The impact of p53 loss on murine plasmacytoma development.

p53 Mutations in Human Cancers

1991 • 8,133 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1985 • 1,782 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

2001 • 1,020 citations

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1999 • 828 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation

1996 • 508 citations

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis

2001 • 359 citations

Somatic hypermutation in normal and transformed human B cells

1998 • 351 citations

Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease

1998 • 347 citations

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

1996 • 280 citations

p53 is frequently mutated in Burkitt's lymphoma cell lines.

1991 • 259 citations

Nonrandom chromosome changes involving the Ig gene-carrying chromosomes 12 and 6 in pristane-induced mouse plasmacytomas

1979 • 209 citations

The role of p53 in tumour suppression: lessons from mouse models

1999 • 202 citations

Genomic instability and apoptosis are frequent in p53 deficient young mice

1997 • 197 citations

Plasmacytomagenesis in mice: model of neoplastic development dependent upon chromosomal translocations

1992 • 187 citations

c-Myc trans-activates the p53 promoter through a required downstream CACGTG motif.

1993 • 186 citations

Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif.

1993 • 162 citations

The Mouse Gene Expression Database (GXD)

2001 • 159 citations

Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein

1997 • 153 citations

c-myc/p53 interaction determines sensitivity of human colon carcinoma cells to 5-fluorouracil in vitro and in vivo.

2001 • 110 citations

Immunofixation. III. Application to the study of monoclonal proteins.

1976 • 109 citations

Chromosomal translocations activating myc sequences and transduction of v-abl are critical events in the rapid induction of plasmacytomas by pristane and abelson virus.

1984 • 106 citations

Quantitative analysis of chromosomal CGH in human breast tumors associates copy number abnormalities with p53 status and patient survival

2001 • 97 citations

Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase

1999 • 96 citations

Synergy between a human c-myc transgene and p53 null genotype in murine thymic lymphomas: contrasting effects of homozygous and heterozygous p53 loss.

1995 • 94 citations

Myc/p53 interactions in transgenic mouse mammary development, tumorigenesis and chromosomal instability

1998 • 90 citations

Immunofixation electrophoretic techniques applied to identification of proteins in serum and cerebrospinal fluid.

1976 • 87 citations

Evidence that c-myc mediated apoptosis does not require wild-type p53 during lymphomagenesis.

1995 • 82 citations

p53 in Tumor Progression: Life, Death, and Everything

1998 • 80 citations

The MMTV/c-myc transgene and p53 null alleles collaborate to induce T-cell lymphomas, but not mammary carcinomas in transgenic mice.

1995 • 80 citations

A recurring pattern of chromosomal aberrations in mammary gland tumors of MMTV-cmyc transgenic mice

1999 • 79 citations

c-Myc overexpression associated DHFR gene amplification in hamster, rat, mouse and human cell lines.

1996 • 79 citations

Chromosome instability contributes to loss of heterozygosity in mice lacking p53

2000 • 70 citations

Activation of the c-myc oncogene by the immunoglobulin heavy-chain gene enhancer after multiple switch region-mediated chromosome rearrangements in a murine plasmacytoma.

1985 • 67 citations

c-Myc antagonizes the effect of p53 on apoptosis and p21WAF1 transactivation in K562 leukemia cells

2000 • 60 citations

Quantitative immunoelectrophoresis of serum proteins

1964 • 57 citations

Chromosome changes caused by alterations of p53 expression

1996 • 57 citations

A New Marker for Chromosome Studies in the Mouse

1967 • 56 citations

Overexpression of c-myc precedes amplification of the gene encoding dihydrofolate reductase

1994 • 49 citations

Cytogenetic studies on IgA/lambda-producing murine plasmacytomas: Regular occurrence of a T(12;15) translocation

1980 • 41 citations

Infrequent p53 mutation in mouse tumors with deregulated myc.

1992 • 40 citations

Mechanisms of p53 alteration in acute leukemias.

1994 • 37 citations

EXPERIMENTAL PLASMACYTOMAGENESIS IN MICE

1997 • 36 citations

High resolution banding analysis of the involvement of strain BALB/c- and AKR-derived chromosomes No. 15 in plasmacytoma-specific translocations.

1984 • 35 citations

Biological Activities of p53 Mutants in Burkitt's Lymphoma Cells

1993 • 35 citations

Deregulated expression of c-Myc in a translocation-negative plasmacytoma on extrachromosomal elements that carry IgH and myc genes

1999 • 21 citations

Nonrandom chromosomal change (trisomy 11) in murine plasmacytomas induced by an ABL-MYC retrovirus.

1995 • 20 citations

Upregulation of endogenousp53 and induction of in vivo apoptosis in B-lineage lymphomas ofEμ-myc transgenic mice by deregulated c-myc transgene

1997 • 14 citations

Loss of p53 tumor suppressor function is required for in vivo progression of Friend erythroleukemia

2001 • 11 citations

The “missing” mouse plasmacytoma (MPC) associated translocation T(15;16) occurs repeatedly in new MPC induction systems

1990 • 10 citations

c‐myc Gene in a murine plasmocytoma without visible chromosomal translocations moves to chromosome 12f1 with pvt‐1 and rearranges with IgH enhancer‐Sμ sequences

1991 • 9 citations

Accumulation of p53 protein correlates with tumour proliferative activity in EBV positive Burkitt's lymphoma

1992 • 9 citations

Retroviral enhancer insertion 5' of c-myc in two translocation-negative mouse plasmacytomas upregulates c-myc expression to different extents.

1993 • 9 citations

Murine plasmacytomas, carrier of the t(12;15) chromosomal translocation, develop from immature/mature B cells not from differentiated plasma cells

1999 • 8 citations