The role of T-regulatory cells in pregnancy and cancer

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?

1993 • 2,828 citations

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

1998 • 2,538 citations

Ido expression by dendritic cells: tolerance and tryptophan catabolism

2004 • 2,235 citations

Intraepithelial CD8⁺tumor-infiltrating lymphocytes and a high CD8⁺/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

2005 • 2,226 citations

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

2003 • 2,177 citations

Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

2000 • 2,074 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Regulatory T cells mediate maternal tolerance to the fetus

2004 • 1,568 citations

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

1999 • 1,475 citations

Progress in human tumour immunology and immunotherapy

2001 • 1,327 citations

Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.

1999 • 1,066 citations

Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

2002 • 1,035 citations

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

2001 • 1,033 citations

CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent manner

2005 • 889 citations

CD4⁺CD25⁺ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative

2004 • 854 citations

Some immunological and endocrinological problems raised by the evolution of viviparity in verte- brates

1953 • 838 citations

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

2005 • 783 citations

Normal human pregnancy is associated with an elevation in the immune suppressive CD25⁺ CD4⁺ regulatory T‐cell subset

2004 • 727 citations

Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases

2004 • 727 citations

Regulatory T cells in cancer

2006 • 717 citations

Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4+CD25+ regulatory T cell proliferation

2005 • 716 citations

Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysis

1997 • 691 citations

Foxp3 Expressing CD4+CD25high Regulatory T Cells Are Overrepresented in Human Metastatic Melanoma Lymph Nodes and Inhibit the Function of Infiltrating T Cells

2004 • 680 citations

Increased Populations of Regulatory T Cells in Peripheral Blood of Patients with Hepatocellular Carcinoma

2005 • 618 citations

Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy

1996 • 615 citations

Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells.

2006 • 587 citations

Inhibition of Indoleamine 2,3-Dioxygenase in Dendritic Cells by Stereoisomers of 1-Methyl-Tryptophan Correlates with Antitumor Responses

2007 • 571 citations

T Cell Awareness of Paternal Alloantigens During Pregnancy

1995 • 568 citations

Abnormal T-Cell Reactivity against Paternal Antigens in Spontaneous Abortion

2005 • 533 citations

Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma

2003 • 525 citations

Cutting Edge: Estrogen Drives Expansion of the CD4+CD25+ Regulatory T Cell Compartment

2004 • 510 citations

Large-scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells

2004 • 505 citations

Interleukin-10–Treated Human Dendritic Cells Induce a Melanoma-Antigen–Specific Anergy in CD8+ T Cells Resulting in a Failure to Lyse Tumor Cells

1999 • 499 citations

The Expression of the Regulatory T Cell–Specific Forkhead Box Transcription Factor FoxP3 Is Associated with Poor Prognosis in Ovarian Cancer

2005 • 494 citations

Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers.

2003 • 487 citations

MHC class I antigens, immune surveillance, and tumor immune escape

2003 • 475 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells

2012 • 462 citations

Cutting Edge: Induced Indoleamine 2,3 Dioxygenase Expression in Dendritic Cell Subsets Suppresses T Cell Clonal Expansion

2003 • 460 citations

Outcome in Hodgkin's Lymphoma Can Be Predicted from the Presence of Accompanying Cytotoxic and Regulatory T Cells

2005 • 453 citations

The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs

2005 • 439 citations

A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance.

1990 • 409 citations

CD4+CD25+ T Regulatory Cells Suppress NK Cell-Mediated Immunotherapy of Cancer

2006 • 395 citations

A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation

2005 • 390 citations

Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects

2005 • 373 citations

A progesterone-dependent immunomodulatory protein alters the Th1Th2 balance

1996 • 347 citations

Eradication of established intracranial rat gliomas by transforming growth factor beta antisense gene therapy.

1996 • 341 citations

Phenotypic characterization of regulatory T cells in the human decidua

2004 • 338 citations

Evasion from NK Cell Immunity by MHC Class I Chain-Related Molecules Expressing Colon Adenocarcinoma

2003 • 319 citations

Pregnancy-Associated Exosomes and Their Modulation of T Cell Signaling

2006 • 300 citations

Prevalent expression of the immunostimulatory MHC class I chain–related molecule is counteracted by shedding in prostate cancer

2004 • 297 citations

Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens

2002 • 289 citations

Cutting Edge: CpG Oligonucleotides Induce Splenic CD19+ Dendritic Cells to Acquire Potent Indoleamine 2,3-Dioxygenase-Dependent T Cell Regulatory Functions via IFN Type 1 Signaling

2005 • 289 citations

Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific

2004 • 279 citations

Macrophage Infiltration and Heme Oxygenase-1 Expression Correlate with Angiogenesis in Human Gliomas

2001 • 278 citations

Transforming growth factor-beta-induced inhibition of T cell function. Susceptibility difference in T cells of various phenotypes and functions and its relevance to immunosuppression in the tumor-bearing state.

