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Genetic modulation of hypoxia induced gene expression and angiogenesis relevance to brain tumors

Data up to Jan 2025

Published2003
Citations74
References108

Total Citations Per Year

Abstract

References (108)

Angiogenesis in cancer and other diseases

2000 • 8,734 citations

Cell Signaling by Receptor Tyrosine Kinases

2010 • 7,477 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1999 • 4,973 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

The Biology of Vascular Endothelial Growth Factor

1997 • 4,359 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Vascular-specific growth factors and blood vessel formation

2000 • 3,667 citations

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

2001 • 3,215 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1999 • 1,972 citations

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

2002 • 1,512 citations

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

2002 • 1,472 citations

Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

1994 • 1,460 citations

Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.

2000 • 1,430 citations

FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity

2001 • 1,326 citations

HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression

2001 • 1,230 citations

The Biology of Vascular Endothelial Growth Factor

1997 • 1,203 citations

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

2000 • 1,087 citations

Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1

1996 • 1,081 citations

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth

1997 • 1,059 citations

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration

2001 • 1,012 citations

Tumor angiogenesis: past, present and the near future

2000 • 973 citations

Tumor Induction of VEGF Promoter Activity in Stromal Cells

1998 • 964 citations

The splice variants of vascular endothelial growth factor (VEGF) and their receptors

2001 • 943 citations

Nucleolar Arf sequesters Mdm2 and activates p53

1999 • 937 citations

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo

1998 • 933 citations

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

2001 • 917 citations

HIF-1 and human disease: one highly involved factor

2000 • 900 citations

Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function

1999 • 834 citations

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo

1998 • 828 citations

Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies.

2000 • 750 citations

Regulation of angiogenesis via vascular endothelial growth factor receptors.

2000 • 749 citations

Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway

1999 • 744 citations

Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family

2002 • 698 citations

Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops.

1992 • 689 citations

Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas.

2000 • 667 citations

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

2001 • 666 citations

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha

1998 • 653 citations

Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo.

1991 • 634 citations

Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation

1995 • 603 citations

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

1993 • 565 citations

Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1.

2001 • 550 citations

Combination bacteriolytic therapy for the treatment of experimental tumors

2001 • 532 citations

Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

2000 • 529 citations

Insulin Stimulates Hypoxia-inducible Factor 1 through a Phosphatidylinositol 3-Kinase/Target of Rapamycin-dependent Signaling Pathway

2002 • 527 citations

V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression.

1997 • 526 citations

Suppression of tumor growth through disruption of hypoxia-inducible transcription

2000 • 501 citations

Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells Through a Hypoxia Inducible Factor-1 Transcriptional Element

1997 • 501 citations

Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways

1997 • 470 citations

Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway.

2002 • 448 citations

CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.

1994 • 439 citations

Heterogeneity of the Angiogenic Response Induced in Different Normal Adult Tissues by Vascular Permeability Factor/Vascular Endothelial Growth Factor

2000 • 421 citations

In VivoExpression of mRNAs Encoding Hypoxia-Inducible Factor 1

1996 • 412 citations

Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression.

1995 • 409 citations

Activation of the HIF pathway in cancer

2001 • 403 citations

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

1999 • 387 citations

Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors.

1992 • 380 citations

Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

2000 • 368 citations

Mechanisms of Angiogenesis in the Brain

1999 • 352 citations

Regulation of p53 by Hypoxia: Dissociation of Transcriptional Repression and Apoptosis from p53-Dependent Transactivation

2001 • 347 citations

Concentration of vascular endothelial growth factor in the serum and tumor tissue of brain tumor patients.

1996 • 337 citations

Subsets of Glioblastoma Multiforme Defined by Molecular Genetic Analysis

1993 • 334 citations

Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas.

1995 • 329 citations

Analysis of the p53 gene and its expression in human glioblastoma cells.

1994 • 329 citations

Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells

1994 • 315 citations

Hypoxia Links ATR and p53 through Replication Arrest

2002 • 309 citations

Transcriptional Response to Hypoxia in Human Tumors

2001 • 300 citations

Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia.

