1990 • 176 citations

Production of tumor necrosis factor alpha and interleukin 1 beta by monocytic cells infected with human immunodeficiency virus.

1989 • 172 citations

Primary cultures of human blood-born macrophages grown on hydrophobic teflon membranes

1983 • 171 citations

Interleukin 1 beta is localized in the cytoplasmic ground substance but is largely absent from the Golgi apparatus and plasma membranes of stimulated human monocytes.

1988 • 152 citations

A regulatory role for astrocytes in HIV-1 encephalitis. An overexpression of eicosanoids, platelet-activating factor, and tumor necrosis factor-alpha by activated HIV-1-infected monocytes is attenuated by primary human astrocytes.

1995 • 137 citations

HIV-1 TAT “activates” presynthesized RNA in the nucleus

1989 • 135 citations

Human immunodeficiency virus 1 Tat binds to dipeptidyl aminopeptidase IV (CD26): a possible mechanism for Tat's immunosuppressive activity.

1994 • 133 citations

Macrophage-Derived Growth Factors

1992 • 131 citations

Subcellular localization of human monocyte interleukin 1: evidence for an inactive precursor molecule and a possible mechanism for IL 1 release.

1987 • 118 citations

Dipeptidyl peptidase IV (CD 26) and aminopeptidase N (CD 13) catalyzed hydrolysis of cytokines and peptides with N‐terminal cytokine sequences

1993 • 118 citations

Mononuclear Cell Adherence Induces Neutrophil Chemotactic Factor/Interleukin-8 Gene Expression

1991 • 113 citations

Role of endotoxin in mononuclear phagocyte-mediated inflammatory responses

1994 • 104 citations

Human Monocyte Interleukin-1β Posttranslational Processing

1996 • 102 citations

Mechanisms of HIV/SIV Mucosal Transmission

1994 • 101 citations

Dysregulation of Interleukin 8, Interleukin 10, and Interleukin 12 Release by Alveolar Macrophages from HIV Type 1-Infected Subjects

1994 • 101 citations

Human immunodeficiency virus does not induce interleukin-1, interleukin-6, or tumor necrosis factor in mononuclear cells

1990 • 98 citations

Identification of a novel integrin beta subunit expressed on cultured monocytes (macrophages). Evidence that one alpha subunit can associate with multiple beta subunits.

1990 • 95 citations

Elevated serum levels of IL-8 in patients with HIV infection

1993 • 89 citations

Alveolar macrophages in AIDS patients: increased spontaneous tumour necrosis factor-alpha production inPneumocystis cariniipneumonia

1990 • 87 citations

Tumor necrosis factor production in HIV-seropositive subjects. Relationship with lung opportunistic infections and HIV expression in alveolar macrophages.

1991 • 79 citations

Differential regulation of proinflammatory and hematopoietic cytokines in human macrophages after infection with human immunodeficiency virus

1996 • 75 citations

Human U937 cell surface peptidase activities: characterization and degradative effect on tumor necrosis factor‐α

1992 • 73 citations

HIV infection is associated with the spontaneous production off interleukin-1 (IL-1) in vivo and with an abnormal release off IL-1αaL in vitro

1989 • 69 citations

Human interleukin 6 and tumor necrosis factor α production studied at a single‐cell level

1989 • 61 citations

MINIREVIEW: Cytokines: An Expanding Network of Immuno-lnflammatory Hormones

1988 • 54 citations

Secretory Repertoire of HIV-Infected Human Monocytes/Macrophages

1991 • 54 citations

Identification of individual tumor necrosis factor/ cachectin‐producing cells after lipopolysaccharide induction

1988 • 51 citations

Cytokine dysregulation in AIDS: in vivo overexpression of mRNA of tumor necrosis factor-alpha and its correlation with that of the inflammatory cytokine GRO.

1992 • 50 citations

Leukotriene B4 and lnterleukin-8 in Human Immunodeficiency Virus-related Pulmonary Disease

1993 • 50 citations

Alveolar Macrophages from Patients with AIDS and AIDS-related Complex Constitutively Synthesize and Release Tumor Necrosis Factor Alpha

1991 • 50 citations

Spontaneous Production of Interleukin-6 by Alveolar Macrophages from Human Immunodeficiency Virus Type 1-Infected Patients

1992 • 48 citations

Expression and cleavage of tumor necrosis factor‐α and tumor necrosis factor receptors by human monocytic cell lines upon direct contact with stimulated T cells

1996 • 47 citations

Infection of monocytes/macrophages by HIV in vitro

1990 • 45 citations

Serum tumor necrosis factor alpha, interleukin 1-beta, p24 antigen concentrations and CD4+ cells at various stages of human immunodeficiency virus 1 infection in children

1991 • 41 citations

Interleukin‐1 stimulates tumor necrosis factor‐α (TNF‐α) release from cytotrophoblastic BeWo cells independently of induction of the TNF‐α mRNA

1997 • 29 citations

Interleukin-6 Expression in Primary Macrophages Infected with Human Immunodeficiency Virus-1 (HIV-1)

1991 • 24 citations

Granulocyte‐Macrophage Colony‐Stimulating Factor and Tumor Necrosis Factor Alpha in Patients with Human Immunodeficiency Virus (HIV) Type 1 Infection

1993 • 23 citations

HIV-1 Tat induces cytokine synthesis by uninfected mononuclear cells

1994 • 20 citations

Flow-Cytometric Assessment ofin VivoCytokine-Producing Monocytes in HIV-Infected Patients

1997 • 19 citations

Impaired GM‐CSF production by cultured light density mononuclear cells and T lymphocytes correlates with the number of circulating CFU‐gm in HTV‐1 seropositive subjects

1991 • 15 citations

Expression of macrophage products after in vitro infection of human monocytes/macrophages with HIV

1993 • 12 citations

Erythropoietin and Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Levels in Sera of Patients with HIV Infection

1991 • 9 citations