Cytochrome P450 and the Metabolism of Arachidonic Acid and Oxygenated Eicosanoids

Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects

1987 • 2,237 citations

ARACHIDONIC ACID METABOLISM

1986 • 1,802 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature

1993 • 1,663 citations

The molecular biology of cytochrome P450s.

1988 • 1,294 citations

Oxygen Activation by Cytochrome P-4501

1980 • 1,013 citations

Aspirin and the potential role of prostaglandins in colon cancer.

1992 • 694 citations

Resolution of the Cytochrome P-450-containing ω-Hydroxylation System of Liver Microsomes into Three Components

1969 • 573 citations

Structure of Biological Membranes

1966 • 545 citations

Mechanisms and Consequences of Lipid Peroxidation in Biological Systems

1985 • 520 citations

Prostaglandin and thromboxane biosynthesis

1991 • 444 citations

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue

1989 • 382 citations

5-LIPOXYGENASE

1994 • 357 citations

Dahl salt-susceptible and salt-resistant rats. A review.

1982 • 328 citations

Prostaglandins in Human Seminal Plasma

1966 • 324 citations

Isolation, complementary DNA sequence, and regulation of rat hepatic lauric acid omega-hydroxylase (cytochrome P-450LA omega). Identification of a new cytochrome P-450 gene family.

1987 • 317 citations

Liver microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid.

1981 • 295 citations

Molecular cloning of an allene oxide synthase: a cytochrome P450 specialized for the metabolism of fatty acid hydroperoxides.

1993 • 291 citations

Cytochrome P-450 Metabolism of Arachidonic Acid

1991 • 290 citations

Cytochrome P450 and the arachidonate cascade ¹

1992 • 288 citations

On the mechanism of prostacyclin and thromboxane A2 biosynthesis

1989 • 287 citations

Cytochrome P-450 metabolism of arachidonic acid: formation and biological actions of "epoxygenase"-derived eicosanoids.

1988 • 261 citations

Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates.

1982 • 251 citations

Properties of leukotriene B4 20-hydroxylase from polymorphonuclear leukocytes.

1984 • 236 citations

Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes.

1984 • 221 citations

Hepatic cytochromeP-450 monooxygenase system

1983 • 214 citations

Formation of 19(S)-, 19(R)-, and 18(R)-hydroxyeicosatetraenoic acids by alcohol-inducible cytochrome P450 2E1

1993 • 198 citations

Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet.

1994 • 190 citations

Stereochemical difference between 12-hydroxy-5,8,10,14-eicosatetraenoic acid in platelets and psoriatic lesions

1986 • 181 citations

Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450

1974 • 173 citations

Molecular Cloning, Expression and Characterization of an Endogenous Human Cytochrome P450 Arachidonic Acid Epoxygenase Isoform

1995 • 172 citations

Isolation of preferentially expressed genes in the kidneys of hypertensive rats.

1991 • 170 citations

Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension.

1990 • 169 citations

12(R)-hydroxyicosatetraenoic acid: a cytochrome-P450-dependent arachidonate metabolite that inhibits Na+,K+-ATPase in the cornea.

1987 • 166 citations

A novel leukotriene produced by stimulation of leukocytes with formylmethionylleucylphenylalanine.

1982 • 166 citations

Selective incorporation of (15S)-hydroxyeicosatetraenoic acid in phosphatidylinositol of human neutrophils: agonist-induced deacylation and transformation of stored hydroxyeicosanoids.

1990 • 164 citations

Metabolism of 20-hydroxyeicosatetraenoic acid by cyclooxygenase

1989 • 164 citations

Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading.

1992 • 151 citations

Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid

1982 • 147 citations

Cytochrome P-450-dependent oxygenation of arachidonic acid to hydroxyicosatetraenoic acids.

1982 • 147 citations

Oxygenation of polyunsaturated fatty acids by cytochrome P450 monooxygenates

1994 • 146 citations

Endogenous epoxyeicosatrienoyl-phospholipids. A novel class of cellular glycerolipids containing epoxidized arachidonate moieties.

1991 • 145 citations

Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase.

1990 • 143 citations

NOVEL HYPOTHALAMIC ARACHIDONATE PRODUCTS STIMULATE SOMATOSTATIN RELEASE FROM THE MEDIAN EMINENCE¹

1983 • 141 citations

The Rat Clofibrate-InducibleCYP4ASubfamily II. cDNA Sequence of IVA3, Mapping of theCyp4aLocus to Mouse Chromosome 4, and Coordinate and Tissue-Specific Regulation of theCYP4AGenes

1989 • 140 citations

12S,20-dihydroxyicosatetraenoic acid: a new icosanoid synthesized by neutrophils from 12S-hydroxyicosatetraenoic acid produced by thrombin- or collagen-stimulated platelets.

