Osteoblasts: Differentiation and Function

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Bone: Formation by Autoinduction

1965 • 5,498 citations

Novel Regulators of Bone Formation: Molecular Clones and Activities

1988 • 3,919 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix

1990 • 1,546 citations

Recombinant human bone morphogenetic protein induces bone formation.

1990 • 1,538 citations

Nuclear receptor that identifies a novel retinoic acid response pathway

1990 • 1,529 citations

Negative regulation of transforming growth factor-β by the proteoglycan decorin

1990 • 1,490 citations

Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors

1986 • 1,433 citations

Some recent advances in the chemistry and biology of transforming growth factor-beta.

1987 • 1,308 citations

Evidence of Estrogen Receptors in Normal Human Osteoblast-Like Cells

1988 • 1,246 citations

Osteonectin, a bone-specific protein linking mineral to collagen

1981 • 1,131 citations

Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence.

1986 • 1,078 citations

Bone and Mineral Research

1990 • 1,070 citations

An interleukin 1 like factor stimulates bone resorption in vitro

1983 • 1,017 citations

Identification and spatial distribution of retinoids in the developing chick limb bud

1987 • 964 citations

OSTEOBLASTIC CELLS ARE INVOLVED IN OSTEOCLAST FORMATION

1988 • 943 citations

Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose.

1986 • 870 citations

Mineralized bone nodules formedin vitro from enzymatically released rat calvaria cell populations

1986 • 855 citations

Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.

1990 • 837 citations

Estrogen Binding, Receptor mRNA, and Biologic Response in Osteoblast-Like Osteosarcoma Cells

1988 • 836 citations

Osteopontin--a possible anchor of osteoclasts to bone.

1990 • 816 citations

Biochemical Sequences in the Transformation of Normal Fibroblasts in Adolescent Rats

1972 • 815 citations

Cloning of murine α and β retinoic acid receptors and a novel receptor γ predominantly expressed in skin

1989 • 804 citations

Precursor Cells of Mechanocytes

1976 • 741 citations

Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro.

1991 • 735 citations

Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur.

1990 • 734 citations

A third human retinoic acid receptor, hRAR-gamma.

1989 • 686 citations

Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasone.

1988 • 656 citations

I. The Croonian Lecture

1810 • 634 citations

Purification and characterization of other distinct bone-inducing factors.

1988 • 621 citations

Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone.

1987 • 619 citations

Transport and Storage of Vitamin A

1990 • 618 citations

In VivoStimulation of Bone Formation by Transforming Growth Factor-β

1989 • 592 citations

Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro.

1987 • 561 citations

Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures.

1989 • 541 citations

Tumor necrosis factors alpha and beta induce osteoblastic cells to stimulate osteoclastic bone resorption.

1987 • 539 citations

1,25-Dihydroxyvitamin D3 increases synthesis of the vitamin K-dependent bone protein by osteosarcoma cells.

1980 • 503 citations

The Bone Marrow-Derived Stromal Cell Lines MC3T3-G2/PA6 and ST2 Support Osteoclast-Like Cell Differentiation in Cocultures with Mouse Spleen Cells

1989 • 501 citations

Production of osteocalcin by human bone cells in vitro. Effects of 1,25(OH)2D3, 24,25(OH)2D3, parathyroid hormone, and glucocorticoids

1984 • 500 citations

Parathyroid Hormone-Responsive Clonal Cell Lines from Rat Osteosarcoma*

1980 • 483 citations

Differential expression of genes encoding α, β and γ retinoic acid receptors and CRABP in the developing limbs of the mouse

1989 • 482 citations

Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization.

1986 • 456 citations

Morphological evidence of gap junctions between bone cells

1981 • 454 citations

Book Review: Treatise on Collagen

1969 • 442 citations

Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts.

1986 • 392 citations

Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activation

1977 • 389 citations

Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria.

1985 • 382 citations

Mineral and collagen-binding proteins of fetal calf bone.

1981 • 379 citations

Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: A possible role of interleukin-6 in osteoclastogenesis

1989 • 376 citations

SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix.

