Overexpression of c-myc precedes amplification of the gene encoding dihydrofolate reductase

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Control of c-myc Regulation in Normal and Neoplastic Cells

1991 • 632 citations

GENE AMPLIFICATION

1984 • 580 citations

Engineering Herbicide Tolerance in Transgenic Plants

1986 • 523 citations

Recent progress in understanding mechanisms of mammalian DNA amplification

1989 • 469 citations

Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max

1992 • 458 citations

Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase

1978 • 426 citations

Alterations of myc , myb , and ras ^Ha Proto-Oncogenes In Cancers Are Frequent and Show Clinical Correlation

1986 • 379 citations

Gene Amplification and Drug Resistance in Cultured Murine Cells

1978 • 317 citations

A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration.

1991 • 248 citations

Direct role for Myc in transcription initiation mediated by interactions with TFII-I

1993 • 246 citations

Origins of DNA replication in metazoan chromosomes.

1993 • 203 citations

Sister chromatid fusion initiates amplification of the dihydrofolate reductase gene in Chinese hamster cells.

1993 • 194 citations

DNA amplification is rare in normal human cells.

1990 • 192 citations

Carcinogen-mediated amplification of viral DNA sequences in simian virus 40-transformed Chinese hamster embryo cells.

1981 • 190 citations

Gene amplification in a single cell cycle in Chinese hamster ovary cells.

1984 • 190 citations

Normal diploid human and rodent cells lack a detectable frequency of gene amplification.

1990 • 179 citations

Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma.

1986 • 173 citations

Regulation and Mechanisms of Mammalian Gene Amplification

1993 • 163 citations

Replication-coupled chromatin assembly is required for the repression of basal transcription in vivo.

1993 • 163 citations

Amplification enhancers and replication origins in the autosomal chorion gene cluster of Drosophila.

1989 • 161 citations

Expression of mad, mxi1, max and c-myc during induced differentiation of hematopoietic cells: opposite regulation of mad and c-myc.

1994 • 159 citations

An embryonically expressed gene is a target for c-Myc regulation via the c-Myc-binding sequence.

1992 • 147 citations

Early dihydrofolate reductase gene amplification events in CHO cells usually occur on the same chromosome arm as the original locus.

1989 • 132 citations

UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells.

1984 • 130 citations

Sequence-Specific Transcriptional Activation by Myc and Repression by Max

1993 • 124 citations

Elevated c-myc expression facilitates the replication of SV40 DNA in human lymphoma cells

1987 • 108 citations

Combined analysis of DNA ploidy index and N-myc genomic content in neuroblastoma.

1991 • 103 citations

Chromosomal destabilization during gene amplification.

1990 • 94 citations

Gene amplification: an example of accelerated evolution in tumorigenic cells.

1985 • 94 citations

Amplification of cellular oncogenes in cancer cells

1985 • 76 citations

Sequence-specific transcriptional activation by Myc and repression by Max.

1993 • 61 citations

Ionizing radiation damage to DNA: Molecular aspects

1989 • 60 citations

Stimulation of methotrexate resistance and dihydrofolate reductase gene amplification by c-myc.

1991 • 59 citations

Multiple origins of replication in the dihydrofolate reductase amplicons of a methotrexate-resistant chinese hamster cell line.

1990 • 48 citations

C-Myc binds to 5′ flanking sequence motifs of the dihydrofolate reductase gene in cellular extracts: role in proliferation

1994 • 47 citations

Origin of adeno-associated virus DNA replication is a target of carcinogen-inducible DNA amplification

1991 • 33 citations

Replication and transcription in the course of DNA amplification of the C3 and C8 DNA puffs of Rhynchosciara americana

1991 • 27 citations

Abnormal DNA content as a biomarker of large bowel cancer risk and prognosis

1992 • 15 citations

The effect of myc proteins on SV40 replication in human lymphoid cells.

1990 • 12 citations

Analysis of c-Myc domains involved in stimulating SV40 replication

1993 • 10 citations

Review: gene amplification--a cellular response to genotoxic stress.

1989 • 9 citations

SV40 DNA Amplification and Reintegration in Surviving Hamster Cells after⁶⁰Co γ-irradiation

1990 • 7 citations

Mechanisms in B-cell neoplasia 1992

1993 • 1 citations