1991 • 266 citations

Tumor-Induced Expansion of Regulatory T Cells by Conversion of CD4+CD25− Lymphocytes Is Thymus and Proliferation Independent

2006 • 252 citations

Inhibition of Heme Oxygenase-1 Increases Responsiveness of Pancreatic Cancer Cells to Anticancer Treatment

2005 • 248 citations

Perspectives of γδ T Cells in Tumor Immunology

2007 • 248 citations

Dendritic Cells in the Human Decidua

2003 • 246 citations

Indoleamine 2,3-dioxygenase is a novel prognostic indicator for endometrial cancer

2006 • 244 citations

CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition

2006 • 236 citations

Shifts in the TH1/TH2 Balance during Human Pregnancy Correlate with Apoptotic Changes

1998 • 236 citations

Differential Distribution of CD4+CD25bright and CD8+CD28− T-cells in Decidua and Maternal Blood During Human Pregnancy

2006 • 235 citations

Antigen-Specific FoxP3-Transduced T-Cells Can Control Established Type 1 Diabetes

2005 • 231 citations

Depletion of CD25(+) CD4(+) T cells and treatment with tyrosinase-related protein 2-transduced dendritic cells enhance the interferon alpha-induced, CD8(+) T-cell-dependent immune defense of B16 melanoma.

2001 • 223 citations

CD200 is a new prognostic factor in multiple myeloma

2006 • 220 citations

In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor.

2003 • 217 citations

CD4+CD25+FOXP3+ Regulatory T Cells Suppress Anti-Tumor Immune Responses in Patients with Colorectal Cancer

2006 • 213 citations

Regulatory T cells induce a privileged tolerant microenvironment at the fetal‐maternal interface

2005 • 208 citations

Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer.

2003 • 208 citations

Interleukin‐10 expressed at early tumour sites induces subsequent generation of CD4⁺ T‐regulatory cells and systemic collapse of antitumour immunity

2001 • 206 citations

Oestradiol potentiates the suppressive function of human CD4⁺ CD25⁺ regulatory T cells by promoting their proliferation

2006 • 192 citations

Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment

2004 • 191 citations

Overexpression of the Heme Oxygenase Gene in Renal Cell Carcinoma

1997 • 187 citations

Expression of heme oxygenase-1 (HSP32) in human prostate: normal, hyperplastic, and tumor tissue distribution

1996 • 187 citations

Decreased Serum Tryptophan Concentration Predicts Poor Prognosis in Malignant Melanoma Patients

2006 • 187 citations

CD4+CD25high regulatory T cells in human pregnancy

2005 • 184 citations

In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation

2005 • 182 citations

Indoleamine 2,3-dioxygenase, tumor-induced tolerance and counter-regulation

2006 • 182 citations

Infectious tolerance and the long‐term acceptance of transplanted tissue

2006 • 168 citations

Th1/Th2 cytokines balance—yin and yang of reproductive immunology

2005 • 167 citations

Induction of a CD4+ T Regulatory Type 1 Response by Cyclooxygenase-2-Overexpressing Glioma

2004 • 166 citations

IDO expression on decidual and peripheral blood dendritic cells and monocytes/macrophages after treatment with CTLA-4 or interferon-γ increase in normal pregnancy but decrease in spontaneous abortion

2005 • 166 citations

MHC class I down-regulation: tumour escape from immune surveillance? (Review)

2004 • 166 citations

Progesterone inhibits mature rat dendritic cells in a receptor-mediated fashion

2007 • 165 citations

Antiapoptotic effect of haem oxygenase-1 induced by nitric oxide in experimental solid tumour

2003 • 163 citations

CD4CD25 regulatory/suppressor T cells prevent allogeneic fetus rejection in mice

2005 • 161 citations

Dominant IL‐10 and TGF‐β mRNA Expression in γδT Cells of Human Early Pregnancy Decidua Suggests Immunoregulatory Potential

2002 • 158 citations

Role of the endometrial tripod interleukin-18, -15, and -12 in inadequate uterine receptivity in patients with a history of repeated in vitro fertilization–embryo transfer failure

2005 • 157 citations

Eosinophil Granulocytes Account for Indoleamine 2,3-Dioxygenase-Mediated Immune Escape in Human Non Small Cell Lung Cancer

2005 • 156 citations

Antibodies selected from combinatorial libraries block a tumor antigen that plays a key role in immunomodulation

2006 • 151 citations

Heme oxygenase‐1 inhibits rat and human breast cancer cell proliferation: mutual cross inhibition with indoleamine 2,3‐dioxygenase

