Vascular Endothelial Cell Growth Factor–Induced Tissue Factor Expression in Endothelial Cells Is Mediated by EGR-1

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1987 • 3,088 citations

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1994 • 1,661 citations

A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization

1988 • 1,278 citations

Blood Vessel Formation: What Is Its Molecular Basis?

1996 • 1,242 citations

A Nerve Growth Factor-Induced Gene Encodes a Possible Transcriptional Regulatory Factor

1987 • 1,217 citations

Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration.

1990 • 857 citations

The Vascular Endothelial Growth Factor Receptor Flt-1 Mediates Biological Activities

1996 • 855 citations

A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

1988 • 733 citations

Role of tissue factor in embryonic blood vessel development

1996 • 693 citations

Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells.

1988 • 580 citations

NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules.

1997 • 576 citations

In situ detection of tissue factor in vascular endothelial cells: Correlation with the malignant phenotype of human breast disease

1996 • 544 citations

Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice.

1994 • 488 citations

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1995 • 480 citations

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1997 • 480 citations

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1997 • 472 citations

Induction of Vascular Endothelial Growth Factor by Tumor Necrosis Factor α in Human Glioma Cells

1996 • 459 citations

cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription.

1991 • 388 citations

Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kappa B binding sites.

1991 • 373 citations

Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1

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Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals.

1990 • 343 citations

Mechanisms of nuclear localization of the progesterone receptor: Evidence for interaction between monomers

1989 • 329 citations

Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo.

1991 • 320 citations

Rapid and reversible translocation of the catalytic subunit of cAMP-dependent protein kinase type II from the Golgi complex to the nucleus.

1985 • 317 citations

A Role for Tissue Factor in Cell Adhesion and Migration Mediated by Interaction with Actin-binding Protein 280

1998 • 313 citations

Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation.

1995 • 303 citations

Regulation of the tissue factor gene

1995 • 275 citations

Transforming growth factor-alpha -induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP-2-dependent DNA binding and transactivation

1997 • 256 citations

Activation of coagulation and angiogenesis in cancer: immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer.

1998 • 249 citations

Requirement for binding of catalytically active factor VIIa in tissue factor-dependent experimental metastasis.

1998 • 243 citations

Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin.

1995 • 231 citations

E2F Activity Is Regulated by Cell Cycle-Dependent Changes in Subcellular Localization

1997 • 228 citations

A chemiluminescent assay for quantitation of β-galactosidase in the femtogram range: Application to quantitation of β-galactosidase in lacZ-transfected cells

1991 • 223 citations

A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediate-early transcription factor Egr-1.

1993 • 223 citations

Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade

1989 • 217 citations

Selective Binding of VEGF121 to One of the Three Vascular Endothelial Growth Factor Receptors of Vascular Endothelial Cells

1996 • 200 citations

Detection and characterization of cellular EGR-1 binding to its recognition site

1993 • 193 citations

Repression of the transforming growth factor-beta 1 gene by the Wilms' tumor suppressor WT1 gene product.

1994 • 193 citations

Tissue factor transcription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia

1998 • 180 citations

Nuclear localization of c-Fos, but not v-Fos proteins, is controlled by extracellular signals

1990 • 178 citations

The role of vascular endothelial growth factor in blood vessel formation

1996 • 163 citations

Inducible Expression of Egr-1–Dependent Genes

1997 • 162 citations

Transcriptional Regulation of the Tissue Factor Gene in Human Epithelial Cells Is Mediated by Sp1 and EGR-1

1996 • 160 citations

Regulation of the Tissue Factor Promoter in Endothelial Cells

1995 • 160 citations

Coagulation Factors VII and X Induce Ca2+ Oscillations in Madin-Darby Canine Kidney Cells Only When Proteolytically Active

1996 • 131 citations

Mithramycin blocks transcriptional initiation of the c-myc P1 and P2 promoters

1991 • 125 citations

An upstream enhancer and a negative element in the 5' flanking region of the human urokinase plasminogen activator gene

1988 • 112 citations

Tissue Factor: molecular recognition and cofactor function

1995 • 99 citations

Vascular origin determines plasminogen activator expression in human endothelial cells

1989 • 98 citations

TIS gene expression in cultured rat astrocytes: Induction by mitogens and stellation agents

1989 • 75 citations

Identification and characterisation of the egr-1 gene product as an inducible, short-lived, nuclear phosphoprotein.

1990 • 72 citations

Repression of the transforming growth factor-beta 1 gene by the Wilms' tumor suppressor WT1 gene product

1994 • 70 citations

Nucleocytoplasmic Transport of the Rev Protein of Human Immunodeficiency Virus Type 1 Is Dependent on the Activation Domain of the Protein

1995 • 63 citations

Polar expression of tissue factor in human umbilical vein endothelial cells.

1994 • 44 citations

Human fibroblasts downregulate plasminogen activator inhibitor type-1 in cultured human macrovascular and microvascular endothelial cells

1996 • 39 citations

Modulation of transcription of the platelet-derived growth factor A-chain gene by a promoter region sensitive to S1 nuclease.

1992 • 33 citations

The Molecular Biology of Initiation of Coagulation by Tissue Factor

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A new luciferase promoter insertion vector for the analysis of weak transcriptional activities

1993 • 27 citations

Alterations in endothelial cell proteinase and inhibitor polarized secretion following treatment with interleukin-1, phorbol ester, and human melanoma cell conditioned medium

1996 • 14 citations