1989 • 375 citations

Estradiol Effects on Proliferation, Messenger Ribonucleic Acid for Collagen and Insulin-like Growth Factor-I, and Parathyroid Hormone-Stimulated Adenylate Cyclase Activity in Osteoblastic Cells from Calvariae and Long Bones

1989 • 369 citations

Differentiation-Linked Leukemogenesis in Lymphocytes

1986 • 359 citations

Pleiotropic Effects of Vitamin D on Osteoblast Gene Expression Are Related to the Proliferative and Differentiated State of the Bone Cell Phenotype: Dependency upon Basal Levels of Gene Expression, Duration of Exposure, and Bone Matrix Competency in Normal Rat Osteoblast Cultures*

1991 • 352 citations

Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis

1990 • 351 citations

Tissue specificity and developmental expression of rat osteopontin

1987 • 317 citations

Inhibition of hydroxyapatite-crystal growth by bone-specific and other calcium-binding proteins

1986 • 314 citations

Morphological and biochemical characterization of four clonal osteogenic sarcoma cell lines of rat origin.

1983 • 310 citations

The effect of 1,25(OH)2D3 on alkaline phosphatase in osteoblastic osteosarcoma cells.

1982 • 300 citations

The Biochemistry of Bone

1989 • 297 citations

Polarizing activity and retinoid synthesis in the floor plate of the neural tube

1990 • 292 citations

In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization.

1987 • 292 citations

Parathyroid hormone-activated calcium channels in an osteoblast-like clonal osteosarcoma cell line. cAMP-dependent and cAMP-independent calcium channels.

1987 • 283 citations

Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor.

1989 • 280 citations

The pathobiology of the osteoclast.

1985 • 280 citations

Functional Properties of Hormonally Responsive Cultured Normal and Malignant Rat Osteoblastic Cells*

1981 • 278 citations

Isolated osteoclasts resorb the organic and inorganic components of bone.

1986 • 276 citations

Epidermal growth factor stimulates prostaglandin production and bone resorption in cultured mouse calvaria

1978 • 271 citations

Osteocytic osteolysis

1969 • 265 citations

Excessive mineralization with growth plate closure in rats on chronic warfarin treatment.

1982 • 261 citations

Parathyroid hormone stimulates bone formation and resorption in organ culture: evidence for a coupling mechanism.

1981 • 260 citations

TGF-beta: problems and prospects.

1990 • 260 citations

Molecular endocrinology

1978 • 258 citations

Growth hormone dependent stimulation of osteoblast-like cells in serum-free cultures via local synthesis of insulin-like growth factor I

1988 • 253 citations

Identification of a bone sialoprotein receptor in osteosarcoma cells.

1988 • 248 citations

Role of prostaglandins in interleukin-1-induced bone resorption in mice in vitro

1991 • 239 citations

In vivo effects of human recombinant transforming growth factor β on bone turnover in normal mice

1990 • 235 citations

Isolation of bone cell clones with differences in growth, hormone responses, and extracellular matrix production.

1982 • 234 citations

Identification of Committed Mononuclear Precursors for Osteoclast-Like Cells Formed in Long Term Human Marrow Cultures*

1990 • 232 citations

Bone cells predispose bone surfaces to resorption by exposure of mineral to osteoclastic contact

1985 • 229 citations

Stromal Mechanisms of Bone Marrow: Cloning in Vitro and Retransplantation in Vivo

1980 • 226 citations

Stimulation of the expression of osteogenic and chondrogenic phenotypes in vitro by osteogenin.

1989 • 224 citations

Effects of Transforming Growth Factor-β on Osteoblastic Osteosarcoma Cells*

1987 • 215 citations

Stimulation of bone formation by prostaglandin E2

1984 • 212 citations

Multiple cell type-specific proteins differentially regulate target sequence recognition by the α retinoic acid receptor

1990 • 211 citations

Parathyroid hormone receptor in intact embryonic chicken bone: characterization and cellular localization.

1982 • 209 citations

Transcriptional regulation of osteopontin production in rat osteosarcoma cells by type beta transforming growth factor.

1988 • 206 citations

Mammalian collagenase predisposes bone surfaces to osteoclastic resorption

1985 • 203 citations

Interactions of thrombospondin with extracellular matrix proteins: selective binding to type V collagen.

1984 • 202 citations

Generation of osteoclasts from isolated hematopoietic progenitor cells

1989 • 201 citations

The Cellular Basis of Bone Resorption

1980 • 201 citations

Type β transforming growth factor (TGFβ) regulation of alkaline phosphatase expression and other phenotype‐related mRNAs in osteoblastic rat osteosarcoma cells

1987 • 196 citations

1,25-Dihydroxyvitamin D3 stimulates the alkaline phosphatase activity of osteoblast-like cells.

