Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo.

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter

1983 • 1,471 citations

DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract.

1980 • 1,285 citations

Promoter-specific activation of RNA polymerase II transcription by Sp1

1986 • 1,054 citations

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

1978 • 972 citations

Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro

1985 • 805 citations

Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40

1987 • 762 citations

Activation of the AIDS Retrovirus Promoter by the Cellular Transcription Factor, Sp1

1986 • 741 citations

Transcriptional selectivity of viral genes in mammalian cells

1986 • 722 citations

Multiple specific contacts between a mammalian transcription factor and its cognate promoters

1984 • 565 citations

Distinct Regions of Sp1 Modulate DNA Binding and Transcriptional Activation

1988 • 389 citations

Transcription factor Sp1 recognizes a DNA sequence in the mouse dihydrofolate reductase promoter

1986 • 281 citations

Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1.

1988 • 271 citations

The functional human dihydrofolate reductase gene.

1984 • 245 citations

Chromomycin, mithramycin, and olivomycin binding sites on heterogeneous DNA. Footprinting with methidiumpropyl-EDTA.cntdot.iron(II)

1983 • 218 citations

Methotrexate: clinical pharmacology, current status and therapeutic guidelines

1977 • 203 citations

Gene amplification in a single cell cycle in Chinese hamster ovary cells.

1984 • 190 citations

Unstable Methotrexate Resistance in Human Small-Cell Carcinoma Associated with Double Minute Chromosomes

1983 • 178 citations

Transcriptional regulation of mouse dihydrofolate reductase in the cell cycle.

1985 • 165 citations

Multiple transcription start sites, DNase I-hypersensitive sites, and an opposite-strand exon in the 5' region of the CHO dhfr gene.

1986 • 157 citations

Multiple sequence elements are required for maximal in vitro transcription of a human histone H2B gene.

1986 • 157 citations

Binding of the Sp1 Transcription Factor by the Human Harvey ras 1 Proto-Oncogene Promoter

1986 • 150 citations

Resistance to methotrexate due to gene amplification in a patient with acute leukemia.

1984 • 145 citations

Gene amplification in a leukemic patient treated with methotrexate.

1984 • 139 citations

Mithramycin blocks protein binding and function of the SV40 early promoter.

1989 • 137 citations

Mithramycin blocks transcriptional initiation of the c-myc P1 and P2 promoters

1991 • 125 citations

Isolation of the amplified dihydrofolate reductase domain from methotrexate-resistant Chinese hamster ovary cells.

1987 • 97 citations

Preliminary Observations on the Therapy of the Myeloid Blast Phase of Chronic Granulocytic Leukemia with Plicamycin and Hydroxyurea

1986 • 94 citations

Accumulation of DNA strand breaks during thymineless death in thymidylate synthase-negative mutants of mouse FM3A cells.

1983 • 90 citations

Cell cycle regulation of dihydrofolate reductase mRNA metabolism in mouse fibroblasts.

1980 • 89 citations

Accumulation of DNA strand breaks in cells exposed to methotrexate or N10-propargyl-5,8-dideazafolic acid.

1988 • 81 citations

Rapid Communication: Mithramycin Selectively Inhibits Transcription Of G-C Containing DNA

1987 • 79 citations

Methotrexate resistance and gene amplification. Mechanisms and implications

1986 • 79 citations

Dihydrofolate reductase gene amplification and possible rearrangement in estrogen-responsive methotrexate-resistant human breast cancer cells.

1982 • 75 citations

Multiple Sequence Elements Are Required for Maximal in Vitro Transcription of a Human Histone H2B Gene

1986 • 73 citations

In Vitro Transcription and Delimitation of Promoter Elements of the Murine Dihydrofolate Reductase Gene

1986 • 66 citations

Development of methotrexate resistance in a human squamous cell carcinoma of the head and neck in culture.

1984 • 66 citations

The development of resistance to methotrexate in a mouse melanoma cell line

1979 • 63 citations

Amplification and organization of dihydrofolate reductase genes in a human leukemic cell line, K-562, resistant to methotrexate

1983 • 60 citations

Carcinogen-mediated methotrexate resistance and dihydrofolate reductase amplification in Chinese hamster cells.

1986 • 50 citations

Multiple Transcription Start Sites, DNase I-Hypersensitive Sites, and an Opposite-Strand Exon in the 5′ Region of the CHO dhfr Gene

1986 • 43 citations

Nucleotide sequence and nuclease hypersensitivity of the Chinese hamster dihydrofolate reductase gene promoter region

1986 • 42 citations

Aureolic Acid Group of Anti-tumour Antibiotics

1968 • 36 citations

Flow cytometric analysis by bromodeoxyuridine/DNA assay of cell cycle perturbation of methotrexate-treated mouse L1210 leukemia cells.

1988 • 34 citations

Isolation of the Amplified Dihydrofolate Reductase Domain from Methotrexate-Resistant Chinese Hamster Ovary Cells

1987 • 34 citations

Chromatin structure of the human dihydrofolate reductase gene promoter. Multiple protein-binding sites.

1986 • 32 citations

In vivo differentiation of blast-phase chronic granulocytic leukemia. Expression of c-myc and c-abl protooncogenes.

1985 • 26 citations

Effects of estrogen and tamoxifen on the regulation of dihydrofolate reductase gene expression in a human breast cancer cell line.

1985 • 25 citations

In vitro transcription and delimitation of promoter elements of the murine dihydrofolate reductase gene.

1986 • 23 citations

Regulation of dihydrofolate reductase in human breast cancer cells and in mutant hamster cells transfected with a human dihydrofolate reductase minigene.

1986 • 23 citations

Mithramycin Selectively Inhibits the Transcriptional Activity of a Transfected Human C-myc Gene

1990 • 18 citations

Carcinogen-Mediated Methotrexate Resistance and Dihydrofolate Reductase Amplification in Chinese Hamster Cells

1986 • 15 citations

5' Nucleotide sequences influence serum-modulated expression of a human dihydrofolate reductase minigene.

1986 • 15 citations

Species specific differences in the toxicity of mithramycin, chromomycin A₃, and olivomycin towards cultured mammalian cells

1982 • 10 citations

Characterization of dihydrofolate reductase-related DNA and RNA from human KB cell subclones containing different amounts of enzyme.

1985 • 7 citations

Murine erythroleukemia cell variants: isolation of cells that have amplified the dihydrofolate reductase gene and retained the ability to be induced to differentiate

1986 • 7 citations

5′ Nucleotide Sequences Influence Serum-Modulated Expression of a Human Dihydrofolate Reductase Minigene

1986 • 2 citations