Effects of Hyperglycemia on Vascular Endothelium Nitric Oxide Metabolism

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications

1988 • 2,527 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN

1989 • 1,625 citations

Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

1981 • 1,624 citations

ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM

1987 • 1,450 citations

Nitric oxide synthase structure and mechanism

1993 • 1,342 citations

Glucose autoxidation and protein modification. The potential role of ‘autoxidative glycosylation’ in diabetes

1987 • 1,278 citations

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.

1990 • 1,209 citations

Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.

1991 • 1,161 citations

Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.

1993 • 1,102 citations

Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions.

1994 • 1,102 citations

Impaired Neurogenic and Endothelium-Mediated Relaxation of Penile Smooth Muscle from Diabetic Men with Impotence

1989 • 960 citations

Impaired endothelium-dependent and independent vasodilation in patients with Type 2 (non-insulin-dependent) diabetes mellitus

1992 • 922 citations

Sorbitol, Phosphoinositides, and Sodium-Potassium-ATPase in the Pathogenesis of Diabetic Complications

1987 • 905 citations

Structure and mechanism

1989 • 843 citations

Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites.

1992 • 621 citations

Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction

1992 • 609 citations

Free radicals mediate endothelial cell dysfunction caused by elevated glucose

1992 • 566 citations

Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes.

1992 • 527 citations

Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.

1991 • 429 citations

Free radicals in diabetic endothelial cell dysfunction

1994 • 398 citations

Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta.

1990 • 375 citations

Attenuation of endothelium-dependent relaxation in aorta from diabetic rats

1986 • 350 citations

Phosphorylation and subcellular translocation of endothelial nitric oxide synthase.

1993 • 329 citations

Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose.

1989 • 324 citations

Release of intact endothelium-derived relaxing factor depends on endothelial superoxide dismutase activity

1991 • 322 citations

Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation

1993 • 306 citations

Impairment of endothelium‐dependent relaxation and changes in levels of cyclic GMP in aorta from streptozotocin‐induced diabetic rats

1989 • 294 citations

Prevention of Diabetic Vascular Dysfunction by Guanidines: Inhibition of Nitric Oxide Synthase Versus Advanced Glycation End-Product Formation

1993 • 289 citations

Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta

1991 • 283 citations

Impairment of endothelium‐dependent relaxation in aortae from spontaneously diabetic rats

1988 • 255 citations

Contraction of diabetic rabbit aorta caused by endothelium-derived PGH2-TxA2

1989 • 245 citations

Increase in Diacylglycerol Mass in Isolated Glomeruli by Glucose From De Novo Synthesis of Glycerolipids

1990 • 219 citations

Impaired contraction and relaxation in aorta from streptozotocin-diabetic rats: Role of polyol pathway

1992 • 216 citations

Advanced glycosylation endproducts block the antiproliferative effect of nitric oxide. Role in the vascular and renal complications of diabetes mellitus.

1992 • 215 citations

Inhibition of coronary artery superoxide dismutase attenuates endothelium-dependent and -independent nitrovasodilator relaxation.

1991 • 215 citations

Inhibition of Nitric Oxide Synthesis in Forearm Vasculature of Insulin-Dependent Diabetic Patients: Blunted Vasoconstriction in Patients with Microalbuminuria

1993 • 214 citations

The linked roles of nitric oxide, aldose reductase and, (Na+,K+)-ATPase in the slowing of nerve conduction in the streptozotocin diabetic rat.

1994 • 205 citations

Decreased vascular prostacyclin in experimental diabetes

1978 • 203 citations

Enhanced secretion of endothelin‐1 by elevated glucose levels from cultured bovine aortic endothelial cells

1990 • 196 citations

Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta

1988 • 193 citations

Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction

1992 • 192 citations

Continuous Monitoring of Nitric Oxide Release from Human Umbilical Vein Endothelial Cells

1993 • 192 citations

Diacylglycerol accumulation and microvascular abnormalities induced by elevated glucose levels.

