Transcriptional activation by recruitment

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Mechanism of transcriptional activation by Sp1: Evidence for coactivators

1990 • 1,029 citations

MECHANISM AND CONTROL OF TRANSCRIPTION INITIATION IN PROKARYOTES

1985 • 1,012 citations

Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of Yeast

1986 • 946 citations

Deletion analysis of GAL4 defines two transcriptional activating segments

1987 • 898 citations

A Third Recognition Element in Bacterial Promoters: DNA Binding by the α Subunit of RNA Polymerase

1993 • 790 citations

BIOCHEMISTRY AND STRUCTURAL BIOLOGY OF TRANSCRIPTION FACTOR IID (TFIID)

1996 • 721 citations

RSC, an Essential, Abundant Chromatin-Remodeling Complex

1996 • 680 citations

Negative effect of the transcriptional activator GAL4

1988 • 672 citations

Mechanism of Protein Access to Specific DNA Sequences in Chromatin: A Dynamic Equilibrium Model for Gene Regulation

1995 • 651 citations

Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID

1990 • 620 citations

An RNA polymerase II holoenzyme responsive to activators

1994 • 586 citations

Crystal structure of a TFIIB–TBP–TATA-element ternary complex

1995 • 542 citations

Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation

1996 • 525 citations

Expression of sigma 54 (ntrA)-dependent genes is probably united by a common mechanism

1989 • 504 citations

Removal of positioned nucleosomes from the yeast PHO5 promoter upon PHO5 induction releases additional upstream activating DNA elements.

1986 • 470 citations

Nucleosome loss activates yeast downstream promoters in vivo

1988 • 456 citations

Function of a Bacterial Activator Protein That Binds to Transcriptional Enhancers

1989 • 440 citations

Promoter structure, promoter recognition, and transcription activation in prokaryotes

1994 • 439 citations

COMMON THEMES IN ASSEMBLY AND FUNCTION OF EUKARYOTIC TRANSCRIPTION COMPLEXES

1995 • 434 citations

The SWI-SNF complex: a chromatin remodeling machine?

1995 • 379 citations

Structure and function of transcriptional activation domains

1995 • 376 citations

Holo-TFIID supports transcriptional stimulation by diverse activators and from a TATA-less promoter.

1992 • 372 citations

Protein-protein communication within the transcription apparatus

1993 • 366 citations

RNA Polymerase II Holoenzyme Contains SWI/SNF Regulators Involved in Chromatin Remodeling

1996 • 364 citations

Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53.

1994 • 355 citations

Transcription activation at Class I CAP‐dependent promoters

1993 • 350 citations

The carboxy-terminal 30 amino acids of GAL4 are recognized by GAL80

1987 • 349 citations

Bipartite functional map of the E. coli RNA polymerase α subunit: Involvement of the C-terminal region in transcription activation by cAMP-CRP

1991 • 346 citations

Chromatin structure and gene expression.

1996 • 339 citations

Structural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 protein

1988 • 325 citations

Repressor structure and the mechanism of positive control

1983 • 324 citations

The RNA polymerase II holoenzyme and its implications for gene regulation

1995 • 297 citations

KMnO4 as a probe for lac promoter DNA melting and mechanism in vivo

1989 • 294 citations

Binding of TAFs to core elements directs promoter selectivity by RNA polymerase II

1995 • 290 citations

TBP-associated factors are not generally required for transcriptional activation in yeast

1996 • 289 citations

Activation of prokaryotic transcription through arbitrary protein–protein contacts

1997 • 284 citations

Transcription Activation at Class II CAP-Dependent Promoters: Two Interactions between CAP and RNA Polymerase

1996 • 277 citations

Three Functional Classes of Transcriptional Activation Domains

1996 • 267 citations

Contact with a component of the polymerase II holoenzyme suffices for gene activation

1995 • 262 citations

Initiation of transcription at the bacterial glnAp2 promoter by purified E. coli components is facilitated by enhancers

1987 • 254 citations

A Model for the Cooperative Binding of Eukaryotic Regulatory Proteins to Nucleosomal Target Sites

1996 • 251 citations

Functional interdependence of the yeast SNF2, SNF5, and SNF6 proteins in transcriptional activation.

1991 • 244 citations

Transcription activation in cells lacking TAFIIs

1996 • 238 citations

Association of an activator with an RNA polymerase II holoenzyme.

1995 • 237 citations

Domain organization of RNA polymerase α subunit: C-terminal 85 amino acids constitute a domain capable of dimerization and DNA binding

1994 • 237 citations

Probing the Escherichia coli glnALG upstream activation mechanism in vivo.

1988 • 233 citations

Mechanism of CRP-cAMP activation of lac operon transcription initiation activation of the P1 promoter

1984 • 228 citations

Molecular mechanisms of transcriptional regulation in yeast

1990 • 224 citations

The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast

1996 • 223 citations

Transcriptional antitermination

1993 • 216 citations

Mechanism of activation of transcription initiation from the λPRM promoter

1982 • 210 citations

Quantitation of putative activator-target affinities predicts transcriptional activating potentials.