2005 • 148 citations

Inhibition of heme oxygenase‐1 by zinc protoporphyrin IX reduces tumor growth of LL/2 lung cancer in C57BL mice

2006 • 137 citations

The Th2 cytokines IL-4 and IL-10 are not crucial for the completion of allogeneic pregnancy in mice

2001 • 134 citations

Indoleamine 2,3-dioxygenase (IDO) expression in invasive extravillous trophoblast supports role of the enzyme for materno-fetal tolerance

2004 • 134 citations

Alloantigen-enhanced accumulation of CCR5⁺‘effector’ regulatory T cells in the gravid uterus

2006 • 132 citations

FOXP3⁺ regulatory T cells: Current controversies and future perspectives

2006 • 130 citations

In situ analysis of FOXP3+ regulatory T cells in human colorectal cancer

2006 • 122 citations

Interleukin-2-Dependent Mechanisms of Tolerance and Immunity In Vivo

2006 • 119 citations

Increased transforming growth factor beta expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells.

1993 • 113 citations

Association of increased levels of heavy-chain ferritin with increased CD4+ CD25+ regulatory T-cell levels in patients with melanoma.

2003 • 112 citations

Blockade of CD86 Signaling Facilitates a Th2 Bias at the Maternal-Fetal Interface and Expands Peripheral CD4+CD25+ Regulatory T Cells to Rescue Abortion-Prone Fetuses1

2004 • 108 citations

Immunological Analogy Between Allograft Rejection, Recurrent Abortion and Pre-Eclampsia – the Same Basic Mechanism?

2006 • 107 citations

Unexplained sporadic and recurrent miscarrage in the new millennium: a critical analysis of immune mechanisms and treatments

2001 • 106 citations

Human Bladder Carcinoma is Dominated by T-Regulatory Cells and Th1 Inhibitory Cytokines

2006 • 105 citations

The Same Immunoregulatory Molecules Contribute to Successful Pregnancy and Transplantation

2002 • 104 citations

Lymphocyte immunotherapy and its probable mechanism in the maintenance of pregnancy in women with recurrent spontaneous abortion

2004 • 102 citations

IFN-γ Controls the Generation/Activation of CD4+CD25+ Regulatory T Cells in Antitumor Immune Response

2005 • 102 citations

Intercellular Adhesion Molecule-1/LFA-1 Cross Talk Is a Proximate Mediator Capable of Disrupting Immune Integration and Tolerance Mechanism at the Feto-Maternal Interface in Murine Pregnancies

2005 • 100 citations

Both Regulatory T Cells and Antitumor Effector T Cells Are Primed in the Same Draining Lymph Nodes during Tumor Progression

2005 • 99 citations

Targeting Tumor-Related Immunosuppression for Cancer Immunotherapy

2006 • 91 citations

Comparison of decidual leukocytes following spontaneous vaginal delivery and elective cesarean section in uncomplicated human term pregnancy

2004 • 91 citations

Heme Oxygenases in Pregnancy II: HO‐2 is Downregulated in Human Pathologic Pregnancies

2003 • 89 citations

The role of regulatory T cells in alloantigen tolerance

2006 • 87 citations

Effect Of Human Natural Killer and γδ T Cells on the Growth of Human Autologous Melanoma Xenografts in SCID Mice

2004 • 86 citations

Deregulated cytokine network and defective Th1 immune response in multiple myeloma

2001 • 85 citations

Co‐expression of Thymidine Phosphorylase and Heme Oxygenase‐1 in Macrophages in Human Malignant Vertical Growth Melanomas

2000 • 85 citations

FOXP3 ensembles in T‐cell regulation

2006 • 77 citations

CD4⁺CD25⁺Regulatory T Lymphocytes in Malignant Pleural Effusion

2005 • 75 citations

The Impact of Dydrogesterone Supplementation on Hormonal Profile and Progesterone‐induced Blocking Factor Concentrations in Women with Threatened Abortion

2005 • 71 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3[+]CD25[+]CD4[+] regulatory T cells

2006 • 70 citations

CD4−8− Dendritic Cells Prime CD4+ T Regulatory 1 Cells to Suppress Antitumor Immunity

2005 • 68 citations

A Th2 Chemokine, TARC, Produced by Trophoblasts and Endometrial Gland Cells, Regulates the Infiltration of CCR4⁺ T Lymphocytes into Human Decidua at Early Pregnancy

2002 • 67 citations

Distinct and Overlapping Roles of Interleukin-10 and CD25+ Regulatory T Cells in the Inhibition of Antitumor CD8 T-Cell Responses

2005 • 66 citations

Protection from Abortion by Heme Oxygenase-1 Up-Regulation Is Associated with Increased Levels of Bag-1 and Neuropilin-1 at the Fetal-Maternal Interface