1984 • 139 citations

A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 omega-hydroxylase

1993 • 137 citations

Absolute configuration of the hydroxyeicosatetraenoic acids (HETEs) formed during catalytic oxygenation of arachidonic acid by microsomal cytochrome P-450

1986 • 134 citations

The oxidative metabolism of arachidonic acid by purified cytochromes P-450

1981 • 133 citations

Oxidation by Molecular Oxygen. II. The Oxygen Atom Transfer Mechanism for Mixed-Function Oxidases and the Model for Mixed-Function Oxidases

1964 • 130 citations

Isolation and molecular cloning of prostacyclin synthase from bovine endothelial cells.

1994 • 130 citations

Metabolism of arachidonate through NADPH-dependent oxygenase of renal cortex.

1981 • 129 citations

The Rat Clofibrate-InducibleCYP4AGene Subfamily I. Complete Intron and Exon Sequence of theCYP4A1andCYP4A2Genes, Unique Exon Organization, and Identification of a Conserved 19-bp Upstream Element

1989 • 122 citations

Molecular cloning of human platelet thromboxane a synthase

1991 • 116 citations

Arachidonic acid epoxygenase: Structural characterization and quantification of epoxyeicosatrienoates in plasma

1992 • 107 citations

Purification and biochemical characterization of two major cytochrome P-450 isoforms induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in chick embryo liver.

1994 • 103 citations

Biosynthesis of 19‐Hydroxy‐Prostaglandin A₁

1969 • 99 citations

Primary structure of human thromboxane synthase determined from the cDNA sequence.

1992 • 99 citations

Endogenous substrates of monooxygenases: Fatty acids and prostaglandins

1980 • 98 citations

Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase

1993 • 97 citations

Endogenous epoxyeicosatrienoic acids

1989 • 96 citations

Cytochrome P-450-dependent oxidation of arachidonic acid to 16-, 17-, and 18-hydroxyeicosatetraenoic acids.

1990 • 96 citations

12(R)-hydroxyeicosatrienoic acid: a vasodilator cytochrome P-450-dependent arachidonate metabolite from the bovine corneal epithelium.

1988 • 93 citations

cDNA cloning and inducible expression during pregnancy of the mRNA for rabbit pulmonary prostaglandin omega-hydroxylase (cytochrome P-450p-2).

1987 • 92 citations

Substitution of 15-hydroxyeicosatetraenoic acid in the phosphoinositide signaling pathway.

1991 • 88 citations

Complete cDNA Sequence and cDNA-Directed Expression of CYP4A11, a Fatty Acid ω-Hydroxylase Expressed in Human Kidney

1993 • 80 citations

Omega-hydroxylation of 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid in human polymorphonuclear leukocytes.

1984 • 79 citations

Oxygenation of arachidonic acid by hepatic microsomes of the rabbit

1981 • 78 citations

Expression of Rabbit Cytochromes P4504A Which Catalyze the ω-Hydroxylation of Arachidonic Acid, Fatty Acids, and Prostaglandins

1993 • 76 citations

Characterization of a cDNA encoding a human kidney, cytochrome 4A fatty acid ω-hydroxylase and the cognate enzyme expressed in Escherichia coli

1993 • 75 citations

Incorporation and distribution of epoxyeicosatrienoic acids into cellular phospholipids.

1992 • 70 citations

Arachidonic acid epoxygenase

1990 • 70 citations

Cloning and expression of three rabbit kidney cDNAs encoding lauric acid .omega.-hydroxylases

1990 • 66 citations

Arachidonic acid epoxidation: Epoxyeicosatrienoic acids are endogenous constituents of rat liver

1984 • 66 citations

Role of hepatic and renal cytochrome p-450 iva1 in the metabolism of lipid substrates

1989 • 65 citations

20-Hydroxyeicosatetraenoic acid is excreted as a glucuronide conjugate in human urine

1992 • 64 citations

Biochemical characterization of hepatic microsomal leukotriene B4 hydroxylases.

1987 • 62 citations

Cloning and Characterization of a Novel Member of the Cytochrome P450 Subfamily IVA in Rat Prostate

1990 • 60 citations

Two Forms of ω-Hydroxylase Toward Prostaglandin A and Laurate

1989 • 60 citations

5,6-epoxyeicosatrienoic acid, a novel arachidonate metabolite. Mechanism of vasoactivity in the rat.

