The regulated production of mu m and mu s mRNA is dependent on the relative efficiencies of mu s poly(A) site usage and the c mu 4-to-M1 splice.

RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression

1987 • 2,333 citations

Transcription termination and 3′ processing: the end is in site!

1985 • 1,482 citations

Changes in size and secondary structure of the ribosomal transcription unit during vertebrate evolution

1975 • 1,188 citations

The Genome of Simian Virus 40

1978 • 948 citations

Splicing of Messenger RNA Precursors

1987 • 919 citations

Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways

1980 • 880 citations

A compensatory base change in U1 snRNA suppresses a 5′ splice site mutation

1986 • 755 citations

Specific transcription and RNA splicing defects in five cloned β-thalassaemia genes

1983 • 627 citations

Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements

1985 • 588 citations

Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3′ ends

1980 • 562 citations

Splice site selection, rate of splicing, and alternative splicing on nascent transcripts.

1988 • 539 citations

Human β-globin pre-mRNA synthesized in vitro is accurately spliced in xenopus oocyte nuclei

1983 • 500 citations

Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: Rearrangement of heavy but not light chain genes

1981 • 497 citations

Steps in the processing of Ad2 mRNA: Poly(A)+ Nuclear sequences are conserved and poly(A) addition precedes splicing

1978 • 478 citations

The "Spliceosome": Yeast Pre-Messenger RNA Associates with a 40 S Complex in a Splicing-Dependent Reaction

1985 • 421 citations

A functional mRNA polyadenylation signal is required for transcription termination by RNA polymerase II.

1988 • 370 citations

The synthesis and processing of the messenger RNAs specifying heavy and light chain immunoglobulins in MPC-11 cells

1978 • 324 citations

A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin gene.

1987 • 247 citations

Alpha-thalassaemia caused by a poly(A) site mutation reveals that transcriptional termination is linked to 3′ end processing in the human alpha 2 globin gene.

1986 • 236 citations

Splice commitment dictates neuron-specific alternative RNA processing in calcitonin/CGRP gene expression

1987 • 204 citations

RNP particles at splice junction sequences on Drosophila chorion transcripts

1985 • 191 citations

Transcription of the unrearranged mouse Cκ locus: Sequence of the initiation region and comparison of activity with a rearranged Vκ-Cκ gene

1981 • 190 citations

Characterization of productive and sterile transcripts from the immunoglobulin heavy-chain locus: processing of micron and muS mRNA.

1983 • 165 citations

The molecular biology of immunoglobulin D

1984 • 152 citations

The role of nucleotide sequences in splice site selection in eukaryotic pre-messenger RNA

1986 • 148 citations

Mode of regulation of immunoglobulin μ- and δ-chain expression varies during B-lymphocyte maturation

1984 • 146 citations

Correlation of hnRNP structure and nascent transcript cleavage

1981 • 137 citations

Immunoelectron microscope visualization of nuclear ribonucleoprotein antigens within spread transcription complexes.

1986 • 123 citations

Complete structure and organization of immunoglobulin heavy chain constant region genes in a phylogenetically primitive vertebrate.

1988 • 122 citations

Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells.

1983 • 121 citations

Transcriptional regulation of the mu-delta heavy chain locus in normal murine B lymphocytes.

1984 • 112 citations

Relative position and strengths of poly(A) sites as well as transcription termination are critical to membrane versus secreted mu-chain expression during B-cell development.

1987 • 110 citations

Regulated production of mu m and mu s mRNA requires linkage of the poly(A) addition sites and is dependent on the length of the mu s-mu m intron.

1986 • 109 citations

Mouse IgA heavy chain gene sequence: implications for evolution of immunoglobulin hinge axons.

1981 • 99 citations

Transcriptional and posttranscriptional control of immunoglobulin mRNA production during Blymphocyte development

1986 • 99 citations

Human 2-5A synthetase: characterization of a novel cDNA and corresponding gene structure.

1985 • 98 citations

The coupling between enhancer activity and hypomethylation of kappa immunoglobulin genes is developmentally regulated.

1988 • 96 citations

Role of an RNA cleavage/poly(A) addition site in the production of membrane-bound and secreted IgM mRNA.

1985 • 93 citations

Poly(A) site choice rather than splice site choice governs the regulated production of IgM heavy-chain RNAs.

1988 • 87 citations

Nucleotide sequence of the constant region of a chicken μ heavy chain immonoglobulin mRNA

1983 • 85 citations

The natural 5' splice site of simian virus 40 large T antigen can be improved by increasing the base complementarity to U1 RNA.

1987 • 84 citations

Amino acid sequence of heavy chain from Xenopus laevis IgM deduced from cDNA sequence: implications for evolution of immunoglobulin domains.

1988 • 84 citations

Nuclear RNA is spliced in the absence of poly(A) addition

1981 • 84 citations

An adenovirus mutant defective in splicing RNA from early region 1A

1981 • 78 citations

3′ End structure of the human (2′–5′) oligo A synthetase gene: prediction of two distinct proteins with cell type-specific expression

1985 • 77 citations

Splice site selection dominates over poly(A) site choice in RNA production from complex adenovirus transcription units.

1988 • 64 citations

The sequence of the human immunoglobulin μ-δ intron reveals possible vestigial switch segments

1984 • 60 citations

Tandem kappa immunoglobulin promoters are equally active in the presence of the kappa enhancer: Implications for models of enhancer function

1986 • 47 citations

Production of RNA for secreted immunoglobulin μ chains does not require transcriptional termination 5′ to the μM exons

1983 • 42 citations

Alternative expression of secreted and membrane forms of immunoglobulin mu-chain is regulated by transcriptional termination in stable plasmacytoma transfectants.

1988 • 42 citations

Effects of intron length on differential processing of mouse mu heavy-chain mRNA.

1987 • 40 citations

Protein-binding site at the immunoglobulin mu membrane polyadenylylation signal: possible role in transcription termination.

1987 • 38 citations

Regulation of differential processing of mouse immunoglobulin μ heavy-chain mRNA

1987 • 37 citations

Phylogenetic conservation of immimoglobulin heavy chains: direct comparison of hamster and mouse Cμ genes

1985 • 30 citations

Cell-Type-Specific Synthesis of Murine Immunoglobulin μ RNA from an Adenovirus Vector

1986 • 28 citations

[58] Procedures for in vitro DNA mutagenesis of human leukocyte interferon sequences

1986 • 27 citations

Processing at immunoglobulin polyadenylation sites in lymphoid cell extracts.

1988 • 23 citations

Nuclear Factors in B Lymphoma Enhance Splicing of Mouse Membrane-Bound μ mRNA inXenopusOocytes

1988 • 18 citations

A novel RNA in which the 5' end is generated by cleavage at the poly(A) site of immunoglobulin heavy-chain secreted mRNA.

1986 • 13 citations