1981 • 195 citations

Mouse osteoblasts synthesize collagenase in response to bone resorbing agents

1984 • 192 citations

1,25-Dihydroxyvitamin D3 Regulates the Biosynthesis of Osteopontin, a Bone-Derived Cell Attachment Protein, in Clonal Osteoblast-Like Osteosarcoma Cells

1987 • 187 citations

Hormonal Regulation of the Production of Collagenase and a Collagenase Inhibitor Activity by Rat Osteogenic Sarcoma Cells*

1987 • 186 citations

lDirect Stimulation of Bone Resorption by Epidermal Growth Factor*

1980 • 182 citations

Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro.

1986 • 180 citations

Gene expression during osteogenic differentiation in mandibular condyles in vitro.

1990 • 177 citations

Chemotactic activity of theγ-carboxyglutamic acid containing protein in bone

1983 • 174 citations

Bone-Inducing Activity of Mature BMP-2b Produced from a Hybrid BMP-2a/2b Precursor

1991 • 172 citations

Induction of Calcitonin Receptors by lα, 25- Dihydroxyvitamin D₃in Osteoclast-Like Multinucleated Cells Formed from Mouse Bone Marrow Cells*

1988 • 169 citations

Receptors for 1,25(OH)₂‐vitamin D₃ enriched in cloned osteoblast‐like rat osteogenic sarcoma cells

1980 • 167 citations

Pig interleukin 1 (Catabolin) is a potent stimulator of bone resorptionin vitro

1985 • 166 citations

Functional mapping of SPARC: peptides from two distinct Ca+(+)-binding sites modulate cell shape.

1990 • 164 citations

Leukemia Inhibitory Factor: A Novel Bone-Active Cytokine*

1990 • 155 citations

Accumulation, localization, and compartmentation of transforming growth factor beta during endochondral bone development.

1988 • 154 citations

Regulation of Plasminogen Activator Production by Bone-Resorbing Hormones in Normal and Malignant Osteoblasts*

1985 • 151 citations

Parathyroid hormone acutely elevates intracellular calcium in osteoblastlike cells

1987 • 148 citations

Parathyroid hormone-responsive adenylate cyclase in induced transplantable osteogenic rat sarcoma

1976 • 145 citations

Effect of substrate composition on bone resorption by rabbit osteoclasts

1984 • 142 citations

1,25-Dihydroxyvitamin D3 stimulates the synthesis of matrix gamma-carboxyglutamic acid protein by osteosarcoma cells. Mutually exclusive expression of vitamin K-dependent bone proteins by clonal osteoblastic cell lines.

1988 • 140 citations

Growth Hormone (GH) Receptors in Clonal Osteoblast Like Cells Mediate a Mitogenic Response to GH*

1991 • 139 citations

Immunohistochemical Detection of Parathyroid Hormone-Related Protein in Human Fetal Epithelia*

1991 • 139 citations

The bone lining cell: A distinct phenotype?

1987 • 138 citations

The Cellular Basis of Bone Turnover and Bone Loss

1977 • 135 citations

Osteoblasts display receptors for and responses to leukemia‐inhibitory factor

1990 • 134 citations

Effects of Tumor Necrosis Factor on Bone Formationin Vitro*

1987 • 134 citations

Transcriptional regulation of osteopontin production in rat osteoblast-like cells by parathyroid hormone.

1989 • 130 citations

Thrombospondin is an osteoblast-derived component of mineralized extracellular matrix.

1989 • 130 citations

Vasoactive Intestinal Peptide Stimulates Bone Resorption via a Cyclic Adenosine 3′,5′-Monophosphate-Dependent Mechanism*

1983 • 127 citations

Synthesis of collagenase and collagenase inhibitors by osteoblast-like cells in culture

1984 • 125 citations

Rat Calvarial Cell Lines Immortalized with SV-40 Large T Antigen: Constitutive and Retinoic Acid- Inducible Expression of Osteoblastic Features

1989 • 121 citations

Selective hormonal activation of cyclic AMP-dependent protein kinase isoenzymes in normal and malignant osteoblasts.

1982 • 119 citations

Transcriptional Regulation of Osteocalcin Production by Transforming Growth Factor-β in Rat Osteoblast-Like Cells

1989 • 114 citations

Parathyroid Hormone Bindingin Vivoto Renal, Hepatic, and Skeletal Tissues of the Rat Using a Radioautographic Approach*

1986 • 110 citations

The Onset and Progression of Osteoblast Differentiation is Functionally Related to Cellular Proliferation

1989 • 106 citations

Regulation of bone sialoprotein mRNA by steroid hormones.

