Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas.

Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors

1998 • 4,380 citations

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A

1993 • 1,941 citations

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

1985 • 1,523 citations

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

1997 • 1,508 citations

A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity.

1994 • 932 citations

Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder.

1995 • 895 citations

Structural alterations of the epidermal growth factor receptor gene in human gliomas.

1992 • 853 citations

Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.

1987 • 843 citations

Activation of RET as a Dominant Transforming Gene by Germline Mutations of MEN2A and MEN2B

1995 • 826 citations

Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo.

1991 • 634 citations

Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails.

1992 • 609 citations

Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas.

1990 • 593 citations

Single missense mutation in the tyrosine kinasecatalytic domain of the RET protooncogene is associated with multiple endocrineneoplasia type 2B.

1994 • 591 citations

Clonal genomic alterations in glioma malignancy stages.

1988 • 520 citations

Activating mutations for the Met tyrosine kinase receptor in human cancer

1997 • 441 citations

Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation

1989 • 356 citations

Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene.

1995 • 278 citations

Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts.

1988 • 259 citations

Functional characterization of an EGF receptor with a truncated extracellular domain expressed in glioblastomas with EGFR gene amplification.

1994 • 255 citations

Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors.

1988 • 218 citations

Transformational and altered signal transduction by a naturally occurring mutant EGF receptor.

1996 • 195 citations

Activating mutations in the extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domain

1998 • 168 citations

Selective amplification of the cytoplasmic domain of the epidermal growth factor receptor gene in glioblastoma multiforme.

1988 • 157 citations

Deletion-mutant epidermal growth factor receptor in human gliomas: Effect of type II mutation on receptor function

1991 • 101 citations

Gene amplification as a prognostic factor in primary and secondary high-grade malignant gliomas.

1998 • 80 citations

Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type I.

1998 • 74 citations

Expression of an altered epidermal growth factor receptor by human glioblastoma cells.

1988 • 68 citations

Enhanced tumorigenesis of NR6 cells which express non-down-regulating epidermal growth factor receptors.

1991 • 53 citations

A complete description of the EGF-receptor exon structure: implication in oncogenic activation and domain evolution.

1993 • 39 citations

Tandem duplication of the epidermal growth factor receptor tyrosine kinase and calcium internalization domains in A-172 glioma cells

1998 • 37 citations

Epidermal growth factor (EGF)-stimulated tyrosine phosphorylation and EGF receptor degradation in cells expressing EGF receptors truncated at residue 973.

1992 • 35 citations

Analysis of EGF receptor amplicons reveals amplification of multiple expressed sequences

1998 • 29 citations

3′ End structure and rearrangements ofEGFR in glioblastomas

1998 • 17 citations