Tissue factor transcription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

2017 • 4,665 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

1992 • 2,420 citations

A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study

1991 • 1,994 citations

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

1994 • 1,821 citations

A Population-Based Perspective of the Hospital Incidence and Case-Fatality Rates of Deep Vein Thrombosis and Pulmonary Embolism

1991 • 1,533 citations

A Prospective Study of Venous Thromboembolism After Major Trauma

1997 • 1,129 citations

A Nuclear Factor Induced by Hypoxia via De Novo Protein Synthesis Binds to the Human Erythropoietin Gene Enhancer at a Site Required for Transcriptional Activation

1992 • 811 citations

Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP.

1995 • 709 citations

Sp1-mediated transcriptional activation is repressed by Sp3.

1994 • 692 citations

Early Growth Response Protein 1 (Egr-1): Prototype of a Zinc-finger Family of Transcription Factors

1995 • 593 citations

Hypoxia and Mitochondrial Inhibitors Regulate Expression of Glucose Transporter-1 via Distinct Cis-acting Sequences

1995 • 553 citations

Hypoxic Regulation of Lactate Dehydrogenase A

1995 • 551 citations

Egr-1-Induced Endothelial Gene Expression: A Common Theme in Vascular Injury

1996 • 525 citations

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.

1994 • 517 citations

The Hypoxic Response: Huffing and HIFing

1997 • 482 citations

Luteinizing Hormone Deficiency and Female Infertility in Mice Lacking the Transcription Factor NGFI-A (Egr-1)

1996 • 479 citations

The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage

1993 • 384 citations

Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms

1994 • 366 citations

Induction of Interleukin 6 (IL-6) by Hypoxia in Vascular Cells

1995 • 348 citations

Hypoxic induction of interleukin-8 gene expression in human endothelial cells.

1994 • 346 citations

Hypoxia-mediated induction of endothelial cell interleukin-1 alpha. An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface.

1992 • 341 citations

Interplay of Sp1 and Egr-1 in the Proximal Platelet-derived Growth Factor A-Chain Promoter in Cultured Vascular Endothelial Cells

1995 • 278 citations

The PO2 in venous valve pockets: Its possible bearing on thrombogenesis

1981 • 194 citations

Growth and Differentiation Proceeds Normally in Cells Deficient in the Immediate Early Gene NGFI-A

1995 • 165 citations

Transcriptional Regulation of the Tissue Factor Gene in Human Epithelial Cells Is Mediated by Sp1 and EGR-1

1996 • 160 citations

Monocytes and tissue factor promote thrombosis in a murine model of oxygen deprivation.

1997 • 154 citations

Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin

1996 • 151 citations

A Regulatory Element in the Human Interleukin 2 Gene Promoter Is a Binding Site for the Zinc Finger Proteins Sp1 and EGR-1

1995 • 150 citations

Transcriptional Regulation by Hypoxia-Inducible Factor 1 Molecular Mechanisms of Oxygen Homeostasis

1996 • 139 citations

Transcriptional regulation of the Icam-1 gene in antigen receptor- and phorbol ester-stimulated B lymphocytes: role for transcription factor EGR1.

1996 • 127 citations

Characterization of an Krox-24/Egr-1-responsive element in the human tumor necrosis factor promoter

1994 • 126 citations

Identification of Hypoxically Inducible mRNAs in HeLa Cells Using Differential‐Display PCR

1996 • 113 citations

Unimpaired Macrophage Differentiation and Activation in Mice Lacking the Zinc Finger Transcription Factor NGFI-A (EGR1)

1996 • 97 citations

Nuclear Factor Interleukin 6 Motifs Mediate Tissue-specific Gene Transcription in Hypoxia

1997 • 78 citations

Oxygen regulated gene expression: Erythropoietin as a model system

1997 • 46 citations

A hypothesis concerning the aetiology of venous thrombosis

1977 • 32 citations

The sequestration and margination of platelets and leucocytes in veins during conditions of hypokinetic and anaemic hypoxia: Potential significance in clinical post‐operative venous thrombosis

1978 • 23 citations

Development of an immunoassay for the COOH-terminal region of the gamma chains of human fibrin

1981 • 18 citations