Transcription regulation in eukaryotes

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

Chromatin Structure: A Repeating Unit of Histones and DNA

1974 • 2,514 citations

Atomic structure of the actin: DNase I complex

1990 • 1,897 citations

Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation

1997 • 1,814 citations

Histone acetylation and transcriptional regulatory mechanisms

1998 • 1,793 citations

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

1996 • 1,769 citations

Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation

1996 • 1,567 citations

Roles of histone acetyltransferases and deacetylases in gene regulation

1998 • 1,207 citations

Transcriptional activation by recruitment

1997 • 1,163 citations

ALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION

1998 • 1,124 citations

A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II

1994 • 1,064 citations

Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.

1997 • 1,053 citations

Mechanism of transcriptional activation by Sp1: Evidence for coactivators

1990 • 1,029 citations

Structure of the nucleosome core particle at 7 Å resolution

1984 • 1,028 citations

Stimulation of GAL4 Derivative Binding to Nucleosomal DNA by the Yeast SWI/SNF Complex

1994 • 853 citations

DNA Repair Helicase: a Component of BTF2 (TFIIH) Basic Transcription Factor

1993 • 795 citations

Crystal structure of globular domain of histone H5 and its implications for nucleosome binding

1993 • 739 citations

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex

1999 • 733 citations

BIOCHEMISTRY AND STRUCTURAL BIOLOGY OF TRANSCRIPTION FACTOR IID (TFIID)

1996 • 721 citations

Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation

1991 • 711 citations

Ordered Recruitment of Transcription and Chromatin Remodeling Factors to a Cell Cycle– and Developmentally Regulated Promoter

1999 • 703 citations

Phosphorylation of Histone H3 Is Required for Proper Chromosome Condensation and Segregation

1999 • 701 citations

The structure of histone H1 and its location in chromatin

1980 • 696 citations

RSC, an Essential, Abundant Chromatin-Remodeling Complex

1996 • 680 citations

The Novel ATM-Related Protein TRRAP Is an Essential Cofactor for the c-Myc and E2F Oncoproteins

1998 • 675 citations

ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor

1994 • 662 citations

ACF, an ISWI-Containing and ATP-Utilizing Chromatin Assembly and Remodeling Factor

1997 • 624 citations

Reconstitution of a Core Chromatin Remodeling Complex from SWI/SNF Subunits

1999 • 608 citations

Co-activators and co-repressors in the integration of transcriptional responses

1998 • 606 citations

Purification and properties of an ATP-dependent nucleosome remodeling factor

1995 • 600 citations

Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators

1993 • 589 citations

Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection

1992 • 567 citations

Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex.

1996 • 556 citations

Repression by Ume6 Involves Recruitment of a Complex Containing Sin3 Corepressor and Rpd3 Histone Deacetylase to Target Promoters

1997 • 546 citations

Histone-like TAFs within the PCAF Histone Acetylase Complex

1998 • 534 citations

Chromatin-remodelling factor CHRAC contains the ATPases ISWI and topoisomerase II

1997 • 511 citations

Eukaryotic RNA Polymerase

1985 • 500 citations

Elongator, a Multisubunit Component of a Novel RNA Polymerase II Holoenzyme for Transcriptional Elongation

1999 • 482 citations

Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors

1991 • 468 citations

A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast

1993 • 465 citations

The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion

1998 • 454 citations

A novel mediator between activator proteins and the RNA polymerase II transcription apparatus

1990 • 450 citations

Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo

1998 • 444 citations

GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein

1997 • 437 citations

The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor

1994 • 432 citations

Composite co-activator ARC mediates chromatin-directed transcriptional activation

1999 • 429 citations

Identity between TRAP and SMCC Complexes Indicates Novel Pathways for the Function of Nuclear Receptors and Diverse Mammalian Activators

1999 • 421 citations

Drosophila TFIID binds to a conserved downstream basal promoter element that is present in many TATA-box-deficient promoters.

1996 • 406 citations

Phosphorylation of histone H3 at serine 10 is correlated with chromosome condensation during mitosis and meiosis in Tetrahymena

1998 • 406 citations

A multisubunit complex containing the SWI1/ADR6,SWI2/SNF2, SWI3, SNF5, and SNF6 gene products isolated fromyeast.

