Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease

Somatic generation of antibody diversity

1983 • 3,275 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 2,450 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 1,969 citations

Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining.

1975 • 1,734 citations

Clonal selection and learning in the antibody system

1996 • 1,710 citations

IMGT, the international ImMunoGeneTics database

2000 • 877 citations

Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells.

1996 • 749 citations

Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development.

1994 • 691 citations

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.

1993 • 691 citations

Analysis of somatic mutation in five B cell subsets of human tonsil.

1994 • 667 citations

The repertoire of human germline vH sequences reveals about fifty groups of VH segments with different hypervariable loops

1992 • 616 citations

The Pathogenesis of Burkitt's Lymphoma

1990 • 477 citations

Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region

1994 • 382 citations

Somatic hypermutation in normal and transformed human B cells

1998 • 351 citations

Structure and physical map of 64 variable segments in the 3′ 0.8–megabase region of the human immunoglobulin heavy–chain locus

1993 • 332 citations

Immunoglobulin heavy chain gene replacement: A mechanism of receptor editing

1995 • 313 citations

Within Germinal Centers, Isotype Switching of Immunoglobulin Genes Occurs after the Onset of Somatic Mutation

1996 • 310 citations

V(D)J Recombinase Activity in a Subset of Germinal Center B Lymphocytes

1997 • 284 citations

Hodgkin and Reed–Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells

1997 • 276 citations

Neoteny in Lymphocytes: Rag1 and Rag2 Expression in Germinal Center B Cells

1996 • 272 citations

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.

1993 • 271 citations

Stable Expression and Somatic Hypermutation of Antibody V Regions in B-Cell Developmental Pathways

1989 • 271 citations

Somatic hypermutation

1995 • 248 citations

V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses

1997 • 247 citations

Different regions of the immunoglobulin heavy-chain locus are involved in chromosomal translocations in distinct pathogenetic forms of Burkitt lymphoma.

1988 • 245 citations

Discriminating intrinsic and actigen-selected mutational hotspots in immunoglobulin V genes

1993 • 222 citations

Reexpression of RAG-1 and RAG-2 Genes in Activated Mature Mouse B cells

1996 • 219 citations

Detection of the chromosomal translocation t(11;14) by polymerase chain reaction in mantle cell lymphomas

1994 • 207 citations

The t(8; 14) chromosomal translocation occurring in B-cell malignancies results from mistakes in V–D–J joining

1986 • 184 citations

Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes.

1997 • 180 citations

Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells.

1996 • 175 citations

Molecular single cell analysis demonstrates the derivation of a peripheral blood-derived cell line (L1236) from the Hodgkin/Reed- Sternberg cells of a Hodgkin's lymphoma patient

1996 • 170 citations

Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression

1997 • 145 citations

IMGT, the international ImMunoGeneTics database

1997 • 126 citations

Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity

1995 • 114 citations

Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age.

1994 • 108 citations

Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc.

1989 • 106 citations

Burkitt's lymphomas express VH genes with a moderate number of antigen-selected somatic mutations.

1995 • 103 citations

Burkitt’s Lymphoma Is a Malignancy of Mature B Cells Expressing Somatically Mutated V Region Genes

1995 • 98 citations

Structurally abnormal immunoglobulins in human immunoproliferative disorders

1992 • 81 citations

Burkitt lymphoma cell line carrying a variant translocation creates new DNA at the breakpoint and violates the hierarchy of immunoglobulin gene rearrangement.

1985 • 73 citations

Structurally abnormal immunoglobulins in human immunoproliferative disorders

1992 • 71 citations

Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation

1996 • 63 citations

IMGT, the international ImMunoGeneTics database

1997 • 63 citations

Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangement of the kappa‐deleting element (resulting in deletion of the Ig kappa enhancers) abolishes somatic hypermutation in the human

1996 • 62 citations

A DNA insertion/deletion necessitates an aberrant RNA splice accounting for a mu heavy chain disease protein.

1986 • 56 citations

The t(8;14) chromosome translocation of the Burkitt lymphoma cell line Daudi occurred during immunoglobulin gene rearrangement and involved the heavy chain diversity region.

1987 • 52 citations

BCL8 , a novel gene involved in translocations affecting band 15q11–13 in diffuse large-cell lymphoma

1997 • 48 citations

Generation of a Variant T(2;8) Translocation of Burkitt's Lymphoma by Site-Specific Recombination via the Kappa Light-Chain Joining Signals

1987 • 48 citations

N segment insertion and region-directed somatic hypermutation in a Kappa gene of a t(2;8) chromosomal translocation

1987 • 45 citations

Gamma heavy chain disease in man. Genomic sequence reveals two noncontiguous deletions in a single gene.

1988 • 41 citations

THE ROLE OF THE bcl‐2 GENE IN LYMPHOMA

1990 • 39 citations

Genetic recombination in a chromosomal translocation t(2;8) (p11;q24) of a Burkitt's lymphoma cell line, KOBK101

1991 • 29 citations

Three Breakpoints of Variant t(2;8) Translocations in Burkitt's Lymphoma Cells Fall within a Region 140 Kilobases Distal from c-myc

1989 • 25 citations

Variable‐Region Gene Analysis of B‐Cell Subsets Derived from a 4‐Year‐Old Child

1995 • 21 citations

Genomic alterations in a case of α heavy chain disease leading to the generation of composite exons from the jh region

1989 • 18 citations

Molecular single cell studies of normal and transformed lymphocytes.

1997 • 17 citations

Analysis of immunoglobulin gene rearrangements in single B cells

1995 • 16 citations

Multistep evolution of B-cell-derived tumors in humans and rodents

1993 • 16 citations