Heme oxygenase‐1 inhibits rat and human breast cancer cell proliferation: mutual cross inhibition with indoleamine 2,3‐dioxygenase

The Hallmarks of Cancer

2000 • 27,569 citations

Proliferation, cell cycle and apoptosis in cancer

2001 • 3,236 citations

THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases

1997 • 2,481 citations

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

2003 • 2,177 citations

GCN2 Kinase in T Cells Mediates Proliferative Arrest and Anergy Induction in Response to Indoleamine 2,3-Dioxygenase

2005 • 1,156 citations

Heme oxygenase-1: unleashing the protective properties of heme

2003 • 1,137 citations

Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury.

1996 • 1,116 citations

Natural selection of tumor variants in the generation of “tumor escape” phenotypes

2002 • 1,014 citations

Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis

2000 • 970 citations

Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences

2000 • 943 citations

Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes

2004 • 834 citations

Indoleamine 2,3-Dioxygenase Production by Human Dendritic Cells Results in the Inhibition of T Cell Proliferation

2000 • 733 citations

Role of nitric oxide in carcinogenesis and tumour progression

2001 • 552 citations

Heme oxygenase-1 protects against vascular constriction and proliferation

2001 • 515 citations

Hypoxia and oxidative stress in breast cancer Oxidative stress - its effects on the growth, metastatic potential and response to therapy of breast cancer

2001 • 468 citations

Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity.

1988 • 459 citations

Error in the determination of tryptophan by the method of Denkla and Dewey. A revised procedure

1974 • 423 citations

The role of mitogen-activated protein (MAP) kinase in breast cancer

2002 • 393 citations

Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action

2003 • 383 citations

Indoleamine 2,3-dioxygenase. Purification and some properties

1978 • 362 citations

Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation.

1981 • 285 citations

1-methyl-dl-tryptophan, β-(3-benzofuranyl)-dl-alanine (the oxygen analog of tryptophan), and β-[3-benzo(b)thienyl]-dl-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase

1991 • 279 citations

Alterations in the apoptotic machinery and their potential role in anticancer drug resistance

2003 • 268 citations

Functional expression of indoleamine 2,3-dioxygenase by murine CD8α+ dendritic cells

2002 • 251 citations

The antiproliferative activity of resveratrol results in apoptosis in MCF-7 but not in MDA-MB-231 human breast cancer cells: cell-specific alteration of the cell cycle

2002 • 235 citations

In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor.

2003 • 217 citations

Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer.

2003 • 208 citations

Characteristics of interferon induced tryptophan metabolism in human cells in vitro

1989 • 191 citations

Induction of Heme Oxygenase-1 Inhibits NAD(P)H Oxidase Activity by Down-regulating Cytochrome b558 Expression via the Reduction of Heme Availability

2004 • 184 citations

Benzo(a)pyrene quinones increase cell proliferation, generate reactive oxygen species, and transactivate the epidermal growth factor receptor in breast epithelial cells.

2003 • 183 citations

[26] Indoleamine 2,3-dioxygenase

1987 • 176 citations

Antiapoptotic effect of haem oxygenase-1 induced by nitric oxide in experimental solid tumour

2003 • 163 citations

Upregulation of heme oxygenase-1 and p21 confers resistance to apoptosis in human gastric cancer cells

2003 • 162 citations

Purification and properties of bovine spleen heme oxygenase. Amino acid composition and sites of action of inhibitors of heme oxidation.

1982 • 160 citations

Identification of Heme Oxygenase-1 As a Novel BCR/ABL-Dependent Survival Factor in Chronic Myeloid Leukemia

2004 • 148 citations

Adenovirus-Mediated Heme Oxygenase-1 Gene Expression Stimulates Apoptosis in Vascular Smooth Muscle Cells

2002 • 141 citations

Gene Transfer of Heme Oxygenase-1 and Carbon Monoxide Delivery Inhibit Chronic Rejection

2002 • 126 citations

Antioxidants Inhibit Indoleamine 2,3-Dioxygenase in IFN-γ-Activated Human Macrophages: Posttranslational Regulation by Pyrrolidine Dithiocarbamate

2001 • 115 citations

Indoleamine 2,3-dioxygenase. Equilibrium studies of the tryptophan binding to the ferric, ferrous, and CO-bound enzymes.

1980 • 113 citations

Regulation of Cyclooxygenase by the Heme-Heme Oxygenase System in Microvessel Endothelial Cells

2002 • 104 citations

Leydig cell–derived heme oxygenase-1 regulates apoptosis of premeiotic germ cells in response to stress

2002 • 97 citations

3-Hydroxyanthranilic acid, one of metabolites of tryptophan via indoleamine 2,3-dioxygenase pathway, suppresses inducible nitric oxide synthase expression by enhancing heme oxygenase-1 expression

2004 • 90 citations

Imbalance of antioxidant enzymes in tumor cells and inhibition of proliferation and malignant features by scavenging hydrogen peroxide

2004 • 88 citations

Overexpression of heme oxygenase-1 protects smooth muscle cells against oxidative injury and inhibits cell proliferation

2002 • 86 citations

Heme oxygenase‐1 modulates the allo‐immune response by promoting activation‐induced cell death of T cells

2005 • 83 citations

Heme Oxygenase Inhibits Human Airway Smooth Muscle Proliferation via a Bilirubin-dependent Modulation of ERK1/2 Phosphorylation

2003 • 77 citations

Heme oxygenase‐1 protects against apoptosis induced by tumor necrosis factor‐α and cycloheximide in papillary thyroid carcinoma cells

2004 • 74 citations

Carbon Monoxide Promotes Fas/CD95-induced Apoptosis in Jurkat Cells

2004 • 68 citations

Antigen-specific T cell functions are suppressed over the estrogen-dendritic cell-indoleamine 2,3-dioxygenase axis

2004 • 68 citations

Heme oxygenase-1 expression predicts cervical lymph node metastasis of tongue squamous cell carcinomas

2003 • 62 citations

Nitric oxide synthase inhibition by haem oxygenase decreases macrophage nitric-oxide-dependent cytotoxicity: a negative feedback mechanism for the regulation of nitric oxide production

1998 • 57 citations

Mechanisms regulating the expression of indoleamine 2,3-dioxygenase during decidualization of human endometrium

2004 • 52 citations

Antibodies to quinolinic acid reveal localization in select immune cells rather than neurons or astroglia

1993 • 40 citations

Neoplastic transformation of mammary epithelial cells in rats is associated with decreased apoptotic cell death

2000 • 27 citations

Anti-bilirubin monoclonal antibody I. Preparation and properties of monoclonal antibodies to covalently coupled bilirubin-albumin

1988 • 27 citations

Isolation and characterization of a serially cultivated, neoplastic, epithelial cell line from theN-nitrosomethylurea induced rat mammary adenocarcinoma

1982 • 20 citations

Heme oxygenase inhibits nitric oxide synthase by degrading heme: a negative feedback regulation mechanism for nitric oxide production

1998 • 15 citations

Immunobiological Characterization of N-Nitrosomethylurea-Induced Rat Breast Carcinomas: Tumoral IL-10 Expression as a Possible Immune Escape Mechanism

2004 • 9 citations