1991 • 191 citations

The dopamine autoreceptor agonist B-HT 920 stimulates denervated postsynaptic brain dopamine receptors in rodent and primate models of Parkinson's disease: a novel approach to treatment

1986 • 183 citations

Impairment of endothelium-dependent dilatation of cerebral arterioles during diabetes mellitus

1989 • 174 citations

Platelet hyperaggregation and increased plasma level of von Willebrand factor in diabetics with retinopathy

1975 • 167 citations

Direct Measurement of Polyol Pathway Activity in the Ocular Lens

1984 • 153 citations

Glucose‐induced metabolic imbalances in the pathogenesis of diabetic vascular disease

1991 • 151 citations

Endothelium-Dependent Relaxation in Aorta of BB Rat

1987 • 151 citations

Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat

1993 • 148 citations

Diabetes and Atherosclerosis: an Overview

1981 • 146 citations

Endothelium‐dependent relaxation and noradrenaline sensitivity in mesenteric resistance arteries of streptozotocin‐induced diabetic rats

1992 • 140 citations

Stimulation of de novo synthesis of prostaglandin G/H synthase in human endothelial cells by phorbol ester.

1988 • 132 citations

Superoxide release by neutrophils: Synergistic effects of a phorbol ester and a calcium ionophore

1984 • 129 citations

Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response.

1994 • 128 citations

Endothelium-Dependent Vascular Relaxation in Patients With Type I Diabetes

1993 • 124 citations

Pertussis toxin abolishes angiotensin II-induced phosphoinositide hydrolysis and prostaglandin synthesis in rat renal mesangial cells

1986 • 122 citations

Characterization of Glucose-Induced In Situ Protein Kinase C Activity in Cultured Vascular Smooth Muscle Cells

1992 • 118 citations

Endothelium-dependent inhibition of Na(+)-K+ ATPase activity in rabbit aorta by hyperglycemia. Possible role of endothelium-derived nitric oxide.

1992 • 115 citations

Phosphorylation of nitric oxide synthase by protein kinase A

1991 • 114 citations

Aldose Reductase Inhibition Restores Endothelial Cell Function in Diabetic Rabbit Aorta

1993 • 95 citations

Role of superoxide anion and endothelium in vasoconstrictor action of prostaglandin endoperoxide

1992 • 90 citations

Immunohistochemical distribution of aldose reductase

1982 • 77 citations

Endothelium-dependent relaxation in aorta of BB rat

1987 • 76 citations

Role of phospholipase C and protein kinase C in vasoconstrictor-induced prostaglandin synthesis in cultured rat renal mesangial cells

1986 • 75 citations

Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation

1993 • 71 citations

Aldose reductase inhibitors: An approach to the treatment of diabetic nerve damage

1993 • 69 citations

Pathogenesis of diabetic neuropathy: role of altered phosphoinositide metabolism.

1989 • 68 citations

Decrease in endothelium-dependent relaxation and levels of cyclic nucleotides in aorta from rabbits with alloxan-induced diabetes.

1990 • 67 citations

Matrix-derived soluble components influence type II pneumocytes in primary culture

1989 • 67 citations

Endothelium‐dependent increase in vascular sensitivity to phenylephrine in long‐term streptozotocin diabetic rat aorta

1992 • 62 citations

Direct measurement of polyol pathway activity in the ocular lens

1984 • 58 citations

Increased prostacyclin release from perfused hearts of acutely diabetic rats

1980 • 47 citations

Increase in diacylglycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids

1990 • 46 citations

Changes in endothelium-dependent relaxation and levels of cyclic nucleotides in the perfused mesenteric arterial bed from streptozotocin-induced diabetic rats

1993 • 37 citations

Characterization of glucose-induced in situ protein kinase C activity in cultured vascular smooth muscle cells

1992 • 32 citations

Effects of glucose on sorbitol pathway activation, cellular redox, and metabolism of myo-inositol, phosphoinositide, and diacylglycerol in cultured human retinal pigment epithelial cells.

1994 • 32 citations

Effects of glucose, insulin or aldose reductase inhibition on responses to endothelin‐1 of aortic rings from streptozotocin‐induced diabetic rats

1992 • 30 citations

Endothelium-dependent vascular relaxation in patients with type I diabetes

1993 • 29 citations

1,2-Diacylglycerol Content and Its Fatty Acid Composition in Thoracic Aorta of Diabetic Rats

1991 • 17 citations

Duration-dependent attenuation of acetylcholine—but not histamine—induced relaxation of the aorta in diabetes mellitus

1993 • 11 citations

1,2-diacylglycerol content and its fatty acid composition in thoracic aorta of diabetic rats

1991 • 8 citations

Effect of Glucose on Na, K-ATPase Activity in Cultured Bovine Aortic Endothelial Cells.

1992 • 5 citations