Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

ARACHIDONIC ACID METABOLISM

1986 • 1,802 citations

P450 GENES: STRUCTURE, EVOLUTION, AND REGULATION

1987 • 1,559 citations

The molecular biology of cytochrome P450s.

1988 • 1,294 citations

Liver microsomal cytochrome P-450 and the oxidative metabolism of arachidonic acid.

1981 • 295 citations

Cytochrome P-450 Metabolism of Arachidonic Acid

1991 • 290 citations

Cytochrome P450 and the arachidonate cascade ¹

1992 • 288 citations

Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction.

1986 • 258 citations

A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence.

1990 • 247 citations

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily

1991 • 200 citations

The reaction of arachidonic acid epoxides (epoxyeicosatrienoic acids) with a cytosolic epoxide hydrolase

1983 • 190 citations

Isolation of preferentially expressed genes in the kidneys of hypertensive rats.

1991 • 170 citations

Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension.

1990 • 169 citations

Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading.

1992 • 151 citations

Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase.

1990 • 143 citations

Prostaglandins and Membrane Ion Transport

1984 • 130 citations

Metabolism of arachidonate through NADPH-dependent oxygenase of renal cortex.

1981 • 129 citations

Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin and phenobarbital on the occurrence and distribution of four cytochrome P-450 isozymes in rabbit kidney, lung, and liver.

1982 • 128 citations

Angiotensin II stimulates phospholipases C and A2 in cultured rat mesangial cells

1987 • 114 citations

[43] Cytochrome P-450 arachidonate oxygenase

1990 • 92 citations

Oxygenation of arachidonic acid by hepatic microsomes of the rabbit

1981 • 78 citations

Cytochrome P450 metabolites of arachidonic acid are potent inhibitors of vasopressin action on rabbit cortical collecting duct.

1989 • 66 citations

[24] Rat hepatic P450IIA and P450IIC subfamily expression using catalytic, immunochemical, and molecular probes

1991 • 63 citations

Resolution of epoxyeicosatrienoate enantiomers by chiral phase chromatography

1989 • 54 citations

CYTOCHROME P-450 MONOOXYGENASE SYSTEM IN THE RABBIT KIDNEY: ITS INTRANEPHRON LOCALIZATION AND ITS INDUCTION

1983 • 53 citations

Purification and properties of a cytochrome P450 arachidonic acid epoxygenase from rabbit renal cortex.

1992 • 50 citations

Biochemistry and pharmacology of renal arachidonic acid metabolism

1986 • 44 citations

[10] Heterologous expression of mammalian P450 in COS cells

1991 • 38 citations

Blockade by lithium ions of potassium channels in rat anterior pituitary cells

1991 • 23 citations

Isolation and partial characterization of the gene for cytochrome P-450 3a (P-450ALC) and a second closely related gene

1988 • 14 citations

Inhibition of epoxide metabolism by α,β-epoxyketones and isosteric analogs

1985 • 13 citations

cDNA and deduced amino acid sequence of a novel cytochrome P-450 from female rat liver mRNA with high homology to P-450 IIC family

1990 • 11 citations

CYTOCHROME P-450 MONOOXYGENASE SYSTEM IN THE RABBIT KIDNEY: ITS INTRANEPHRON LOCALIZATION AND ITS INDUCTION*

1983 • 10 citations