The transactivation domain of Pho4 is required for nucleosome disruption at the PHO5 promoter.

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

The "megaprimer" method of site-directed mutagenesis.

1990 • 1,174 citations

Chromatin as an essential part of the transcriptional mechanim

1992 • 853 citations

Yeast shuttle and integrative vectors with multiple cloning sites suitable for construction of lacZ fusions

1986 • 623 citations

Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection

1992 • 567 citations

Removal of positioned nucleosomes from the yeast PHO5 promoter upon PHO5 induction releases additional upstream activating DNA elements.

1986 • 470 citations

Critical Structural Elements of the VP16 Transcriptional Activation Domain

1991 • 461 citations

Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains

1992 • 446 citations

Nucleosome positioning modulates accessibility of regulatory proteins to the mouse mammary tumor virus promoter

1990 • 440 citations

Phosphorylation of the Transcription Factor PHO4 by a Cyclin-CDK Complex, PHO80-PHO85

1994 • 361 citations

Specific glucocorticoid receptor binding to DNA reconstituted in a nucleosome.

1988 • 316 citations

Facilitated binding of GAL4 and heat shock factor to nucleosomal templates: differential function of DNA-binding domains.

1991 • 269 citations

Nuclease hypersensitive regions with adjacent positioned nucleosomes mark the gene boundaries of the PHO5/PHO3 locus in yeast.

1986 • 254 citations

Activation domains of stably bound GAL4 derivatives alleviate repression of promoters by nucleosomes

1991 • 242 citations

Single amino acid substitutions alter helix-loop-helix protein specificity for bases flanking the core CANNTG motif.

1992 • 199 citations

Nucleosome Core Displacement in Vitro via a Metastable Transcription Factor-Nucleosome Complex

1992 • 198 citations

Multiple functions of nucleosomes and regulatory factors in transcription

1993 • 187 citations

Nucleosome displacement in transcription

1993 • 179 citations

The two positively acting regulatory proteins PHO2 and PHO4 physically interact with PHO5 upstream activation regions.

1989 • 160 citations

Nucleosome disruption at the yeast PHO5 promoter upon PHO5 induction occurs in the absence of DNA replication

1992 • 159 citations

A functional role for nucleosomes in the repression of a yeast promoter.

1991 • 156 citations

A histone-binding protein, nucleoplasmin, stimulates transcription factor binding to nucleosomes and factor-induced nucleosome disassembly.

1994 • 150 citations

Role of trans-activating proteins in the generation of active chromatin at the PHO5 promoter in S. cerevisiae.

1990 • 143 citations

Structure(?) and function of acidic transcription activators

1993 • 136 citations

A nucleosome precludes binding of the transcription factor Pho4 in vivo to a critical target site in the PHO5 promoter.

1994 • 134 citations

The structure and assembly of active chromatin

1990 • 133 citations

The C-terminal 79 amino acids of the herpes simplex virus regulatory protein, Vmw65, efficiently activate transcription in yeast and mammalian cells in chimeric DNA-binding proteins.

1989 • 127 citations

Structural and Functional Requirements for the Chromatin Transition at the PHO5 Promoter in Saccharomyces cerevisiae upon PHO5 Activation

1993 • 123 citations

DNA sequence of the herpes simplex virus type 1 gene whose product is responsible for transcriptional activation of immediate early promoters

1985 • 122 citations

Function of the PHO regulatory genes for repressible acid phosphatase synthesis in Saccharomyces cerevisiae

1989 • 113 citations

A deletion that includes the signal peptidase cleavage site impairs processing, glycosylation, and secretion of cell surface yeast acid phosphatase.

1984 • 112 citations

[22] Propagation and expression of cloned genes in yeast: 2-μm circle-based vectors

1990 • 111 citations

GAL4 disrupts a repressing nucleosome during activation of GAL1 transcription in vivo.

1993 • 109 citations

Functional Domains of a Positive Regulatory Protein, PH04, for Transcriptional Control of the Phosphatase Regulon in Saccharomyces cerevisiae

1990 • 106 citations

Nucleosome Disruption by Transcription Factor Binding in Yeast

1993 • 87 citations

Histones, nucleosomes and transcription

1993 • 72 citations

Transactivation functions facilitate the disruption of chromatin structure by estrogen receptor derivatives in vivo.

1991 • 52 citations

Activation of the weakly regulated PHO8 promoter inS.cerevisiae:chromatin transition and binding sites for the positive regulatory protein PHO4

1992 • 50 citations

The activation domain of a basic helix-loop-helix protein is masked by repressor interaction with domains distinct from that required for transcription regulation.

1994 • 49 citations

The acid phosphatase genes PHO10 and PHO11 inS.cerevisiaeare located at the telomeres of chromosomes VIII and I

1989 • 33 citations

A Deletion That Includes the Signal Peptidase Cleavage Site Impairs Processing, Glycosylation, and Secretion of Cell Surface Yeast Acid Phosphatase

1984 • 31 citations

Negative regulators of the PHO system of Saccharomyces cerevisiae: characterization of PHO80 and PHO85

1992 • 22 citations

A novel mutation occurring in the PHO80 gene suppresses the PHO4 c mutations of Saccharomyces cerevisiae

1992 • 16 citations