2005 • 64 citations

Potential of human γδ T lymphocytes for immunotherapy of cancer

2004 • 60 citations

Pregnancy associated hormones modulate the cytokine production but not the phenotype of PBMC-derived human dendritic cells

2005 • 56 citations

Evidence of a role for CD200 in regulation of immune rejection of leukaemic tumour cells in C57BL/6 mice

2001 • 56 citations

Exposure to myeloma cell lysates affects the immune competence of dendritic cells and favors the induction of Tr1‐like regulatory T cells

2005 • 56 citations

Reduced Uterine Indoleamine 2,3‐Dioxygenase Versus Increased Th1/Th2 Cytokine Ratios as a Basis for Occult and Clinical Pregnancy Failure in Mice and Humans

2005 • 54 citations

Indoleamine 2,3‐Dioxygenase Expression in Patients with Acute Graft‐versus‐Host Disease after Allogeneic Stem Cell Transplantation and in Pregnant Women: Association with the Induction of Allogeneic Immune Tolerance?

2003 • 53 citations

Differential in vivo and in vitro HLA-G expression in melanoma cells: potential mechanisms

2003 • 50 citations

Cancer and Pregnancy Share Similar Mechanisms of Immunological Escape

2006 • 50 citations

Blockade of CD80 and CD86 at the time of implantation inhibits maternal rejection to the allogeneic fetus in abortion-prone matings

2005 • 49 citations

Interleukin-10–Treated Human Dendritic Cells Induce a Melanoma-Antigen–Specific Anergy in CD8+ T Cells Resulting in a Failure to Lyse Tumor Cells

1999 • 49 citations

A putative mechanism on remission of multiple sclerosis during pregnancy: estrogen-induced indoleamine 2,3-dioxygenase by dendritic cells

2007 • 47 citations

Generation of antigen-specific, interleukin-10-producing T-cells using dendritic cell stimulation and steroid hormone conditioning

2003 • 45 citations

Kinetics of murine decidual dendritic cells

2007 • 45 citations

Interleukin‐10 mRNA expression in B‐cell chronic lymphocytic leukaemia inversely correlates with progression of disease

1996 • 40 citations

Innate Anti-breast Cancer Immunity of Apoptosis-resistant Human γδ-T cells

2005 • 39 citations

Loss of Surface CD200 on Stored Allogeneic Leukocytes may Impair Anti‐abortive Effect In Vivo

2005 • 36 citations

Interleukin-16 in tuberculous and malignant pleural effusions

2005 • 35 citations

High levels of Fas ligand and MHC class II in the absence of CD80 or CD86 expression and a decreased CD4+ T cell Infiltration, enables murine skin tumours to progress

2003 • 33 citations

Tumor-Infiltrating Dendritic Cell Subsets of Progressive or Regressive Tumors Induce Suppressive or Protective Immune Responses

2005 • 32 citations

Dendritic Cells Therapy Confers a Protective Microenvironment in Murine Pregnancy

2006 • 30 citations

Immunoregulatory T Cells in the Peripheral Blood of Patients with Hodgkin’s Lymphoma

2006 • 29 citations

IL-10 transgenic mice present a defect in T cell development reminiscent of SCID patients.

1999 • 27 citations

Polymorphisms in the Interleukin-10 and Interferon Gamma Genes in Hodgkin Lymphoma

2003 • 24 citations

Adoptive Transfer of Paternal Antigen-Hyporesponsive T Cells Induces Maternal Tolerance to the Allogeneic Fetus in Abortion-Prone Matings

2004 • 23 citations

Are Indoleamine-2,3-Dioxygenase Producing Human Dendritic Cells a Tool for Suppression of Allogeneic T-cell Responses?

2007 • 22 citations

Mature Dendritic Cells Induce Tumor-Specific Type 1 Regulatory T Cells

2005 • 21 citations

IL-10 Transgenic Mice Present a Defect in T Cell Development Reminiscent to SCID Patients

1999 • 20 citations

Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy

1997 • 16 citations

Distinct tumor specific expression of TGFB4 ebaf a novel human gene of the TGF- szlig nbsp superfamily

1997 • 15 citations

Asymmetric antibodies (AAb) in the female reproductive tract

2004 • 12 citations

Interleukin-2-dependent mechanisms of tolerance and immunity in vivo

2006 • 10 citations

Comparison of decidual leukocytes following spontaneous vaginal delivery and elective cesarean section in uncomplicated human term pregnancy*1

2004 • 7 citations

Differential in vivo and in vitro HLA-G expression in melanoma cells: potential mechanisms

2003 • 4 citations

Deleted Work

1955 • 0 citations