1990 • 57 citations

The effects of unsaturated fatty acids on hepatic microsomal drug metabolism and cytochrome P-450

1969 • 56 citations

Characterization of human neutrophil leukotriene B₄ω‐hydroxylase as a system involving a unique cytochrome P‐450 and NADPH–cytochrome P‐450 reductase

1988 • 55 citations

Characterization of three cytochrome P450s purified from renal microsomes of untreated male rats and comparison with human renal cytochrome P450

1990 • 55 citations

Role of Cytochrome P-450 in Elevating Renal Vascular Tone in Spontaneously Hypertensive Rats

1993 • 55 citations

Stereochemical requirements for substrate specificity of LTB4 20-hydroxylase.

1987 • 54 citations

Quantitative and mechanistic aspects of the hydroperoxide‐induced release of Ca²⁺ from rat liver mitochondria

1985 • 52 citations

Catalytic properties of rabbit kidney fatty acid omega-hydroxylase cytochrome P-450ka2 (CYP4A7).

1993 • 51 citations

Influence of a fibric acid type of hypolipidemic agent on the oxidative metabolism of arachidonic acid by liver microsomal cytochrome P-450

1985 • 49 citations

Biosynthesis of 18(RD)-hydroxyeicosatetraenoic acid from arachidonic acid by microsomes of monkey seminal vesicles

1989 • 46 citations

Regiospecific and enantioselective metabolism of 8,9-epoxyeicosatrienoic acid by cyclooxygenase

1992 • 45 citations

Transformation of an arachidonic acid hydroperoxide into epoxyhydroxy and trihydroxy fatty acids by liver microsomal cytochrome P-450

1987 • 44 citations

5-Hydroxyicosatetraenoate promotes Ca2+ and protein kinase C mobilization in neutrophils

1987 • 43 citations

Auto-oxidation-induced fusion of lipid vesicles

1982 • 43 citations

Renal Microsomal Cytochrome P-450 and the Oxidative Metabolism of Arachidonic Acid**A preliminary report of parts of this work was presented at the 18th Annual Meeting of the American Society of Nephrology in New Orleans, Louisiana, December 1985.

1988 • 41 citations

bis-Allylic hydroxylation of linoleic acid and arachidonic acid by human hepatic monooxygenases

1993 • 40 citations

Platelet cytochrome P-450: A possible role in arachidonate-induced aggregation

1976 • 40 citations

cDNA cloning and expression of the mRNA for cytochrome P‐450_kd which shows a fatty acid ω‐hydroxylating activity

1991 • 36 citations

Hormonal Regulation of Cytochrome P-450 Gene Expression

1991 • 33 citations

NADPH-dependent microsomal metabolism of 14,15-epoxyeicosatrienoic acid to diepoxides and epoxyalcohols

1988 • 33 citations

Purification and NH2-terminal amino acid sequences of human and rat kidney fatty acid ω-hydroxylases

1992 • 33 citations

Metabolism of 5(6)-expoxyeicosatrienoic acid by ram seminal vesicles

1984 • 29 citations

Cytochrome P450-Dependent Arachidonic Acid Metabolites, 19− and 20-Hydroxyeicosatetraenoic Acids, Enhance Sodium-Potassium ATPase Activity in Vascular Smooth Muscle

1990 • 29 citations

ω-Hydroxylation of lipoxin B4 by human neutrophil microsomes: Identification of ω-hydroxy metabolite of lipoxin B4 and catalysis by leukotriene B4 ω-hydroxylase (cytochrome P-450LTBω)

1993 • 28 citations

Analysis of the catalytic specificity of cytochrome P450 enzymes through site‐directed mutagenesis

1992 • 26 citations

Inhibition of hepatic drug-metabolizing enzymes by arachidonic acid

1979 • 24 citations

omega-Hydroxylation of 15-hydroxyeicosatetraenoic acid by lung microsomes from pregnant rabbits.

1987 • 23 citations

Biosynthesis of 12(S)‐hydroxyeicosatetraenoic acid by bovine corneal epithelium

1993 • 23 citations

Stereoselective epoxidation of arachidonic acid by cytochrome P-450s 2CAA and 2C2.

1994 • 22 citations

Detection of 20-hydroxyeicosatetrenoic acid in rat urine

1991 • 21 citations

Metabolism of lipoxins A4 and B4 and of their all-trans isomers by human leukocytes and rat liver microsomes

1991 • 18 citations

Epoxidation of prostacyclin in the rabbit kidney.

1985 • 14 citations

Metabolism of 12(R)-hydroxyeicosatetraenoic acid by rat liver microsomes

1992 • 12 citations

Cytochrome P-450 Epoxygenase Dependent Formation of Novel Endogenous Epoxyeicosatrienoyl-Phospholipids

1993 • 7 citations