1994 • 396 citations

A novel protein complex that interacts with the vitamin D₃ receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system

1998 • 391 citations

ISWI, a member of the SWl2/SNF2 ATPase family, encodes the 140 kDa subunit of the nucleosome remodeling factor

1995 • 366 citations

Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes

1994 • 361 citations

Functional Organization of the Yeast SAGA Complex: Distinct Components Involved in Structural Integrity, Nucleosome Acetylation, and TATA-Binding Protein Interaction

1999 • 358 citations

Nucleosome Movement by CHRAC and ISWI without Disruption or trans-Displacement of the Histone Octamer

1999 • 357 citations

The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1

1999 • 350 citations

TAFs mediate transcriptional activation and promoter selectivity

1996 • 334 citations

ATP-Dependent Histone Octamer Sliding Mediated by the Chromatin Remodeling Complex NURF

1999 • 334 citations

Regulation of PHO4 Nuclear Localization by the PHO80-PHO85 Cyclin-CDK Complex

1996 • 326 citations

Targeted Recruitment of the Sin3-Rpd3 Histone Deacetylase Complex Generates a Highly Localized Domain of Repressed Chromatin In Vivo

1998 • 319 citations

Activation of class II gene transcription by regulatory factors is potentiated by a novel activity

1991 • 318 citations

Stimulation of RARα Activation Function AF-1 through Binding to the General Transcription Factor TFIIH and Phosphorylation by CDK7

1997 • 307 citations

Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways

1998 • 305 citations

The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain

1998 • 299 citations

Reconstitution of the Transcription Factor TFIIH

1999 • 296 citations

Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein

1999 • 291 citations

Histone Octamer Transfer by a Chromatin-Remodeling Complex

1999 • 290 citations

Messenger RNA synthesis in mammalian cells is catalyzed by the phosphorylated form of RNA polymerase II.

1987 • 288 citations

Human SWI/SNF Interconverts a Nucleosome between Its Base State and a Stable Remodeled State

1998 • 283 citations

A Novel Human SRB/MED-Containing Cofactor Complex, SMCC, Involved in Transcription Regulation

1999 • 276 citations

Conserved Structures of Mediator and RNA Polymerase II Holoenzyme

1999 • 272 citations

Contact with a component of the polymerase II holoenzyme suffices for gene activation

1995 • 262 citations

Structural similarity between TAFs and the heterotetrameric core of the histone octamer

1996 • 258 citations

Mitotic inactivation of a human SWI/SNF chromatin remodeling complex

1998 • 257 citations

6-Azauracil inhibition of GTP biosynthesis in Saccharomyces cerevisiae

1992 • 254 citations

Targeted insertion of exogenous DNA into the eukaryotic genome by the Cre recombinase.

1990 • 253 citations

Function of TAFII-containing complex without TBP in transcription by RNA polymerase II

1998 • 252 citations

Topology and reorganization of a human TFIID–promoter complex

1996 • 247 citations

Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme.

1995 • 247 citations

Transcription activation in cells lacking TAFIIs

1996 • 238 citations

ISWI Is an ATP-Dependent Nucleosome Remodeling Factor

1999 • 237 citations

Enhancement of TBP binding by activators and general transcription factors

1999 • 237 citations

NAT, a Human Complex Containing Srb Polypeptides that Functions as a Negative Regulator of Activated Transcription

1998 • 235 citations

An Asymmetric Model for the Nucleosome: A Binding Site for Linker Histones Inside the DNA Gyres

1996 • 233 citations

Position and orientation of the globular domain of linker histone H5 on the nucleosome

1998 • 232 citations

Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo

1998 • 230 citations

The multiple roles of transcription/repair factor TFIIH

1996 • 227 citations

Depletion of histone H4 and nucleosomes activates the PHO5 gene in Saccharomyces cerevisiae.

1988 • 226 citations

Contacts in Context: Promoter Specificity and Macromolecular Interactions in Transcription

1996 • 223 citations

Linking histone acetylation to transcriptional regulation

1998 • 222 citations

Two Functionally Distinct Forms of the RSC Nucleosome-Remodeling Complex, Containing Essential AT Hook, BAH, and Bromodomains

1999 • 216 citations

Drosophila TAF _II 150: Similarity to Yeast Gene TSM-1 and Specific Binding to Core Promoter DNA

1994 • 212 citations

Unique TATA-binding protein-containing complexes and cofactors involved in transcription by RNA polymerases II and III.

1993 • 206 citations

Mechanism of Transcription Through the Nucleosome by Eukaryotic RNA Polymerase

1997 • 205 citations

Purification and interaction properties of the human RNA polymerase B(II) general transcription factor BTF2.

