Antithrombotics and the Lipoxygenase Pathway

The Pathogenesis of Atherosclerosis — An Update

1986 • 4,951 citations

Integrins: A family of cell surface receptors

1987 • 4,322 citations

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group.

1988 • 2,740 citations

ARACHIDONIC ACID METABOLISM

1986 • 1,802 citations

PLATELET-DERIVED GROWTH FACTOR

1989 • 967 citations

A Randomized Trial of Aspirin and Sulfinpyrazone in Threatened Stroke

1978 • 933 citations

MEDICAL SCIENCE GISSI-2: A factorial randomised trial of alteplase versus streptokinase and heparin versus no heparin among 12 490 patients with acute myocardial infarction

1990 • 911 citations

Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants.

1985 • 555 citations

Prostaglandin Endoperoxides. A New Concept Concerning the Mode of Action and Release of Prostaglandins

1974 • 495 citations

Platelet and Fibrinogen Consumption in Man

1972 • 492 citations

George Lyman Duff Memorial Lecture. Atherosclerosis: a problem of the biology of arterial wall cells and their interactions with blood components.

1981 • 456 citations

A Comparison between Heparin and Low-Dose Aspirin as Adjunctive Therapy with Tissue Plasminogen Activator for Acute Myocardial Infarction

1990 • 430 citations

DIPYRIDAMOLE AND OTHER PHOSPHODIESTERASE INHIBITORS ACT AS ANTITHROMBOTIC AGENTS BY POTENTIATING ENDOGENOUS PROSTACYCLIN

1978 • 392 citations

Coronary thrombolysis with recombinant human tissue-type plasminogen activator: a prospective, randomized, placebo-controlled trial.

1984 • 387 citations

Reduction in the Rate of Early Restenosis after Coronary Angioplasty by a Diet Supplemented with n–3 Fatty Acids

1988 • 385 citations

BATTERED BABIES—HOW MANY DO WE MISS?

1970 • 365 citations

The role of lipids in platelet function: with particular reference to the arachidonic acid pathway.

1978 • 364 citations

Randomized trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2

1988 • 363 citations

Sulfinpyrazone in the Prevention of Sudden Death after Myocardial Infarction

1980 • 335 citations

Thrombin stimulates tissue plasminogen activator release from cultured human endothelial cells.

1984 • 330 citations

Seeding of intravascular stents with genetically engineered endothelial cells.

1989 • 328 citations

Factors responsible for ADP-induced release reaction of human platelets

1975 • 326 citations

Inhibition of vascular smooth muscle cell growth by endothelial cell-derived heparin. Possible role of a platelet endoglycosidase.

1982 • 312 citations

Aspirin and other antiplatelet agents in the secondary and primary prevention of cardiovascular disease.

1989 • 251 citations

Abolition of in vivo platelet thrombus formation in primates with monoclonal antibodies to the platelet GPIIb/IIIa receptor. Correlation with bleeding time, platelet aggregation, and blockade of GPIIb/IIIa receptors.

1989 • 246 citations

LINOLEIC AND EICOSAPENTAENOIC ACIDS IN ADIPOSE TISSUE AND PLATELETS AND RISK OF CORONARY HEART DISEASE

1987 • 235 citations

Aspirin-like drugs interfere with arachidonate metabolism by inhibition of the 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid peroxidase activity of the lipoxygenase pathway.

1979 • 206 citations

Developing relationships: arterial platelet adhesion, glycoprotein Ib, and leucine-rich glycoproteins

1991 • 205 citations

13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX.

1985 • 196 citations

Modulation of vitronectin receptor binding by membrane lipid composition.

1990 • 180 citations

The role of platelets in the development and complications of atherosclerosis.

1986 • 178 citations

Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition.

1990 • 178 citations

Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid.

1989 • 173 citations

Platelet antiheparin activity

1975 • 146 citations

PLATELET-DERIVED GROWTH FACTOR

1987 • 136 citations

Effects of sulfinpyrazone on platelet prostaglandin synthesis and platelet release of serotonin.

1977 • 130 citations

Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders

1979 • 114 citations

Assembly of the prothrombinase complex in the absence of prothrombin.

1981 • 104 citations

Enhancement of mononuclear procoagulant activity by platelet 12-hydroxyeicosatetraenoic acid.

1986 • 97 citations

Actions of nitric oxide on the release of prostacyclin from bovine endothelial cells in culture

1988 • 96 citations

Role of triglycerides in endothelial cell arachidonic acid metabolism.

1983 • 92 citations

Enhanced platelet accumulation onto injured carotid arteries in rabbits after aspirin treatment.

