Linking histone acetylation to transcriptional regulation

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS

1964 • 2,410 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

1996 • 1,769 citations

AIB1, a Steroid Receptor Coactivator Amplified in Breast and Ovarian Cancer

1997 • 1,655 citations

Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation

1996 • 1,567 citations

Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300

1997 • 1,472 citations

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1996 • 1,457 citations

Steroid receptor coactivator-1 is a histone acetyltransferase

1997 • 1,245 citations

Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP

1995 • 1,197 citations

A positive role for histone acetylation in transcription factor access to nucleosomal DNA

1993 • 1,116 citations

Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.

1997 • 1,053 citations

Chromatin Structure and Function

1979 • 1,050 citations

The general transcription factors of RNA polymerase II.

1996 • 1,010 citations

The role of general initiation factors in transcription by RNA polymerase II

1996 • 1,001 citations

A direct link between core histone acetylation and transcriptionally active chromatin.

1988 • 905 citations

Chromatin as an essential part of the transcriptional mechanim

1992 • 853 citations

What's Up and Down with Histone Deacetylation and Transcription?

1997 • 831 citations

Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast

1995 • 778 citations

BIOCHEMISTRY AND STRUCTURAL BIOLOGY OF TRANSCRIPTION FACTOR IID (TFIID)

1996 • 721 citations

The nucleosomal core histone octamer at 3.1 A resolution: a tripartite protein assembly and a left-handed superhelix.

1991 • 720 citations

Four Genes Responsible for a Position Effect on Expression From HML and HMR in Saccharomyces cerevisiae

1987 • 709 citations

The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity

1996 • 705 citations

The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression

1993 • 692 citations

Nucleosome Assembly by a Complex of CAF-1 and Acetylated Histones H3/H4

1996 • 624 citations

Facilitated binding of TATA-binding protein to nucleosomal DNA

1994 • 593 citations

Acetylation of general transcription factors by histone acetyltransferases

1997 • 588 citations

Histone H4 isoforms acetylated at specific lysine residues define individual chromosomes and chromatin domains in Drosophila polytene nuclei

1992 • 552 citations

Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain.

1994 • 539 citations

Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation

1996 • 525 citations

Conservation of deposition-related acetylation sites in newly synthesized histones H3 and H4.

1995 • 500 citations

The p300/CBP family: integrating signals with transcription factors and chromatin

1997 • 482 citations

Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines

1997 • 480 citations

Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro.

1996 • 469 citations

Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4.

1996 • 460 citations

Nucleosome loss activates yeast downstream promoters in vivo

1988 • 456 citations

Repression and activation by multiprotein complexes that alter chromatin structure.

1996 • 444 citations

Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast

1988 • 441 citations

GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein

1997 • 437 citations

The Major Cytoplasmic Histone Acetyltransferase in Yeast: Links to Chromatin Replication and Histone Metabolism

1996 • 429 citations

Histone acetylation reduces nucleosome core particle linking number change

1989 • 394 citations

Binding of transcription factor TFIID to the major late promoter during in vitro nucleosome assembly potentiates subsequent initiation by RNA polymerase II

1987 • 394 citations

The bromodomain: a conserved sequence found in human,Drosophilaand yeast proteins

1992 • 375 citations

Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci in Saccharomyces cerevisiae.

1990 • 350 citations

Identification of a Gene Encoding a Yeast Histone H4 Acetyltransferase

1995 • 341 citations

Topography of the histone octamer surface: repeating structural motifs utilized in the docking of nucleosomal DNA.

1993 • 333 citations

Yeast histone H4 N-terminal sequence is required for promoter activation in vivo

1991 • 330 citations

Modulation of Chromatin Folding by Histone Acetylation

1995 • 311 citations

Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription.

1992 • 302 citations

Linker histories are not essential and affect chromatin condensation in vivo

1995 • 300 citations

Role of chromatin structure in the regulation of transcription by RNA polymerase II

1993 • 298 citations

Abnormal skeletal patterning in embryos lacking a single Cbp allele: A partial similarity with Rubinstein–Taybi syndrome

1997 • 289 citations

TBP-associated factors are not generally required for transcriptional activation in yeast

1996 • 289 citations

Essential Functional Interactions of SAGA, a Saccharomyces cerevisiae Complex of Spt, Ada, and Gcn5 Proteins, With the Snf/Swi and Srb/Mediator Complexes

1997 • 277 citations

Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors.

1994 • 276 citations

Changes in histone gene dosage alter transcription in yeast.

1988 • 275 citations

An activity gel assay detects a single, catalytically active histone acetyltransferase subunit in Tetrahymena macronuclei.

1995 • 275 citations

Participation of core histone "tails" in the stabilization of the chromatin solenoid.

1982 • 264 citations

TBP-TAF complexes: selectivity factors for eukaryotic transcription

1994 • 250 citations

On the biological role of histone acetylation

1990 • 246 citations

Transcription activation in cells lacking TAFIIs

1996 • 238 citations

A histone octamer can step around a transcribing polymerase without leaving the template

1994 • 238 citations

Role of the histone “tails” in the folding of oligonucleosomes depleted of histone H1.

1992 • 238 citations

Histone acetylation: influence on transcription, nucleosome mobility and positioning, and linker histone-dependent transcriptional repression

1997 • 236 citations

An Asymmetric Model for the Nucleosome: A Binding Site for Linker Histones Inside the DNA Gyres

1996 • 233 citations

Histone H3 amino terminus is required for telomeric and silent mating locus repression in yeast

1994 • 227 citations

The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast

1996 • 223 citations

Histone acetyltransferase activity and interaction with ADA2 are critical for GCN5 function invivo

1997 • 208 citations

What determines the folding of the chromatin fiber?

