Interleukin-1 and tumor necrosis factor alpha can be induced from mononuclear phagocytes by human immunodeficiency virus type 1 binding to the CD4 receptor

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

1984 • 3,530 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

1984 • 2,441 citations

The Role of Mononuclear Phagocytes in HTLV-III/LAV Infection

1986 • 1,828 citations

Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy

1986 • 1,694 citations

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

1986 • 1,501 citations

Human tumor necrosis factor. Production, purification, and characterization.

1985 • 922 citations

Interleukin 1 of the central nervous system is produced by ameboid microglia.

1986 • 858 citations

Dual Infection of the Central Nervous System by AIDS Viruses with Distinct Cellular Tropisms

1987 • 831 citations

Tumor Necrosis Factor (Cachectin) as an Essential Mediator in Murine Cerebral Malaria

1987 • 749 citations

Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome

1988 • 739 citations

Monokine regulation of human immunodeficiency virus-1 expression in a chronically infected human T cell clone.

1989 • 544 citations

soluble form of CD4 (T4) protein inhibits AIDS virus infection

1988 • 530 citations

Cytokines Alter Production of HIV-1 from Primary Mononuclear Phagocytes

1988 • 486 citations

Prostaglandins posttranscriptionally inhibit monocyte expression of interleukin 1 activity by increasing intracellular cyclic adenosine monophosphate.

1986 • 462 citations

HIV infection is blocked in vitro by recombinant soluble CD4

1988 • 446 citations

A soluble CD4 protein selectively inhibits HIV replication and syncytium formation

1988 • 425 citations

The CD4 antigen: Physiological ligand and HIV receptor

1988 • 413 citations

Soluble CD4 molecules neutralize human immunodeficiency virus type 1

1988 • 403 citations

Immunohistochemical identification of HTLV‐III antigen in brains of patients with AIDS

1986 • 380 citations

Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV.

1989 • 314 citations

Regulation of tumor necrosis factor/cachectin and IL-1 secretion in human mononuclear phagocytes.

1988 • 278 citations

Human immunodeficiency virus glycoprotein (gp120) induction of monocyte arachidonic acid metabolites and interleukin 1.

1989 • 270 citations

Neurologic Manifestations of Infection with Human Immunodeficiency Virus

1987 • 241 citations

Tumor necrosis factor induction by Sendai virus.

1986 • 177 citations

Tumor necrosis factor alpha/cachectin is a growth factor for thymocytes. Synergistic interactions with other cytokines.

1988 • 164 citations

HIV-1 Production from Infected Peripheral Blood T Cells After HTLV-I Induced Mitogenic Stimulation

1988 • 157 citations

Cerebral infarctions and transiet neurologic deficits associated with acquired immunodeficiency syndrome

1989 • 153 citations

IL-1 and IFN-gamma increase vascular permeability.

1988 • 131 citations

A rapid biologic assay for the detection of interleukin 1.

1983 • 117 citations

Cytokines alter production of HIV-1 from primary mononuclear phagocytes

1988 • 111 citations

Tumor necrosis factor amplifies measles virus-mediated Ia induction on astrocytes.

1987 • 111 citations

Efficacy of alprazolam for essential tremor

1988 • 99 citations

Idiopathic production of interleukin-1 in acquired immune deficiency syndrome

1987 • 91 citations

Comodulation of CD3 and CD4. Evidence for a specific association between CD4 and approximately 5% of the CD3:T cell receptor complexes on helper T lymphocytes.

1988 • 89 citations

Long terminal repeats of human T-cell leukaemia virus II genome determine target cell specificity

1984 • 84 citations

Nucleotide sequence of the 3' region of an infectious human T-cell leukemia virus type II genome.

1984 • 79 citations

Lymphomatoid granulomatosis and malignant lymphoma of the central nervous system in the acquired immunodeficiency syndrome

1989 • 78 citations

Coaggregation of the T-cell receptor with CD4 and other T-cell surface molecules enhances T-cell activation.

1987 • 71 citations

CD4 is involved in a post-binding event in the cytolytic reaction mediated by human CD4+ cytotoxic T lymphocyte clones.

1988 • 20 citations