1989 • 105 citations

Lack of a direct effect of estrogen on proliferation and differentiation of normal human osteoblast-like cells

1991 • 105 citations

Cyclic AMP-mediated stabilization of osteocalcin mRNA in rat osteoblast-like cells treated with parathyroid hormone.

1988 • 102 citations

Synergism between parathyroid hormone and interleukin 1 in stimulating bone resorption in organ culture

1987 • 101 citations

Biology of Collagen

1980 • 98 citations

Parathyroid hormone and prostaglandin E2 stimulate both inositol phosphates and cyclic AMP accumulation in mouse osteoblast cultures

1988 • 98 citations

Stimulation of plasminogen activator in osteoblast-like cells by bone-resorbing hormones

1984 • 95 citations

Complex formation of human thrombospondin with osteonectin

1988 • 95 citations

Regulation of alkaline phosphatase expression in a neonatal rat clonal calvarial cell strain by retinoic acid

1988 • 91 citations

Distribution of fibroblastic colony-forming cells in rabbit bone marrow and assay of their osteogenic potential by anin vivo diffusion chamber method

1984 • 89 citations

1,25-Dihydroxyvitamin D₃Inhibits Transcription of Type I Collagen Genes in the Rat Osteosarcoma Cell Line ROS 17/2.8*

1989 • 88 citations

Cloning of an osteoblastic cell line involved in the formation of osteoclast‐like cells

1990 • 88 citations

Inhibitory effects of parathyroid hormone on growth of osteogenic sarcoma cells

1985 • 86 citations

Experimental study of changes in osteoblastic shape induced by calcitonin and parathyroid extract in an organ culture system

1976 • 85 citations

Direct effect of parathyroid hormone on the proliferation of osteoblast-like cells; A possible involvement of cyclic AMP

1985 • 83 citations

Differential Regulation of Plasminogen Activator and Plasminogen Activator Inhibitor by Osteotropic Factors in Primary Cultures of Mature Osteoblasts and Osteoblast Precursors*

1990 • 81 citations

Epidermal growth factor receptors in clonal lines of a rat osteogenic sarcoma and in osteoblast-rich rat bone cells

1983 • 80 citations

Retinoic acid increases zif268 early gene expression in rat preosteoblastic cells.

1991 • 79 citations

Effects of calcitonin gene-related peptide on cyclic AMP formation in chicken, rat, and mouse bone cells

1989 • 79 citations

Structural requirements for the action of parathyroid hormone-related protein (PTHrP) on bone resorption by isolated osteoclasts

1991 • 79 citations

Retinoic acid modulation of mrna levels in malignant, nontransformed, and immortalized osteoblasts

1991 • 78 citations

Bone Cell Physiology

1989 • 76 citations

Parathyroid hormone binding to cultured avian osteoclasts

1991 • 75 citations

Stimulation of DNA synthesis by epidermal growth factor in osteoblast-like cells

1983 • 70 citations

Parathyroid Hormone and Parathyroid Hormone-Related Peptide Stimulate Insulin-Like Growth Factor-Binding Protein Secretion by Rat Osteoblast-Like Cells through a Adenosine 3′,5′-Monophosphate-Dependent Mechanism*

1991 • 70 citations

Cyclo-oxygenase products of arachidonic acid metabolism in rat osteoblasts in culture

1983 • 68 citations

Opposing Influences of Glucocorticoid and Retinoic Acid on Transcriptional Control in Preosteoblasts

1989 • 65 citations

Second Messenger Signaling in the Regulation of Collagenase Production by Osteogenic Sarcoma Cells*

1989 • 64 citations

Transforming growth factor beta inhibits plasminogen activator (PA) activity and stimulates production of urokinase‐type PA, PA inhibitor‐1 mRNA, and protein in rat osteoblast‐like cells

1991 • 64 citations

Immunohistochemical Demonstration of Parathyroid Hormone Binding to Specific Cell Types in Fixed Rat Bone Tissue

1983 • 63 citations

1,25-Dihydroxyvitamin D receptors in an established bone cell line. Correlation with biochemical responses.

1982 • 62 citations

Assessment of anin vivo diffusion chamber method as a quantitative assay for osteogenesis

1984 • 62 citations

Sensitivity of cultured human osteosarcoma and chondrosarcoma cells to retinoic acid.

