Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo

Fitting a mixture model by expectation maximization to discover motifs in biopolymers.

1994 • 4,818 citations

Sequence logos: a new way to display consensus sequences

1990 • 3,249 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS

1964 • 2,410 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation

1996 • 1,567 citations

Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300

1997 • 1,472 citations

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1996 • 1,457 citations

Steroid receptor coactivator-1 is a histone acetyltransferase

1997 • 1,245 citations

Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.

1997 • 1,053 citations

The folding of an enzyme

1992 • 931 citations

What's Up and Down with Histone Deacetylation and Transcription?

1997 • 831 citations

Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.

1993 • 795 citations

The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity

1996 • 705 citations

The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression

1993 • 692 citations

SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast.

1997 • 673 citations

Acetylation of general transcription factors by histone acetyltransferases

1997 • 588 citations

Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain.

1994 • 539 citations

Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation

1996 • 525 citations

Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines

1997 • 480 citations

Automated assembly of protein blocks for database searching

1991 • 465 citations

Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4.

1996 • 460 citations

Repression and activation by multiprotein complexes that alter chromatin structure.

1996 • 444 citations

GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein

1997 • 437 citations

Gibbs motif sampling: Detection of bacterial outer membrane protein repeats

1995 • 400 citations

The folding of an enzyme

1992 • 376 citations

Targeting Chromatin Disruption: Transcription Regulators that Acetylate Histones

1996 • 369 citations

Efficient Transcriptional Silencing in Saccharomyces cerevisiae Requires a Heterochromatin Histone Acetylation Pattern

1996 • 363 citations

Reversible histone modification and the chromosome cell cycle

1992 • 357 citations

Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast.

1989 • 325 citations

Pineal Serotonin N -Acetyltransferase: Expression Cloning and Molecular Analysis

1995 • 317 citations

Acetylated histone H4 on the male X chromosome is associated with dosage compensation in Drosophila.

1994 • 308 citations

Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription.

1992 • 302 citations

SWI2/SNF2 and Related Proteins: ATP-Driven Motors That Disrupt-Protein–DNA Interactions?

1997 • 301 citations

Essential Functional Interactions of SAGA, a Saccharomyces cerevisiae Complex of Spt, Ada, and Gcn5 Proteins, With the Snf/Swi and Srb/Mediator Complexes

1997 • 277 citations

Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors.

1994 • 276 citations

Transcription and regulatory signals at the mating type locus in yeast

1984 • 256 citations

Chromatin Unfolds

1996 • 253 citations

Histone H4 acetylation distinguishes coding regions of the human genome from heterochromatin in a differentiation-dependent but transcription-independent manner.

1995 • 249 citations

Maximum Discrimination Hidden Markov Models of Sequence Consensus

1995 • 248 citations

Histone acetylation: influence on transcription, nucleosome mobility and positioning, and linker histone-dependent transcriptional repression

1997 • 236 citations

Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo

1998 • 230 citations

Chromatin remodeling and transcription

1997 • 227 citations

Searching databases of conserved sequence regions by aligning protein multiple-alignments [published erratum appears in Nucleic Acids Res 1996 Nov 1;24(21):4372]

1996 • 223 citations

Triple post‐transcriptional control

1990 • 217 citations

Histone acetyltransferase activity and interaction with ADA2 are critical for GCN5 function invivo

1997 • 208 citations

Role for ADA/GCN5 Products in Antagonizing Chromatin-Mediated Transcriptional Repression

1997 • 203 citations

Characterization of Physical Interactions of the Putative Transcriptional Adaptor, ADA2, with Acidic Activation Domains and TATA-binding Protein

1995 • 184 citations

Histone Acetyltransferase Activity Is Conserved between Yeast and Human GCN5 and Is Required for Complementation of Growth and Transcriptional Activation

1997 • 168 citations

A 3D-1D substitution matrix for protein fold recognition that includes predicted secondary structure of the sequence

1997 • 163 citations

Histone acetylation in chromatin and chromosomes

1995 • 149 citations

Chromatin: Histone acetyltransferases in control

1997 • 139 citations

Experimental analysis of chromatin function in transcription control.

1994 • 138 citations

Structural and Functional Analysis of Yeast Putative Adaptors

1996 • 119 citations

TOPITS: threading one-dimensional predictions into three-dimensional structures.

1995 • 119 citations

Active barnase variants with completely random hydrophobic cores.

1996 • 114 citations

SPT20/ADA5 Encodes a Novel Protein Functionally Related to the TATA-Binding Protein and Important for Transcription in Saccharomyces cerevisiae

1996 • 114 citations

Identification of Native Complexes Containing the Yeast Coactivator/Repressor Proteins NGG1/ADA3 and ADA2

1997 • 113 citations

MAK3 encodes an N-acetyltransferase whose modification of the L-A gag NH2 terminus is necessary for virus particle assembly.

1992 • 111 citations

Histone acetylation and globin gene switching

1992 • 111 citations

Remodeling chromatin structures for transcription: What happens to the histones?

1996 • 110 citations

Yeast ADA2 protein binds to the VP16 protein activation domain and activates transcription.

1994 • 109 citations

Detecting Patterns in Protein Sequences

1994 • 107 citations

ADA1, a Novel Component of the ADA/GCN5 Complex, Has Broader Effects than GCN5, ADA2, or ADA3

1997 • 104 citations

ADA5/SPT20 Links the ADA and SPT Genes, Which Are Involved in Yeast Transcription

1996 • 96 citations

ADR1 Activation Domains Contact the Histone Acetyltransferase GCN5 and the Core Transcriptional Factor TFIIB

1996 • 87 citations

RGFGIGS Is an Amino Acid Sequence Required for Acetyl Coenzyme A Binding and Activity of Human Spermidine/Spermine N1Acetyltransferase

1996 • 82 citations

Genetic evidence for the interaction of the yeast transcriptional co-activator proteins GCN5 and ADA2

1995 • 70 citations

Transcriptional Activation by Yeast PDR1p Is Inhibited by Its Association with NGG1p/ADA3p

1996 • 65 citations

Gene induction in response to unfolded protein in the endoplasmic reticulum is mediated through Ire1p kinase interaction with a transcriptional coactivator complex containing Ada5p

1997 • 63 citations

Structure and critical residues at the active site of spermidine/spermine-N1-acetyltransferase

1996 • 54 citations

Improved shuttle vectors for cloning and high-level Cu2+ -mediated expression of foreign genes in yeast

1991 • 48 citations

The transcription of chromatin templates

1994 • 47 citations

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1996 • 37 citations

Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines

1996 • 35 citations

Structure/Function Properties of the Yeast Dual Regulator Protein NGG1 That Are Required for Glucose Repression

1996 • 34 citations

A SAGA of histone acetylation and gene expression

1997 • 33 citations

Characterization of edg-2, a human homologue of theXenopus maternal transcript G10 from endothelial cells

1995 • 24 citations

PAT1, an evolutionarily conserved acetyltransferase homologue, is required for multiple steps in the cell cycle

1996 • 23 citations

Acetylated histone H4 on the male X chromosome is associated with dosage compensation in Drosophila

1994 • 9 citations