1996 • 204 citations

Role for ADA/GCN5 Products in Antagonizing Chromatin-Mediated Transcriptional Repression

1997 • 203 citations

Histone H3 N-terminal mutations allow hyperactivation of the yeast GAL1 gene in vivo.

1992 • 186 citations

Characterization of Physical Interactions of the Putative Transcriptional Adaptor, ADA2, with Acidic Activation Domains and TATA-binding Protein

1995 • 184 citations

Nucleosome positioning and modification: chromatin structures that potentiate transcription

1994 • 182 citations

Identification of Human Proteins Functionally Conserved with the Yeast Putative Adaptors ADA2 and GCN5

1996 • 182 citations

Yeast TAFII145 Functions as a Core Promoter Selectivity Factor, Not a General Coactivator

1997 • 179 citations

DNA and protein determinants of nucleosome positioning on sea urchin 5S rRNA gene sequences in vitro.

1990 • 176 citations

ADA3, a Putative Transcriptional Adaptor, Consists of Two Separable Domains and Interacts with ADA2 and GCN5 in a Trimeric Complex

1995 • 175 citations

Histone acetylation: facts and questions

1994 • 170 citations

Histone H4 and the maintenance of genome integrity.

1995 • 168 citations

Overcoming a nucleosomal barrier to transcription

1995 • 168 citations

Histone Acetyltransferase Activity Is Conserved between Yeast and Human GCN5 and Is Required for Complementation of Growth and Transcriptional Activation

1997 • 168 citations

Stable nucleosome positioning and complete repression by the yeast alpha 2 repressor are disrupted by amino-terminal mutations in histone H4.

1992 • 160 citations

Chromatin Structure and RNA Polymerase II Connection: Implications for Transcription

1996 • 159 citations

Histones in Transit: Cytosolic Histone Complexes and Diacetylation of H4 During Nucleosome Assembly in Human Cells

1997 • 158 citations

Patterns of histone acetylation

1990 • 151 citations

Histone acetylation in chromatin and chromosomes

1995 • 149 citations

Preferential and asymmetric interaction of linker histones with 5S DNA in the nucleosome.

1993 • 149 citations

Transcriptional coactivators in yeast and beyond

1995 • 146 citations

Yeast TAFII145 Required for Transcription of G1/S Cyclin Genes and Regulated by the Cellular Growth State

1997 • 143 citations

What do linker histones do in chromatin?

1997 • 139 citations

Experimental analysis of chromatin function in transcription control.

1994 • 138 citations

Role of the Histone Amino Termini in Facilitated Binding of a Transcription Factor, GAL4-AH, to Nucleosome Cores

1994 • 136 citations

Role of histone tails in nucleosome remodeling by Drosophila NURF

1997 • 133 citations

Nucleosome Structural Changes Due to Acetylation

1994 • 133 citations

Identification of a non-basic domain in the histone H4 N-terminus required for repression of the yeast silent mating loci.

1992 • 120 citations

Structural and Functional Analysis of Yeast Putative Adaptors

1996 • 119 citations

Histone acetylation alters the capacity of the H1 histones to condense transcriptionally active/competent chromatin.

1990 • 116 citations

SPT20/ADA5 Encodes a Novel Protein Functionally Related to the TATA-Binding Protein and Important for Transcription in Saccharomyces cerevisiae

1996 • 114 citations

Yeast ADA2 protein binds to the VP16 protein activation domain and activates transcription.

1994 • 109 citations

ADA1, a Novel Component of the ADA/GCN5 Complex, Has Broader Effects than GCN5, ADA2, or ADA3

1997 • 104 citations

The Linker Histones and Chromatin Structure: New Twists

1996 • 98 citations

ADA5/SPT20 Links the ADA and SPT Genes, Which Are Involved in Yeast Transcription

1996 • 96 citations

Nucleosomal Particles Open as the Histone Core Becomes Hyperacetylated

1983 • 93 citations

Differential repression of transcription factor binding by histone H1 is regulated by the core histone amino termini.

1994 • 92 citations

Recombinant yeast TFIID, a general transcription factor, mediates activation by the gene-specific factor USF in a chromatin assembly assay.

1990 • 90 citations

Chromatin and transcription

1996 • 89 citations

The amino-terminal tails of the core histones and the translational position of the TATA box determine TBP/TFIIA association with nucleosomal DNA

1995 • 84 citations

Site-Directed Cleavage of DNA by a Linker Histone−Fe(II) EDTA Conjugate: Localization of a Globular Domain Binding Site within a Nucleosome

1996 • 77 citations

Hyperacetylation of core histones does not cause unfolding of nucleosomes. Neutron scatter data accords with disc shape of the nucleosome.

1986 • 75 citations

Yeast histone H4 and H3 N-termini have different effects on the chromatin structure of the GAL1 promoter.

1995 • 74 citations

Genetic evidence for the interaction of the yeast transcriptional co-activator proteins GCN5 and ADA2

1995 • 70 citations

Histone acetylation and gene induction in human cells

1993 • 54 citations

Nucleosome assembly: the CAF and the HAT

1996 • 53 citations

Histones and the Regulation of Heterochromatin in Yeast

1993 • 53 citations

H1-mediated Repression of Transcription Factor Binding to a Stably Positioned Nucleosome

1997 • 51 citations

Modeling eukaryotic transcriptional activation

1994 • 47 citations

A SAGA of histone acetylation and gene expression

1997 • 33 citations

Estradiol enhanced acetylation of nuclear high mobility group proteins of the uterus of newborn guinea pigs

1989 • 21 citations