Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer.

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Mechanisms of angiogenesis and arteriogenesis

2000 • 4,120 citations

Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications

1988 • 1,699 citations

Cancer statistics, 1994

1994 • 1,345 citations

Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury.

1996 • 1,116 citations

Isolation and Characterization of a cDNA from the Rat Brain that Encodes Hemoprotein Heme Oxygenase‐3

1997 • 834 citations

Transcriptional control of rat heme oxygenase by heat shock.

1987 • 415 citations

Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity.

1995 • 343 citations

Endothelin-1 Induces an Angiogenic Phenotype in Cultured Endothelial Cells and Stimulates Neovascularization In Vivo

2000 • 334 citations

Dorsal skinfold chamber technique for intravital microscopy in nude mice.

1993 • 324 citations

In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse

2000 • 323 citations

Macrophage Infiltration and Heme Oxygenase-1 Expression Correlate with Angiogenesis in Human Gliomas

2001 • 278 citations

Regulation of Endothelial Cell Survival and Apoptosis During Angiogenesis

2002 • 274 citations

Clinical Experience with Angiogenesis Signaling Inhibitors: Focus on Vascular Endothelial Growth Factor (VEGF) Blockers

2002 • 268 citations

Cobalt Induction of Hepatic Heme Oxygenase; with Evidence That Cytochrome P -450 Is Not Essential for This Enzyme Activity

1974 • 261 citations

Gene transfer of human heme oxygenase into coronary endothelial cells potentially promotes angiogenesis

1998 • 213 citations

Functional Analysis of cDNAs for Two Types of Human Heme Oxygenase and Evidence for Their Separate Regulation1

1993 • 196 citations

New paradigms for the treatment of cancer: The role of anti-angiogenesis agents

2000 • 194 citations

Overexpression of the Heme Oxygenase Gene in Renal Cell Carcinoma

1997 • 187 citations

Expression of heme oxygenase-1 (HSP32) in human prostate: normal, hyperplastic, and tumor tissue distribution

1996 • 187 citations

Human heme oxygenase-2: Characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal

1992 • 184 citations

Ki-67 immunostaining in node-negative stage I/II breast carcinoma. Significant correlation with prognosis

1991 • 172 citations

Purification and properties of bovine spleen heme oxygenase. Amino acid composition and sites of action of inhibitors of heme oxidation.

1982 • 160 citations

Human Heme Oxygenase-1 Gene Transfer Lowers Blood Pressure and Promotes Growth in Spontaneously Hypertensive Rats

2001 • 159 citations

Sn-protoporphyrin use in the management of hyperbilirubinemia in term newborns with direct Coombs-positive ABO incompatibility.

1988 • 159 citations

Heme Oxygenase-mediated Resistance to Oxygen Toxicity in Hamster Fibroblasts

1997 • 135 citations

Retrovirus-mediated HO gene transfer into endothelial cells protects against oxidant-induced injury

1999 • 126 citations

Controlling tumor angiogenesis and metastasis of C26 murine colon adenocarcinoma by a new matrix metalloproteinase inhibitor, KB-R7785, in two tumor models.

1999 • 107 citations

Direct Comparison of Sn-Mesoporphyrin, An Inhibitor of Bilirubin Production, and Phototherapy in Controlling Hyperbilirubinemia in Term and Near-Term Newborns

1995 • 100 citations

Adenovirus-mediated transfer of p53 and p16INK4a results in pancreatic cancer regression in vitro and in vivo

2001 • 95 citations

How the extracellular matrix and macrophages contribute to angiogenesis-dependent diseases

1996 • 89 citations

Heme oxygenase is a heat shock protein and PEST protein in rat astroglial cells

1992 • 84 citations

A Single Dose of Sn-Mesoporphyrin Prevents Development of Severe Hyperbilirubinemia in Glucose-6-Phosphate Dehydrogenase-Deficient Newborns

2001 • 81 citations

Angiogenesis

1988 • 66 citations

Protective effect of HO-1 against oxidative stress in human hepatoma cell line (HepG2) is independent of telomerase enzyme activity

2002 • 58 citations

Significance of heme oxygenase in prolactin-mediated cell proliferation and angiogenesis in human endothelial cells

2002 • 55 citations

Regulation of human heme oxygenase in endothelial cells by using sense and antisense retroviral constructs

2001 • 55 citations

Sn-Mesoporphyrin Interdiction of Severe Hyperbilirubinemia in Jehovah’s Witness Newborns as an Alternative to Exchange Transfusion

2001 • 52 citations

A Significant Role for the Heme Oxygenase-1 Gene in Endothelial Cell Cycle Progression

2002 • 49 citations

Differential induction of heme oxygenase in the hepatocarcinoma cell line (Hep3B) by environmental agents

1992 • 46 citations

Molecular cloning, characterization, and expression of the chicken heme oxygenase-1 gene in transfected primary cultures of chick embryo liver cells

1998 • 38 citations

Modulation of Corneal Heme Oxygenase Expression by Oxidative Stress Agents

1995 • 31 citations

Alterations in microsomal drug metabolism and heme oxygenase activity in isolated hepatic parenchymal and sinusoidal cells in Murphy-Sturm lymphosarcoma-bearing rats.

1986 • 27 citations

A High Expression of Heme Oxygenase-1 in the Liver of LEC Rats at the Stage of Hepatoma: The Possible Implication of Induction in Uninvolved Tissue

1998 • 17 citations

Microvascular Changes in the Stroma of Human Colorectal Carcinomas: Ultrastructural Histochemical Study

1989 • 15 citations

Advances in diagnosis and treatment of pancreatic cancer.

1995 • 11 citations

Synergistic effect of heme and IL‐1 on hematopoietic stromal regeneration after radiation

1993 • 9 citations