1982 • 61 citations

Epidermal growth factor and phorbol ester actions on human osteosarcoma cells. Characterization of response and nonresponsive cell lines.

1982 • 60 citations

Type I collagen degradation by mouse calvarial osteoblasts stimulated with 1,25-dihydroxyvitamin D-3: evidence for a plasminogen-plasmin-metalloproteinase activation cascade

1989 • 59 citations

Existence of parathyroid hormone binding sites on murine hemopoietic blast cells

1989 • 58 citations

Leukemia inhibitory factor (LIF) inhibits basal bone resorption in fetal rat long bone cultures

1990 • 58 citations

<b>IMMUNOCYTOCHEMICAL LOCALIZATION OF COLLAGENASE IN ISOLATED MOUSE BONE </b><b>CELLS </b>

1984 • 58 citations

Effects of Parathormone and Calcitonin on Citrate and Hyaluronate Metabolism in Cultured Bone

1976 • 57 citations

La3+, Mn2+, and Ni2+ effects on Ca2+ pump and on Na+-Ca2+ exchange in bullfrog ventricle

1987 • 56 citations

Osteonectin inhibitingde novo formation of apatite in the presence of collagen

1989 • 56 citations

Effects of Retinoic Acid on Alkaline Phosphatase Messenger Ribonucleic Acid, Catecholamine Receptors, and G Proteins in ROS 17/2.8 Cells

1988 • 55 citations

Collagenase and bone resorption: Isolation of collagenase from culture medium containing serum after stimulation of bone resorption by addition of parathyroid hormone extract

1975 • 55 citations

Effect of retinoids on the growth, ultrastructure, and cytoskeletal structures of malignant rat osteoblasts.

1985 • 54 citations

Croonian Lecture - Nutrition in relation to bone growth and the nervous system

1944 • 54 citations

Effects of exogenous prostanoids on the proliferation of osteoblast-like cells in vitro

1985 • 52 citations

Elevated bone collagenolytic activity and hyperplasia of parafollicular light cells of the thyroid gland in parathormone-treated grey-lethal mice

1966 • 49 citations

Cyclic AMP-dependent and -independent effects on tissue-type plasminogen activator activity in osteogenic sarcoma cells; evidence from phosphodiesterase inhibition and parathyroid hormone antagonists

1986 • 44 citations

1,25-Dihydroxyvitamin D3 effects on collagen and DNA synthesis in periosteum and periosteum-free calvaria

1985 • 37 citations

Structure and interactions of proteoglycans in the extracellular matrix produced by cultured human fibroblasts

1985 • 37 citations

<b>ISOLATION AND CHARACTERIZATION OF COLLAGENASE SYNTHESIZED BY MOUSE BONE CELLS IN </b><b>CULTURE </b>

1984 • 35 citations

Early scanning electron microscopic studies of hard tissue resorption: their relation to current concepts reviewed.

1987 • 35 citations

Parathyroid Hormone Stimulation of Collagenase Secretion by Isolated Bone Cells*

1979 • 34 citations

Mouse Osteoblastic Cells (MC3T3-E1) at Different Stages of Differentiation Have Opposite Effects on Osteoclastic Cell Formation

1991 • 32 citations

Characterization of the receptor for insulin‐like growth factor II in bone cells

1989 • 30 citations

Release of parathyroid hormonelike peptides by fetal rat long bones in culture

1990 • 29 citations

The further purification and characterization of mouse bone collagenase

1972 • 29 citations

Osteoclasts Derive from Hematopoietic Stem Cells According to Marker, Giant Lysosomes of Beige Mice

1981 • 28 citations

Insulinlike growth factor 1 regulates mRNA levels of osteonectin and pro-α1(I)-collagen in clonal preosteoblastic calvarial cells

1990 • 26 citations

Retinoic acid and tumour necrosis factor-α act in concert to control the level of alkaline phosphatase mRNA

1989 • 25 citations

Effect of retinoic acid on cellular content and human parathyroid hormone activation of cyclic adenosine 3':5'-monophosphate-dependent protein kinase isoenzymes in clonal rat osteogenic sarcoma cells.

1985 • 18 citations

9 Osteogenesis imperfecta

1988 • 17 citations

Bone cell physiology and in vitro techniques in its investigation

1990 • 4 citations

Deleted Work

1955 • 0 citations