1981 • 87 citations

POPULATION YEAR

1974 • 84 citations

Endothelial Cells Produce a Lipoxygenase Derived Chemo-Repellent which Influences Platelet/Endothelial Cell Interactions – Effect of Aspirin and Salicylate

1985 • 79 citations

On the Mechanism of Platelet Function Inhibition by Acetylsalicylic Acid,

1970 • 74 citations

Oral dipyridamole increases plasma adenosine levels in human beings

1989 • 73 citations

Platelets, Thrombosis and Atherosclerosis

1978 • 68 citations

Factor XI antigen and activity in human platelets

1982 • 67 citations

Human factor VIII procoagulant activity and phospholipid interaction

1981 • 67 citations

The subendothelium and thrombogenesis.

1972 • 66 citations

Human Platelets and Factor XI

1979 • 65 citations

Interleukin-1 increases tumor cell adhesion to endothelial cells through an RGD dependent mechanism: in vitro and in vivo studies

1990 • 61 citations

The role of arachidonate lipoxygenase and fatty acids during irreversible blood platelet aggregation in vitro

1981 • 60 citations

Quantitative Studies on the Release of Platelet Fibrinogen by Thrombin

1972 • 56 citations

Heparin as an adjunctive treatment after thrombolytic therapy for acute myocardial infarction

1991 • 55 citations

Vascular responses to endothelin-1 in atherosclerotic primates.

1990 • 51 citations

Endothelial cell membrane vesicles in the study of organ preference of metastasis.

1991 • 50 citations

The induced lipoxygenase in atherosclerotic aorta converts linoleic acid to the platelet chemorepellant factor 13-hode

1989 • 46 citations

Role of lipoxygenase metabolism in platelet function: Effect of aspirin and salicylate

1986 • 46 citations

Distribution of lipid microspheres incorporating prostaglandin E1 to vascular lesions

1990 • 45 citations

Lipo-prostaglandin preparations

1991 • 40 citations

Cyclic AMP regulation of endothelial cell triacylglycerol turnover, 13-hydroxyoctadecadienoic acid (13-HODE) synthesis and endothelial cell thrombogenecity

1990 • 39 citations

Endothelium and underlying membrane reactivity with platelets, leukocytes and tumor cells: Regulation by the lipoxygenase-derived fatty acid metabolites, 13-HODE and HETES

1988 • 37 citations

Relationship between vessel wall 13-HODE synthesis and vessel wall thrombogenecity following injury: Influence of salicylate and dipyridamole treatment

1990 • 34 citations

The Basement Membrane Underlying the Vascular Endothelium Is Not Thrombogenic: In Vivo and In Vitro Studies with Rabbit and Human Tissue

1987 • 32 citations

Selective effects of dietary fats on vascular 13-hode synthesis and platelet/vessel wall interactions

1990 • 28 citations

Albumin redirects platelet eicosanoid metabolism toward 12(S)-hydroxyeicosatetraenoic acid.

1989 • 25 citations

Inhibition of adenosine 3′,5′-cyclic monophosphate phosphodiesterase

1970 • 24 citations

Regulation of tumor cell adhesion by intracellular 13-HODE: 15-HETE ratio.

1990 • 17 citations

Linoleic acid and coronary heart disease.

1989 • 15 citations

Role of new antiplatelet agents as adjunctive therapies in thrombolysis

1991 • 14 citations

Differential localization of von Willebrand factor, fibronectin and 13-HODE in human endothelial cell cultures

1990 • 14 citations

Relative effects of flurbiprofen on platelet 12-hydroxy-eicosatetraenoic acid and thromboxane A2 production: Influence on collagen-induced platelet aggregation and adhesion

1989 • 14 citations

Role of 12-lipoxygenase products of arachidonic acid on platelet aggregation.

1987 • 13 citations

Role of new anticoagulants as adjunctive therapy during thrombolysis

1991 • 13 citations

Lipoxygenase products: Leukotrienes C4, D4, A4's breakdown products and 12-HPETE influence platelet aggregation in vivo

1985 • 11 citations

Inhibition of thrombus formation in vivo by novel antiplatelet agent.

1990 • 11 citations

Effect of dipyridamole and aspirin on vein graft patency after coronary bypass operations

1990 • 11 citations

13-HODE synthesis in internal mammary arteries and saphenous veins: implications in cardiovascular surgery.

1991 • 8 citations

Primary thrombocythaemia in childhood: Symptomatic episodes and their relationship thromboxane A2, 6-keto-PGE1 and 12-hydroxy-eicosatetraenoic acid production: A case report

1987 • 7 citations

Endothelial cell 13-HODE synthesis and tumor cell endothelial cell adhesion.

1991 • 7 citations

Heparin and Secondary Prevention of Acute Myocardial Infarction

1990 • 3 citations