1991 • 202 citations

Activated RSC–Nucleosome Complex and Persistently Altered Form of the Nucleosome

1998 • 198 citations

RNA Polymerase II Holoenzymes and Subcomplexes

1998 • 197 citations

Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH

1997 • 195 citations

Facilitated Recycling Pathway for RNA Polymerase III

1996 • 188 citations

Mutations in XPB and XPD helicases found in xeroderma pigmentosum patients impair the transcription function of TFIIH

1999 • 188 citations

Participation of the TATA Factor in Transcription of the Yeast U6 Gene by RNA Polymerase C

1991 • 185 citations

Identification of TATA-binding Protein-free TAFII-containing Complex Subunits Suggests a Role in Nucleosome Acetylation and Signal Transduction

1999 • 181 citations

Yeast TAFII145 Functions as a Core Promoter Selectivity Factor, Not a General Coactivator

1997 • 179 citations

Role of General and Gene-specific Cofactors in the Regulation of Eukaryotic Transcription

1998 • 177 citations

Mapping nucleosome position at single base-pair resolution by using site-directed hydroxyl radicals.

1996 • 175 citations

Chromatin remodeling machines: similar motors, ulterior motives

1998 • 175 citations

Transcription factors vs nucleosomes: regulation of the PH05 promoter in yeast

1997 • 173 citations

Thyroid hormone receptor-associated proteins and general positive cofactors mediate thyroid hormone receptor function in the absence of the TATA box-binding protein-associated factors of TFIID

1999 • 167 citations

Human cyclin-dependent kinase-activating kinase exists in three distinct complexes.

1996 • 164 citations

Yeast TAF IIS in a multisubunit complex required for activated transcription

1994 • 163 citations

TFIIH: a key component in multiple DNA transactions

1996 • 160 citations

A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains.

1996 • 158 citations

Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation.

1997 • 155 citations

Activation Domain-Specific and General Transcription Stimulation by Native Histone Acetyltransferase Complexes

1999 • 155 citations

Human TAFII28 and TAFII18 Interact through a Histone Fold Encoded by Atypical Evolutionary Conserved Motifs Also Found in the SPT3 Family

1998 • 151 citations

Identification of two DNA-binding sites on the globular domain of histone H5.

1996 • 150 citations

A protein–protein interaction map of yeast RNA polymerase III

1999 • 147 citations

GAL11 protein, an auxiliary transcription activator for genes encoding galactose-metabolizing enzymes in Saccharomyces cerevisiae.

1988 • 145 citations

Yeast TAFII145 Required for Transcription of G1/S Cyclin Genes and Regulated by the Cellular Growth State

1997 • 143 citations

Positioning and stability of nucleosomes on MMTV 3′LTR sequences

1998 • 133 citations

Human TFIIIC Relieves Chromatin-Mediated Repression of RNA Polymerase III Transcription and Contains an Intrinsic Histone Acetyltransferase Activity

1999 • 133 citations

RNA Polymerase II Holoenzyme Recruitment Is Sufficient to Remodel Chromatin at the Yeast PHO5 Promoter

1997 • 133 citations

Mitogen-Activated Protein Kinase

1996 • 132 citations

Yeast RNA Polymerase II at 5 Å Resolution

1999 • 130 citations

Role of Nucleosome Remodeling Factor NURF in Transcriptional Activation of Chromatin

1997 • 129 citations

Identification and characterization of a TFIID-like multiprotein complex from Saccharomyces cerevisiae.

1995 • 126 citations

Evidence for a mediator cycle at the initiation of transcription

1997 • 126 citations

Structural and Functional Requirements for the Chromatin Transition at the PHO5 Promoter in Saccharomyces cerevisiae upon PHO5 Activation

1993 • 123 citations

Absence of Gcn5 HAT Activity Defines a Novel State in the Opening of Chromatin at the PHO5 Promoter in Yeast

1998 • 121 citations

A dynamic model for PC4 coactivator function in RNA polymerase II transcription

1998 • 121 citations

The transactivation domain of Pho4 is required for nucleosome disruption at the PHO5 promoter.

1994 • 121 citations

Activator-Mediated Recruitment of the RNA Polymerase II Machinery Is the Predominant Mechanism for Transcriptional Activation in Yeast

1998 • 118 citations

Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation.

1995 • 116 citations

Conserved Residues of Human XPG Protein Important for Nuclease Activity and Function in Nucleotide Excision Repair

1999 • 114 citations

The coactivator p15 (PC4) initiates transcriptional activation during TFIIA-TFIID-promoter complex formation.

1995 • 113 citations

Transcription units as RNA processing units

1997 • 110 citations

The Histone H3–like TAF Is Broadly Required for Transcription in Yeast

1998 • 109 citations

Global Transcription Regulators of Eukaryotes

1999 • 106 citations

The human general co-factors

1996 • 105 citations

Dual role of the C34 subunit of RNA polymerase III in transcription initiation

1997 • 103 citations

TTF-I determines the chromatin architecture of the active rDNA promoter

1998 • 102 citations

The Saccharomyces cerevisiae SPT13/GAL11 gene has both positive and negative regulatory roles in transcription.