2000 • 298 citations

Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells.

2002 • 296 citations

A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis

1997 • 285 citations

p53 Inhibits Hypoxia-inducible Factor-stimulated Transcription

1998 • 284 citations

Gene expression of fibroblast growth factors in human gliomas and meningiomas: demonstration of cellular source of basic fibroblast growth factor mRNA and peptide in tumor tissues.

1990 • 279 citations

Upregulation of Interleukin 8 by Oxygen-deprived Cells in Glioblastoma Suggests a Role in Leukocyte Activation, Chemotaxis, and Angiogenesis

1997 • 244 citations

Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer.

1998 • 242 citations

Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression.

1996 • 240 citations

The von Hippel–Lindau tumor suppressor protein

2001 • 208 citations

Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia-driven mechanisms.

1997 • 196 citations

Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase.

1999 • 191 citations

Pathology and Genetics of Tumours of the Nervous System

2000 • 185 citations

Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivation.

2001 • 175 citations

Induction of Hypoxia-Inducible Factor-1, Erythropoietin, Vascular Endothelial Growth Factor, and Glucose Transporter-1 by Hypoxia: Evidence Against a Regulatory Role for Src Kinase

1997 • 175 citations

Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA.

1997 • 174 citations

Thrombospondins and tumor angiogenesis

2001 • 173 citations

VPF/VEGF and the angiogenic response

2000 • 150 citations

p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma

2000 • 149 citations

Inhibition of angiogenesis in human glioblastomas by chromosome 10 induction of thrombospondin-1.

1996 • 145 citations

Early and Extensive Contribution of Pericytes/Vascular Smooth Muscle Cells to Microvascular Proliferation in Glioblastoma Multiforme

1995 • 145 citations

Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells.

1994 • 145 citations

Glomeruloid Microvascular Proliferation Orchestrated by VPF/VEGF

2001 • 143 citations

Early Growth Response-1 gene mediates up-regulation of epidermal growth factor receptor expression during hypoxia.

2002 • 139 citations

Restoration of wild-type p16 down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human gliomas.

1999 • 131 citations

Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma

1999 • 116 citations

Up-Regulation of Vascular Endothelial Growth Factor in Stromal Cells of Hemangioblastomas Is Correlated with Up-Regulation of the Transcription Factor HRF/HIF-2α

1998 • 115 citations

Generation of bidirectional hypoxia/HIF-responsive expression vectors to target gene expression to hypoxic cells

2001 • 113 citations

Thrombospondin-1 Is Downregulated by Anoxia and Suppresses Tumorigenicity of Human Glioblastoma Cells

2000 • 110 citations

The p14ARF Tumor Suppressor Protein Facilitates Nucleolar Sequestration of Hypoxia-inducible Factor-1α (HIF-1α) and Inhibits HIF-1-mediated Transcription

2001 • 110 citations

Cytokines and tumors of the central nervous system

1995 • 100 citations

Vascular endothelial growth factor isoforms display distinct activities in promoting tumor angiogenesis at different anatomic sites.

2001 • 95 citations

Mutant epidermal growth factor receptor enhances induction of vascular endothelial growth factor by hypoxia and insulin-like growth factor-1 via a PI3 kinase dependent pathway

2001 • 90 citations

Repression of alpha-fetoprotein gene expression under hypoxic conditions in human hepatoma cells: characterization of a negative hypoxia response element that mediates opposite effects of hypoxia inducible factor-1 and c-Myc.

2002 • 89 citations

p53 and Brain Tumors: From Gene Mutations to Gene Therapy

1998 • 82 citations

Up-regulation of hypoxia-inducible factor-1alpha is not sufficient for hypoxic/anoxic p53 induction.

1998 • 79 citations

Tumors of the Central Nervous System

1994 • 53 citations

Genetic instability leads to loss of both p53 alleles in a human glioblastoma

1998 • 44 citations

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Genetic modulation of hypoxia induced gene expression and angiogenesis relevance to brain… (2003) – Frontiers in bioscience | Metascience Observatory Explorer