Decreased Serum Tryptophan Concentration Predicts Poor Prognosis in Malignant Melanoma Patients

Nonparametric Estimation from Incomplete Observations

1992 • 45,923 citations

The Hallmarks of Cancer

2000 • 27,569 citations

Interferon-γ: an overview of signals, mechanisms and functions

2003 • 3,785 citations

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

2003 • 2,177 citations

CTLA-4–Ig regulates tryptophan catabolism in vivo

2002 • 1,150 citations

Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma.

1984 • 1,083 citations

Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism

1991 • 1,018 citations

Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.

1984 • 847 citations

Indoleamine 2,3-Dioxygenase Production by Human Dendritic Cells Results in the Inhibition of T Cell Proliferation

2000 • 733 citations

Monitoring tryptophan metabolism in chronic immune activation

2005 • 523 citations

Tolerance and Cancer: Mechanisms of Tumor Evasion and Strategies for Breaking Tolerance

2004 • 319 citations

The Role of Neopterin as a Monitor of Cellular Immune Activation in Transplantation, Inflammatory, Infectious, and Malignant Diseases

1992 • 318 citations

IDO and tolerance to tumors

2003 • 262 citations

Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer

2002 • 228 citations

Tryptophan Catabolism and Regulation of Adaptive Immunity

2003 • 198 citations

More Rapid Method for Simultaneous Measurement of Tryptophan and Kynurenine by HPLC

2002 • 194 citations

Interferon-γ-Induced Conversion of Tryptophan: Immunologic and Neuropsychiatric Aspects

2003 • 194 citations

Indoleamine 2,3-dioxygenase, tumor-induced tolerance and counter-regulation

2006 • 182 citations

Human macrophages degrade tryptophan upon induction by interferon-gamma

1987 • 182 citations

Implications of Interferon-Induced Tryptophan Catabolism in Cancer, Autoimmune Diseases and Aids

1991 • 177 citations

Overexpression of indoleamine 2,3-dioxygenase in human inflammatory bowel disease

2004 • 149 citations

Monocyte-derived dendritic cells release neopterin

2002 • 130 citations

Quantitative Analysis of Melanoma-Induced Cytokine-Mediated Immunosuppression in Melanoma Sentinel Nodes

2005 • 126 citations

Identifying and Overcoming Immune Resistance Mechanisms in the Melanoma Tumor Microenvironment

2006 • 98 citations

The New Melanoma Staging System

2002 • 89 citations

Clinical significance of neopterin for prognosis and follow-up in ovarian cancer.

1987 • 89 citations

Antitumoral Activity of Interferon-γ Involved in Impaired Immune Function in Cancer Patients

2006 • 88 citations

Tryptophan degradation in patients with gynecological cancer correlates with immune activation

2004 • 80 citations

Correlation between neopterin, interferon‐gamma and haemoglobin in patients with haematological disorders

1990 • 77 citations

Neopterin and prognosis in patients with adenocarcinoma of the colon.

1993 • 63 citations

Differential patterns of serum biomarkers of immune activation in human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis, and adult T-cell leukemia/lymphoma.

1996 • 60 citations

Neopterin as a prognostic parameter in patients with squamous-cell carcinomas of the oral cavity

1998 • 30 citations