1996 • 195 citations

Connecting a promoter-bound protein to TBP bypasses the need for a transcriptional activation domain

1995 • 188 citations

Target of the Transcriptional Activation Function of Phage λ cl Protein

1994 • 182 citations

Peptide–Surface Association: The Case of PDZ and PTB Domains

1996 • 178 citations

Mutations that alter the ability of theEscherichia colicyclic AMP receptor protein to activate transcription

1990 • 174 citations

A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID

1992 • 170 citations

Identification of the Target of a Transcription Activator Protein by Protein-Protein Photocrosslinking

1994 • 166 citations

Yeast TAF IIS in a multisubunit complex required for activated transcription

1994 • 163 citations

Transcription activation at Class II CAP‐dependent promoters

1997 • 161 citations

Stimulation of RNA polymerase II transcription initiation by recruitment of TBP in vivo

1995 • 161 citations

Chromatin Structure and RNA Polymerase II Connection: Implications for Transcription

1996 • 159 citations

The bacterial enhancer-binding protein NTRC is a molecular machine: ATP hydrolysis is coupled to transcriptional activation.

1995 • 159 citations

CCAAT/enhancer binding protein-alpha amino acid motifs with dual TBP and TFIIB binding ability co-operate to activate transcription in both yeast and mammalian cells.

1995 • 157 citations

The prokaryotic enhancer binding protein NTRC has an ATPase activity which is phosphorylation and DNA dependent.

1992 • 157 citations

Expression of sigma 54 (ntrA)-dependent genes is probably united by a common mechanism.

1989 • 149 citations

Identification of the activating region of catabolite gene activator protein (CAP): isolation and characterization of mutants of CAP specifically defective in transcription activation.

1993 • 146 citations

Yeast TAF(II)90 is required for cell-cycle progression through G2/M but not for general transcription activation.

1996 • 141 citations

Genetic evidence that an activation domain of GAL4 does not require acidity and may form a β sheet

1993 • 138 citations

RNA Polymerase II Holoenzyme Recruitment Is Sufficient to Remodel Chromatin at the Yeast PHO5 Promoter

1997 • 133 citations

Gene activation by recruitment of the RNA polymerase II holoenzyme.

1996 • 123 citations

The regulation of nitrogen utilization in enteric bacteria

1993 • 117 citations

Location, structure, and function of the target of a transcriptional activator protein.

1994 • 113 citations

Dynamic Protein-DNA Architecture of a Yeast Heat Shock Promoter

1995 • 111 citations

Regulation of transcriptional elongation by RNA polymerase II

1995 • 111 citations

Synergy between Escherichia coli CAP protein and RNA polymerase in the lac promoter open complex

1989 • 110 citations

Effects of activation-defective TBP mutations on transcription initiation in yeast

1994 • 110 citations

Role of the Sigma70 Subunit of Escherichia coli RNA Polymerase in Transcription Activation

1994 • 110 citations

Gene regulation at the right operator (OR) of bacteriophage λ

1980 • 108 citations

Recruiting TATA-Binding Protein to a Promoter: Transcriptional Activation without an Upstream Activator

1995 • 108 citations

Functional Domains of a Positive Regulatory Protein, PH04, for Transcriptional Control of the Phosphatase Regulon in Saccharomyces cerevisiae

1990 • 106 citations

Repression and activation of transcription by Gal and Lac repressors: involvement of alpha subunit of RNA polymerase.

1995 • 104 citations

Amino acid substitutions in the -35 recognition motif of sigma 70 that result in defects in phage lambda repressor-stimulated transcription

1994 • 94 citations

A single glutamic acid residue plays a key role in the transcriptional activation function of lambda repressor

1989 • 94 citations

Mutant lambda phage repressor with a specific defect in its positive control function.

1982 • 93 citations

Synergistic Activation of Transcription by Bacteriophage λ cI Protein and E. coli cAMP Receptor Protein

1994 • 83 citations

Modulation of promoter occupancy by cooperative DNA binding and activation-domain function is a major determinant of transcriptional regulation by activators in vivo.

1996 • 80 citations

Transcriptional co‐activation at the ansB promoters: involvement of the activating regions of CRP and FNR when bound in tandem

1995 • 77 citations

Synergistic and promoter-selective activation of transcription by recruitment of transcription factors TFIID and TFIIB

1997 • 73 citations

Short Transcripts of the Ternary Complex Provide Insight into RNA Polymerase II Elongational Pausing

1995 • 73 citations

RNA Polymerase β′ Subunit: A Target of DNA Binding-Independent Activation

1997 • 71 citations

Mutations in the RNA polymerase recognition sequence of theKlebsiella pneumoniae nifHpromoter permitting transcriptional activation in the absence of NifA binding to upstream activator sequences

1989 • 70 citations

Functional domains of a positive regulatory protein, PHO4, for transcriptional control of the phosphatase regulon in Saccharomyces cerevisiae.

1990 • 67 citations

Transcription Activation by the Escherichia coli Cyclic AMP

1994 • 66 citations

Mutant forms of the enhancer-binding protein NtrC can activate transcription from solution

1997 • 60 citations

Reciprocal interferences between nucleosomal organization and transcriptional activity of the yeast SNR6 gene.

1995 • 59 citations

Changing the mechanism of transcriptional activation by phage λ repressor

1997 • 55 citations

Activation and repression of transcription at two different phage phi29 promoters are mediated by interaction of the same residues of regulatory protein p4 with RNA polymerase.

1996 • 55 citations

Dual regulation of open-complex formation and promoter clearance by Arc explains a novel repressor to activator switch.

1996 • 38 citations

Transcriptional Activation: A holistic view of the complex

1995 • 20 citations

Micrococcal nuclease as a probe for bound and distorted DNA in lac transcription and repression complexes

1989 • 18 citations