1989 • 101 citations

The transcription factor, the Cdk, its cyclin and their regulator: directing the transcriptional response to a nutritional signal.

1994 • 100 citations

Activated transcription independent of the RNA polymerase II holoenzyme in budding yeast

1998 • 99 citations

Mammalian TAFII30 is required for cell cycle progression and specific cellular differentiation programmes

1999 • 96 citations

Homo- and Heteronuclear Two-Dimensional NMR Studies of the Globular Domain of Histone H1: Full Assignment, Tertiary Structure, and Comparison with the Globular Domain of Histone H5

1994 • 96 citations

Transcription of ribosomal RNA genes by eukaryotic RNA polymerase I

1998 • 95 citations

Transcriptional activation independent of TFIIH kinase and the RNA polymerase II mediator in vivo

1998 • 95 citations

DNA Topoisomerase I and PC4 Can Interact with Human TFIIIC to Promote Both Accurate Termination and Transcription Reinitiation by RNA Polymerase III

1998 • 93 citations

The TATA box binding protein

1996 • 90 citations

Mechanisms of transcription complex assembly

1996 • 89 citations

A suppressor of mutations in the class III transcription system encodes a component of yeast TFIIIB.

1996 • 88 citations

A 3′→ 5′ XPB Helicase Defect in Repair/Transcription Factor TFIIH of Xeroderma Pigmentosum Group B Affects Both DNA Repair and Transcription

1996 • 88 citations

Complex Interactions between Yeast TFIIIB and TFIIIC

1995 • 87 citations

Nicking-closing enzyme assembles nucleosome-like structures in vitro.

1979 • 85 citations

Electron Crystal Structure of an RNA Polymerase II Transcription Elongation Complex

1999 • 84 citations

Role of Histone H1 as an Architectural Determinant of Chromatin Structure and as a Specific Repressor of Transcription onXenopus Oocyte 5S rRNA Genes

1998 • 82 citations

In vitro chromatin remodelling by chromatin accessibility complex (CHRAC) at the SV40 origin of DNA replication

1998 • 80 citations

Inorganic pyrophosphatase is a component of theDrosophilanucleosome remodeling factor complex

1998 • 78 citations

Site-Directed Cleavage of DNA by a Linker Histone−Fe(II) EDTA Conjugate: Localization of a Globular Domain Binding Site within a Nucleosome

1996 • 77 citations

Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH

1997 • 74 citations

Location and function of linker histones

1998 • 70 citations

RNA polymerase switch in transcription of yeast rDNA: Role of transcription factor UAF (upstream activation factor) in silencing rDNA transcription by RNA polymerase II

1999 • 67 citations

A novel mutation that affects utilization of galactose in Saccharomyces cerevisiae

1980 • 66 citations

Differential nucleosome positioning on Xenopus oocyte and somatic 5 s RNA genes determines both TFIIIA and H1 binding: a mechanism for selective H1 repression 1 1Edited by J. Karn

1998 • 61 citations

A post-recruitment function for the RNA polymerase III transcription–initiation factor IIIB

1998 • 60 citations

Reciprocal interferences between nucleosomal organization and transcriptional activity of the yeast SNR6 gene.

1995 • 59 citations

Transcriptional activation by artificial recruitment in yeast is influenced by promoter architecture and downstream sequences

1999 • 58 citations

Regulatory targets in the RNA polymerase II holoenzyme

1998 • 54 citations

Life with nucleosomes: chromatin remodelling in gene regulation

1998 • 43 citations

Transcription Factors and Human Disease

1998 • 40 citations

Formation and Crystallization of Yeast RNA Polymerase II Elongation Complexes

1997 • 40 citations

Nucleosome Translational Position, Not Histone Acetylation, Determines TFIIIA Binding to Nucleosomal Xenopus laevis 5S rRNA Genes

1998 • 35 citations

Nucleosome Motion: Evidence and Models

1985 • 32 citations

Neutron scattering studies of chromatosomes

1991 • 28 citations

Molecular Cloning of DNAs Encoding the Regulatory Subunits of Elongin fromSaccharomyces cerevisiaeandDrosophila melanogaster

1997 • 22 citations

Promoter Structure-dependent Functioning of the General Transcription Factor IIE in Saccharomyces cerevisiae

1997 • 22 citations

Functional Correlation among Gal11, Transcription Factor (TF) IIE, and TFIIH in Saccharomyces cerevisiae

1998 • 17 citations

Activator-Specific Requirement for the General Transcription Factor IIE in Yeast

1999 • 16 citations

Yeast Gal11 and Transcription Factor IIE Function through a Common Pathway in Transcriptional Regulation

1997 • 15 citations